KEGG   ENZYME: 5.6.1.8
Entry
EC 5.6.1.8                  Enzyme                                 
Name
myosin ATPase
Class
Isomerases;
Isomerases altering macromolecular conformation;
Enzymes altering polypeptide conformation or assembly
Sysname
ATP phosphohydrolase (actin-translocating)
Reaction(IUBMB)
ATP + H2O + myosin bound to actin filament at position n = ADP + phosphate + myosin bound to actin filament at position n+1
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
myosin bound to actin filament at position n
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
myosin bound to actin filament at position n+1
Comment
Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15--27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction.
History
EC 5.6.1.8 created 1984 as EC 3.6.1.32, transferred 2000 to EC 3.6.4.1, transferred 2018 to EC 5.6.1.8
Reference
1  [PMID:8663496]
  Authors
Rayment I.
  Title
The structural basis of the myosin ATPase activity.
  Journal
J Biol Chem 271:15850-3 (1996)
DOI:10.1074/jbc.271.27.15850
Reference
2  [PMID:8690736]
  Authors
Hasson T, Mooseker MS.
  Title
Vertebrate unconventional myosins.
  Journal
J Biol Chem 271:16431-4 (1996)
DOI:10.1074/jbc.271.28.16431
Reference
3  [PMID:10090768]
  Authors
Murphy CT, Spudich JA.
  Title
The sequence of the myosin 50-20K loop affects Myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity.
  Journal
Biochemistry 38:3785-92 (1999)
DOI:10.1021/bi9826815
Other DBs
ExplorEnz - The Enzyme Database: 5.6.1.8
IUBMB Enzyme Nomenclature: 5.6.1.8
ExPASy - ENZYME nomenclature database: 5.6.1.8
BRENDA, the Enzyme Database: 5.6.1.8

  All links  
Protein sequence (141)   
   UniProt (49)   
   RefSeq(pep) (86)   
   PDBSTR (6)   
DNA sequence (124)   
   RefSeq(nuc) (99)   
   GenBank (14)   
   EMBL (11)   
3D Structure (1)   
   PDB (1)   
All databases (266)   

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