Entry
Name
aklanonic acid methyl ester cyclase;
dauD (gene name);
aknH (gene name);
dnrD (gene name);
methyl aklanonate cyclase;
methyl aklanonate-aklaviketone isomerase (cyclizing);
aklaviketone lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
aklaviketone lyase (ring-opening)
Reaction(IUBMB)
aklaviketone = methyl aklanonate [RN:
R06681 ]
Reaction(KEGG)
Substrate
Product
methyl aklanonate [CPD:
C12422 ]
Comment
The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin.
History
EC 5.5.1.23 created 2013, modified 2014
Pathway
ec01057 Biosynthesis of type II polyketide products
ec01110 Biosynthesis of secondary metabolites
Orthology
K15943 nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase
Genes
SPRI : SPRI_0207 SPRI_7146
SCHA : CP983_03560 CP983_03585
» show all
Taxonomy
Reference
Authors
Dickens ML, Ye J, Strohl WR
Title
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5.
Journal
Sequence
Reference
Authors
Kendrew SG, Katayama K, Deutsch E, Madduri K, Hutchinson CR
Title
DnrD cyclase involved in the biosynthesis of doxorubicin: purification and characterization of the recombinant enzyme.
Journal
Sequence
Reference
Authors
Kallio P, Sultana A, Niemi J, Mantsala P, Schneider G
Title
Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.23
ExPASy - ENZYME nomenclature database: 5.5.1.23