KEGG ENZYME: 5.6.1.5

ENZYME: 5.6.1.5

Entry

EC 5.6.1.5                  Enzyme

Name

proteasome ATPase

Class

Isomerases;
Isomerases altering macromolecular conformation;
Enzymes altering polypeptide conformation or assembly

Sysname

ATP phosphohydrolase (polypeptide-degrading)

Reaction(IUBMB)

ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide

Substrate

ATP [CPD:C00002];
H2O [CPD:C00001];
polypeptide [CPD:C00403]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
unfolded polypeptide

Comment

Belongs to the AAA-type superfamily and, like EC 5.6.1.4 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome.

History

EC 5.6.1.5 created 2000 as 3.6.4.8, transferred 2018 to EC 5.6.1.5

Reference

1 [PMID:9228289]

Authors

Rivett AJ, Mason GG, Murray RZ, Reidlinger J.

Title

Regulation of proteasome structure and function.

Journal

Mol Biol Rep 24:99-102 (1997)
DOI:10.1023/a:1006814306401

Reference

2 [PMID:9688553]

Authors

Mason GG, Murray RZ, Pappin D, Rivett AJ.

Title

Phosphorylation of ATPase subunits of the 26S proteasome.

Journal

FEBS Lett 430:269-74 (1998)
DOI:10.1016/S0014-5793(98)00676-0

Other DBs

ExplorEnz - The Enzyme Database:

5.6.1.5

IUBMB Enzyme Nomenclature:

5.6.1.5

ExPASy - ENZYME nomenclature database:

5.6.1.5

BRENDA, the Enzyme Database:

5.6.1.5

All links

Protein sequence (8331)   
   UniProt (71)   
   RefSeq(pep) (8260)   
DNA sequence (30150)   
   RefSeq(nuc) (26356)   
   GenBank (1973)   
   EMBL (1821)   
All databases (38481)   

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