KEGG   ENZYME: 5.5.1.32
Entry
EC 5.5.1.32                 Enzyme                                 
Name
12-epi-hapalindole U synthase;
famC1 (gene name);
HpiC1 (gene name)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (12-epi-hapalindole U-forming)
Reaction(IUBMB)
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-hapalindole U [RN:R12005]
Reaction(KEGG)
R12005
Substrate
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole [CPD:C21837]
Product
12-epi-hapalindole U [CPD:C21839]
Comment
The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, forms the core structure of the 12-epi-hapalindole family of alkaloids.
History
EC 5.5.1.32 created 2018
Orthology
K22971  hapalindole H/12-epi-hapalindole U/12-epi-fischerindole U synthase
Reference
1  [PMID:26629885]
  Authors
Li S, Lowell AN, Yu F, Raveh A, Newmister SA, Bair N, Schaub JM, Williams RM, Sherman DH
  Title
Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade.
  Journal
J Am Chem Soc 137:15366-9 (2015)
DOI:10.1021/jacs.5b10136
  Sequence
[ag:APB62243]
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.32
IUBMB Enzyme Nomenclature: 5.5.1.32
ExPASy - ENZYME nomenclature database: 5.5.1.32
BRENDA, the Enzyme Database: 5.5.1.32

  All links  
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (4)   
All databases (8)   

Download RDF
DBGET integrated database retrieval system