KEGG ENZYME: 5.5.1.24

ENZYME: 5.5.1.24

Entry

EC 5.5.1.24                 Enzyme

Name

tocopherol cyclase;
VTE1 (gene name);
SXD1 (gene name);
delta/gamma-tocopherol lyase (decyclizing)

Class

Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)

Sysname

delta/gamma-tocopherol lyase (ring-opening)

Reaction(IUBMB)

(1) delta-tocopherol = 2-methyl-6-phytylbenzene-1,4-diol  [RN:R07503];
(2) gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol  [RN:R07502];
(3) delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol  [RN:R10623];
(4) gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [RN:R10624]

Reaction(KEGG)

R07502 R07503 R10623 R10624

Substrate

delta-tocopherol [CPD:C14151];
gamma-tocopherol [CPD:C02483];
delta-tocotrienol [CPD:C14156];
gamma-tocotrienol [CPD:C14155]

Product

2-methyl-6-phytylbenzene-1,4-diol [CPD:C15882];
2,3-dimethyl-6-phytylbenzene-1,4-diol [CPD:C15883];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD:C20737];
6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [CPD:C20738]

Comment

The enzyme has been described from plants and cyanobacteria. It has similar activity with all four listed benzoquinol substrates. Involved in the biosynthesis of vitamin E (tocopherols and tocotrienols).

History

EC 5.5.1.24 created 2013

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K09834

tocopherol cyclase

Genes

ATH:	AT4G32770(VTE1)

ALY:

9305317

CRB:

17877607

CSAT:

104716894 104720514 104721549 104729992

EUS:	EUTSA_v10025006mg

BRP:

103862197

BNA:	106411207 106423394

BOE:

106301700

RSZ:	108851396 130511472

THJ:

104803808

CPAP:

110822117

CIT:

102615028

CIC:	CICLE_v10008169mg

PVY:	116114612 116114613

MINC:

123194912 123194913

TCC:

18587955

GRA:	105762967 105769163

GHI:	107900519 107906956 107953842 121229241

GAB:	108459692 108472002

HSYR:

120114804 120136179 120166651

DZI:

111302940

EGR:

104437768

GMX:	100791679 100809310

GSJ:	114409109 114415137

PVU:	PHAVU_009G108200g

VRA:

106762339

VAR:

108318687

VUN:

114164033

VUM:

124822643

CCAJ:

109801639

APRC:

113864761

MTR:

25490120

TPRA:

123893713

CAM:

101502250

PSAT:

127084642

VVO:	131660061 131660075

ADU:

107470774

AIP:

107623139

AHF:	112716148 112784216

LANG:

109339295

PCIN:

129302420 129302421

QSA:	O6P43_019281

FVE:

101304641

RCN:

112173193

PPER:

18791199

PMUM:

103320200

PAVI:

110761173

PDUL:

117616313

MDM:	103428784 103456033

MSYL:

126604527 126633257

PXB:	103937837 103957110 103957461

MNT:	21390651 21390653

CSAV:

115699277

CSV:

101206720

CMO:

103488188

BHJ:

120075560

MCHA:

111004926

CMAX:

111496186

CMOS:

111454510

CPEP:

111799319

RCU:

8271188

JCU:

105638244

HBR:

110669879

MESC:

110603804

POP:	18100669 18107478

PEU:

105127155

PALZ:

118032790 118051181 118053486

JRE:	109007374 109009500

CILL:

122317563 122318800

CAVE:

132189356 132190937

QSU:

112016280

QLO:

115971144

TWL:

119997389

VVI:

100268095

VRI:

117912811

SLY:

101263925

SPEN:

107026784

SOT:	102577462(SXD1)

SSTN:

125842392

SDUL:

129889444

CANN:

107839135

LBB:

132635633

NTA:	107798727 107806714(TC)

NSY:

104221249

NTO:

104098970

NAU:

109234037

INI:

109178717

ITR:

