KEGG ENZYME: 5.5.1.9

ENZYME: 5.5.1.9

Entry

EC 5.5.1.9                  Enzyme

Name

cycloeucalenol cycloisomerase;
cycloeucalenol---obtusifoliol isomerase;
cycloeucalenol lyase (cyclopropane-decyclizing)

Class

Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)

Sysname

cycloeucalenol lyase (cyclopropane-ring opening)

Reaction(IUBMB)

cycloeucalenol = obtusifoliol [RN:R03775]

Reaction(KEGG)

R03775

Substrate

cycloeucalenol [CPD:C02141]

Product

obtusifoliol [CPD:C01943]

Comment

Opens the cyclopropane ring of a number of related 4alpha-methyl-9beta-19-cyclosterols, but not those with a 4beta-methyl group, with formation of an 8(9) double bond. Involved in the synthesis of plant sterols.

History

EC 5.5.1.9 created 1986

Pathway

ec00100

Steroid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K08246

cycloeucalenol cycloisomerase

Genes

ATH:	AT5G50375(CPI1)

ALY:

9301866

CRB:

17875827

CSAT:

104725142 104725553 104761032

EUS:	EUTSA_v10014300mg

BRP:	103842220 103858451

BNA:	106368587 106388428 106388470 106395079

BOE:	106311073 106334665

RSZ:	108807455 108844331

THJ:

104803145

CPAP:

110820324

CIT:

102630846

CIC:	CICLE_v10021465mg

PVY:	116116762 116120803

MINC:

123210580

TCC:

18605081

GRA:

105786328

GHI:	107941049 121232048

GAB:

108469977

HSYR:

120140161 120172208

DZI:

111289822

EGR:	104426171 120286014

GMX:	100777966 100780309

GSJ:	114409933 114416235

PVU:	PHAVU_009G167500g

VRA:

106752757

VAR:

108322558

VUN:

114196069

VUM:

124842371

CCAJ:

109797244

APRC:

113852402

MTR:

11427814

TPRA:

123897010

CAM:

101498621

PSAT:

127084734

VVO:

131661577

LJA:	Lj6g3v0984700.1(Lj6g3v0984700.1)

ADU:

107463495

AIP:	107612057 107623410

AHF:	112708166 112772166 112783263

LANG:

109326998

PCIN:

129320683

QSA:	O6P43_022565 O6P43_030741

FVE:

101310407

RCN:

112175496

PPER:

18777316

PMUM:

103338046

PAVI:

110762938

PDUL:

117629408

MDM:	103437547 103455012

MSYL:

126599463 126627368

PXB:	103938239 103950025

ZJU:

107404400

MNT:

21385761

CSAV:

115711204

CSV:

101215719

CMO:

103484362

BHJ:

120082504

MCHA:

111008866

CMAX:

111490163 111495263

CMOS:

111431284 111456735

CPEP:

111782922 111802556

RCU:

8266323

JCU:

105640216

HBR:	110665271 110671892

MESC:

110631103

POP:

7454702

PEU:

105125341

PALZ:

118057574

JRE:	108993469 108994421

CILL:

122282764 122290375

CAVE:

132176586

QSU:	112022579 112035543

QLO:	115962575 115964043

TWL:	119985894 120003718

VVI:

100262783

VRI:

117905013

SLY:	100301930(CPI)

SPEN:

107007161

SOT:

102603067

SSTN:

125862621

SDUL:

129883130

CANN:

107851175

LBB:

132604434

NTA:	107797131 107802648

NSY:

104212751

NTO:

104106158

NAU:

109235692

INI:

109158212

ITR:

115998497

SIND:

105171061

OEU:

111382474

EGT:

105970513

SSPL:

121753221 121785358

SMIL:

131010494 131010544

SHIS:

125213808

APAN:

127244057

HAN:

110879898

ECAD:

122588625

LSV:

111877353

CCAV:

112509434

DCR:	108220910 108226853

CSIN:

114309622

RVL:

131335147

AEW:	130767397 130796454

BVG:

104894046

SOE:

110787305

CQI:	110704787 110707516 110709473

ATRI:

130797692

MOF:

131159640

NNU:

104591683

MING:

122071920

TSS:	122656929 122671169

PSOM:

113274262 113278392 113281490 113316791

OSA:

9270960

DOSA:

Os11t0302500-01(Os11g0302500)

OBR:

102700845

OGL:

127755003

BDI:

100834141

ATS:	109737590 109737950 109767330 109785596

TDC:	119286681 119295069 119318216 119324494

TAES:

123086881 123091100 123096100 123123551 123128693 123134769 123145824

TUA:	125515008 125550622

LPER:

127293914

LRD:	124681258 124699553

SBI:	8071249 8071275

ZMA:

100283632

SITA:

101757137

SVS:

117850911

PVIR:

120664159 120697355

PHAI:

112886950

PDA:

103708538

EGU:	105038657 105043283 105051400

MUS:	103988675 103996747

ZOF:	122004862 122022485 122036588 122053448

DCT:

110108578

PEQ:	110028193 110039207

AOF:

109844540

MSIN:

131246316

NCOL:

116260419

ATR:

18423006

SMO:	SELMODRAFT_135190 SELMODRAFT_83343

PPP:

112291331

CRE:	CHLRE_16g657300v5

VCN:	VOLCADRAFT_109265

CSL:	COCSUDRAFT_65481

CVR:	CHLNCDRAFT_11379

APRO:

F751_6325

OLU:	OSTLU_6401

OTA:	OT_ostta04g04690

BPG:	Bathy08g04310

MIS:	MICPUN_76248

MPP:	MICPUCDRAFT_60333(JGI:MicpuC2_60333)

CME:	CYME_CMO369C

GSL:	Gasu_41820

CCP:	CHC_T00002985001

PBEL:

QC761_302790

FPOA:

FPOAC1_010342

FVN:	FVRRES_11328

FKR:	NCS57_01483300

FMU:	J7337_002278

SRE:	PTSG_06238

DDI:	DDB_G0268970

DFA:

DFA_11434

ACAN:

ACA1_220570

PTI:	PHATRDRAFT_49447

FCY:	FRACYDRAFT_189108

TPS:	THAPSDRAFT_7708

AAF:	AURANDRAFT_23404

EHX:	EMIHUDRAFT_432676 EMIHUDRAFT_444727

GTT:	GUITHDRAFT_85507

NGR:	NAEGRDRAFT_81142

» show all

Reference

1 [PMID:4369016]

Authors

Heintz R, Benveniste P.

Title

Plant sterol metabolism. Enzymatic cleavage of the 9beta, 19beta-cyclopropane ring of cyclopropyl sterols in bramble tissue cultures.

Journal

J Biol Chem 249:4267-74 (1974)

Reference

Authors

Rahier, A., Schmitt, P. and Benveniste, P.

Title

7-oxo-24xi(28)-dihydrocycloeucalenol, a potent inhibitor of plant sterol biosynthesis.

Journal

Phytochemistry 21:1969-1974 (1982)

Other DBs

ExplorEnz - The Enzyme Database:

5.5.1.9

IUBMB Enzyme Nomenclature:

5.5.1.9

ExPASy - ENZYME nomenclature database:

5.5.1.9

BRENDA, the Enzyme Database:

5.5.1.9

CAS:	60496-19-7

DBGET integrated database retrieval system