| Entry |
|
|---|
| Name |
dicarboxylate---CoA ligase;
carboxylyl-CoA synthetase;
dicarboxylyl-CoA synthetase
|
|---|
| Class |
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
|
|---|
| Sysname |
omega-dicarboxylate:CoA ligase (AMP-forming)
|
|---|
| Reaction(IUBMB) |
ATP + an alpha,omega-dicarboxylate + CoA = AMP + diphosphate + an omega-carboxyacyl-CoA [RN: R04157]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
ATP [CPD: C00002];
alpha,omega-dicarboxylate;
CoA [CPD: C00010]
|
|---|
| Product |
|
|---|
| Comment |
Acts on dicarboxylic acids of chain length C5 to C16; the best substrate is dodecanedioic acid.
|
|---|
| History |
EC 6.2.1.23 created 1989, modified 2011
|
|---|
| Reference |
|
|---|
| Authors |
Vamecq J, de Hoffmann E, Van Hoof F. |
|---|
| Title |
The microsomal dicarboxylyl-CoA synthetase. |
|---|
| Journal |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.2.1.23 |
| ExPASy - ENZYME nomenclature database: | 6.2.1.23 |
|
|---|
