Entry |
|
Name |
(-)-kolavenyl diphosphate synthase;
SdKPS;
TwTPS14;
TwTPS10/KPS;
SdCPS2;
clerodienyl diphosphate synthase;
CLPP
|
Class |
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
|
Sysname |
(-)-kolavenyl diphosphate lyase (ring-opening)
|
Reaction(IUBMB) |
geranylgeranyl diphosphate = (-)-kolavenyl diphosphate [RN: R11869]
|
Reaction(KEGG) |
|
Substrate |
geranylgeranyl diphosphate [CPD: C00353]
|
Product |
(-)-kolavenyl diphosphate [CPD: C21735]
|
Comment |
Isolated from the hallucinogenic plant Salvia divinorum (seer's sage) and the medicinal plant Tripterygium wilfordii (thunder god vine).
|
History |
EC 5.5.1.28 created 2017
|
Pathway |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K22948 | (-)-kolavenyl diphosphate synthase |
|
Genes |
SHIS: | 125188980 125217217 |
|
Reference |
|
Authors |
Hansen NL, Heskes AM, Hamberger B, Olsen CE, Hallstrom BM, Andersen-Ranberg J, Hamberger B |
Title |
The terpene synthase gene family in Tripterygium wilfordii harbors a labdane-type diterpene synthase among the monoterpene synthase TPS-b subfamily. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Chen X, Berim A, Dayan FE, Gang DR |
Title |
A (-)-kolavenyl diphosphate synthase catalyzes the first step of salvinorin A biosynthesis in Salvia divinorum. |
Journal |
|
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 5.5.1.28 |
ExPASy - ENZYME nomenclature database: | 5.5.1.28 |
|