KEGG   ENZYME: 6.2.1.10
Entry
EC 6.2.1.10                 Enzyme                                 
Name
carboxylic acid---CoA ligase (GDP-forming);
acyl-CoA synthetase (GDP-forming);
acyl coenzyme A synthetase (guanosine diphosphate forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
carboxylic acid:CoA ligase (GDP-forming)
Reaction(IUBMB)
GTP + a carboxylate + CoA = GDP + phosphate + acyl-CoA [RN:R00394]
Reaction(KEGG)
R00394
Substrate
GTP [CPD:C00044];
carboxylate [CPD:C00060];
CoA [CPD:C00010]
Product
GDP [CPD:C00035];
phosphate [CPD:C00009];
acyl-CoA [CPD:C00040]
History
EC 6.2.1.10 created 1972, modified 2011
Reference
1  [PMID:14213337]
  Authors
ROSSI CR, GIBSON DM.
  Title
ACTIVATION OF FATTY ACIDS BY A GUANOSINE TRIPHOSPHATE-SPECIFIC THIOKINASE FROM LIVER MITOCHONDRIA.
  Journal
J Biol Chem 239:1694-9 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.10
IUBMB Enzyme Nomenclature: 6.2.1.10
ExPASy - ENZYME nomenclature database: 6.2.1.10
BRENDA, the Enzyme Database: 6.2.1.10
CAS: 37318-59-5

  All links  
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
All databases (9)   

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