116005566

SIND:

105164753

OEU:

111385234

EGT:

105977167

SSPL:

121785062

SMIL:

131015255

SHIS:

125217021

APAN:

127265681

HAN:

110873807

ECAD:

122578737

LSV:

111907085

DCR:

108225390

CSIN:

114295292

RVL:

131316944

AEW:

130757223

BVG:

104885180

SOE:

110775274

CQI:

110705597

ATRI:

130802855 130802856

MOF:

131151929

NNU:

104595147

MING:

122076820

TSS:

122654166

PSOM:

113348252 113349107

OSA:

4329007

DOSA:

Os02t0276500-01(Os02g0276500)

OBR:

102712058

OGL:

127761124

BDI:

100846924

ATS:

109734383

TDC:	119276114 119340110

TAES:

123052679 123128989 123181719

TUA:

125514085

LPER:

127320950

LRD:	124692135 124692146

SBI:

8060379

ZMA:

541877

SITA:

101764913

SVS:

117851187

PVIR:

120655379 120697746

PHAI:

112886331

PDA:

103702550

EGU:

105040851

MUS:

103995049

ZOF:	122052195 122052197 122056681 122056683

DCT:

110106522

PEQ:

110025563

AOF:

109821288

MSIN:

131223037

NCOL:

116254650

ATR:

18426679

SMO:	SELMODRAFT_143592 SELMODRAFT_172178

PPP:	112273462 112284896

CRE:	CHLRE_01g013801v5

VCN:	VOLCADRAFT_42287

MNG:	MNEG_11580

CSL:	COCSUDRAFT_12504

CVR:	CHLNCDRAFT_19624

APRO:

F751_1103

OLU:	OSTLU_39591

OTA:	OT_ostta01g01855

BPG:	Bathy01g01730

MIS:	MICPUN_68115

MPP:	MICPUCDRAFT_33085(JGI:MicpuC2_33085)

CME:	CYME_CML326C

PNO:	SNOG_07016

BOR:	COCMIDRAFT_92776

AALT:

CC77DRAFT_1019104

PCO:	PHACADRAFT_254191

PTI:	PHATRDRAFT_bd1025(VTE1)

FCY:	FRACYDRAFT_242143(VTE1)

TPS:	THAPSDRAFT_263019

AAF:	AURANDRAFT_65060

EHX:	EMIHUDRAFT_237937 EMIHUDRAFT_54133 EMIHUDRAFT_98577

EHR:

EHR_02320

ECAS:

ECBG_00190

EMU:

EMQU_0164

EGA:	AL523_09215

EIE:	ENLAB_26220

CRN:	CAR_c02300

CAW:	Q783_00780

CARC:

NY10_1012

CVD:	LHA31_05915

JEP:	BW721_01460

JDA:	BW727_101359

JEH:	EJN90_00875

JPO:	G7058_09500

DINC:

QNK01_00235

CCB:	Clocel_0502

CLB:	Clo1100_2348

CARG:

RSJ17_06920

CGAS:

J1C67_16955

CMAH:

C1I91_09090

CRW:	CROST_043670

CFB:	CLFE_004350

CAUN:

CLAUR_031430

CINT:

HZF06_08550

CCE:

Ccel_1994

RPAY:

P0092_13525

CCEL:

CCDG5_0731

LASA:

L9O85_09640

CFEM:

HCR03_10095

DED:	DHBDCA_p2010

DEC:	DCF50_p2022

AWO:	Awo_c01810

AWI:	CHL1_000153

ALKA:

J0B03_11880

ACAE:

HYG86_14240

BPB:

bpr_I1006

BHU:

bhn_I1975

CSH:	Closa_1049

ANR:	Ana3638_07040

ACHT:

bsdcttw_10320

CLE:	Clole_2217

CEW:	EKH84_13735

VPY:	HZI73_14995 HZI73_19765

AMT:

Amet_3459

AOE:

