| Entry |
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| Name |
nogalonic acid methyl ester cyclase;
methyl nogalonate cyclase;
SnoaL (gene name);
methyl nogalonate lyase (cyclizing)
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| Class |
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
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| Sysname |
nogalaviketone lyase (ring-opening)
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| Reaction(IUBMB) |
nogalaviketone = methyl nogalonate [RN: R09328]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
methyl nogalonate [CPD: C12415]
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| Comment |
The enzyme, characterized from the bacterium Streptomyces nogalater, is involved in the biosynthesis of the aromatic polyketide nogalamycin.
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| History |
EC 5.5.1.26 created 2015
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| Pathway |
| ec01057 | Biosynthesis of type II polyketide products |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K15943 | nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase |
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| Genes |
| SPRI: | SPRI_0207 SPRI_7146 |
| SCHA: | CP983_03560 CP983_03585 |
» show all
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| Reference |
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| Authors |
Sultana A, Kallio P, Jansson A, Wang JS, Niemi J, Mantsala P, Schneider G |
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| Title |
Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation. |
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| Journal |
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| Reference |
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| Authors |
Sultana A, Kallio P, Jansson A, Niemi J, Mantsala P, Schneider G |
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| Title |
Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.5.1.26 |
| ExPASy - ENZYME nomenclature database: | 5.5.1.26 |
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