KEGG   ENZYME: 5.5.1.31
Entry
EC 5.5.1.31                 Enzyme                                 
Name
hapalindole H synthase;
famC2 (gene name);
famC3 (gene name)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (hapalindole H-forming)
Reaction(IUBMB)
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H [RN:R12004]
Reaction(KEGG)
R12004
Substrate
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole [CPD:C21837]
Product
hapalindole H [CPD:C21838]
Comment
The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, forms the core structure of the hapalindole family of alkaloids. The enzyme is a heterodimeric complex.
History
EC 5.5.1.31 created 2018
Orthology
K22971  hapalindole H/12-epi-hapalindole U/12-epi-fischerindole U synthase
Reference
1  [PMID:28288107]
  Authors
Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH
  Title
Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.
  Journal
Nat Chem Biol 13:467-469 (2017)
DOI:10.1038/nchembio.2327
  Sequence
[ag:APB62244 APB62245]
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.31
IUBMB Enzyme Nomenclature: 5.5.1.31
ExPASy - ENZYME nomenclature database: 5.5.1.31
BRENDA, the Enzyme Database: 5.5.1.31

  All links  
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (4)   
All databases (8)   

Download RDF
DBGET integrated database retrieval system