Clos_0174

TEM:	JW646_11335

TGC:	L0P85_16420

TMY:	TEMA_25130

TUR:	AT726_05395

TSG:	HLK68_04145

TBB:	J0J69_08315

ACL:

ACL_1398

AOC:	Aocu_02520

ABRA:

BN85314670

MANR:

MPAN_016600

TBK:	HF295_07915

TBM:	BK010_09890

TBZ:	BK011_09920

MMAL:

CKJ54_17760

MUL:

MUL_2705

MMI:

MMAR_3430

MMAE:

MMARE11_33380

MLI:	MULP_03697

MPSE:

MPSD_35110

MSHO:

MSHO_48460

MKN:	MKAN_03880

MPAG:

C0J29_08880

MBAI:

MB901379_03072

MSEO:

MSEO_20150

MOT:	LTS72_07270

MGI:

Mflv_4428

MSP:	Mspyr1_38280

CEF:

CE1100

CHN:	A605_05105

CHM:	B842_04640

CTED:

CTEST_04575

RER:

RER_16120

REY:

O5Y_07695

REB:	XU06_07935

RHOD:

AOT96_18540

DIT:	C3V38_00415

DIZ:	CT688_10440

DPC:	A6048_10625

DLU:	A6035_10140

MHOS:

CXR34_15730

MPRT:

ET475_06200

AGY:	ATC03_02330

AMAV:

GCM10025877_03940

ARL:	AFL94_11610

ARY:	ATC04_06615

TFL:	RPIT_10805

TDF:	H9L22_03675

RAIN:

Rai3103_16110

PRV:	G7070_13760

BRT:	J4N02_07000

FSL:	EJO69_11060

SYN:

slr1737

SYZ:	MYO_112090

SYY:	SYNGTS_1199(slr1737)

SYT:	SYNGTI_1199(slr1737)

SYS:	SYNPCCN_1198(slr1737)

SYQ:	SYNPCCP_1198(slr1737)

SYJ:	D082_16890

SYO:	C7I86_06215

CYA:	CYA_0654 CYA_0896

CYB:

CYB_0605

SYNE:

Syn6312_3402

SYNP:

Syn7502_02454

DSL:	Dacsa_1404

WNA:	KA717_23275

CMP:	Cha6605_5219

CYN:	Cyan7425_2596

CEP:	Cri9333_2174

AMR:

AM1_2430

LEN:	LEP3755_10640

LET:	O77CONTIG1_04231

LBO:	LBWT_47570

KOV:	K9N68_14070

LSC:	KIK02_22075

LSK:	J5X98_13100

HHG:	XM38_007350

PSEU:

Pse7367_1064

THEU:

HPC62_20290

TOG:	HNI00_12125

TSIN:

OXH18_20070

GLP:	Glo7428_3471

CHON:

NIES4102_16140

GDU:	P0S91_01190

SYP:	SYNPCC7002_A0670

SYV:	AWQ23_03505

SYL:	AWQ21_04120

LEP:	Lepto7376_2265

SYNN:

NIES970_00320

MAR:

MAE_59750

MPK:

VL20_741

MIQ:	B5D77_23570

MVZ:	myaer102_31940

HAO:	PCC7418_3554

ENN:	FRE64_00920

CYT:

cce_3689

CWA:	CwatDRAFT_6621

CYP:	PCC8801_1078

CYH:	Cyan8802_1107

CYC:	PCC7424_0003

CYJ:	Cyan7822_0003

TER:

Tery_1802

ARP:	NIES39_E00630

PAGH:

NIES204_01690

PPSU:

NO713_04432(VTE1)

PRUN:

PCC7821_04230(VTE1)

OXY:	HCG48_06465

LFS:	HFV01_20990

OAC:	Oscil6304_3929

ONI:	Osc7112_5394

MPRO:

BJP34_30130

PHOR:

JWS08_03365

PYH:	NEA10_08895

MIC:	Mic7113_1871

GEI:	GEI7407_2531

GVI:

glr3089

GLJ:

GKIL_0805

GML:	ISF26_14305

ANA:

all0245

NPU:	Npun_R0149

NOS:	Nos7107_1763

NOP:	Nos7524_3438

NON:	NOS3756_32540

NFL:	COO91_05004

NOE:	CLI64_21410

NSH:

GXM_05592

NED:	HUN01_08115

NPZ:	ACX27_26200

AVA:

Ava_2735

NAZ:

Aazo_3505

ANB:	ANA_C10369

ACY:	Anacy_5164

AWA:	AA650_24360

ANN:	EH233_14325

CSG:	Cylst_5807

RSIN:

B6N60_00008

HBQ:	QI031_25465

CALO:

Cal7507_3269

CALT:

Cal6303_4731

CALH:

IJ00_12110

CALN:

NIES2098_38250

CALS:

NIES3974_24340

RIV:	Riv7116_0097

FIS:	FIS3754_00340

NSP:	BMF81_02295

NSPH:

BDGGKGIB_01888

DOU:	BMF77_01243

DFS:	HGD76_10995

DHT:	NG743_11410

CCUR:

IAR63_12000

CRK:	L3I90_01335

AFLO:

HEQ12_13190

STOQ:

K2F26_04000

AEE:	IM676_11690

RCS:	NIES932_02990

TOQ:	HCG51_00045

ALAX:

NIES50_17630

NCN:	BZZ01_27980

CTHE:

Chro_1644

PLP:	Ple7327_0186

SCS:	Sta7437_3667

STAN:

STA3757_38860

PBF:	CFX0092_A3137

PMET:

G4Y79_17120

SFC:	Spiaf_2472

SPER:

EW093_08460

SBU:	SpiBuddy_2579

SGP:	SpiGrapes_2372

SASS:

MUG09_13800

MICA:

P0L94_17070

DRC:	G0Q07_01490

ANF:

AQPE_1782

HHY:	Halhy_2751

TAF:

THA_709

MAEO:

JRV97_10160

MPG:	Theba_2038

MINF:

MESINF_1223

ASAC:

ATHSA_1559

METB:

AW729_02110

MRU:

mru_0432

MMIL:

sm9_0735

MEYE:

TL18_03560

MOL:

YLM1_0103

MEL:	Metbo_1072

MEME:

HYG87_02110

MBAK:

MSBR3_0408

MMA:

MM_0519

MMAZ:

MmTuc01_0540

MMJ:	MSMAS_0787

MMAC:

MSMAC_0766

MTHR:

MSTHT_0418

MTHE:

MSTHC_0303

MFZ:	AOB57_000120

LOKI:

Lokiarch_32970

LOB:	NEF87_000526

PSYT:

DSAG12_01668

» show all

Reference

1 [PMID:12213958]

Authors

Porfirova S, Bergmuller E, Tropf S, Lemke R, Dormann P.

Title

Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis.

Journal

Proc Natl Acad Sci U S A 99:12495-500 (2002)
DOI:10.1073/pnas.182330899

Sequence

[ath:AT4G32770]

Reference

2 [PMID:12913173]

Authors

Sattler SE, Cahoon EB, Coughlan SJ, DellaPenna D

Title

Characterization of tocopherol cyclases from higher plants and cyanobacteria. Evolutionary implications for tocopherol synthesis and function.

Journal

Plant Physiol 132:2184-95 (2003)
DOI:10.1104/pp.103.024257

Sequence

[ath:AT4G32770] [zma:541877] [syn:slr1737]

Other DBs

ExplorEnz - The Enzyme Database:

5.5.1.24

IUBMB Enzyme Nomenclature:

5.5.1.24

ExPASy - ENZYME nomenclature database:

5.5.1.24

BRENDA, the Enzyme Database:

5.5.1.24

DBGET integrated database retrieval system