KEGG ENZYME: 6.2.1.27

ENZYME: 6.2.1.27

Entry

EC 6.2.1.27                 Enzyme

Name

4-hydroxybenzoate---CoA ligase;
4-hydroxybenzoate-CoA synthetase;
4-hydroxybenzoate---coenzyme A ligase (AMP-forming);
4-hydroxybenzoyl coenzyme A synthetase;
4-hydroxybenzoyl-CoA ligase

Class

Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases

Sysname

4-hydroxybenzoate:CoA ligase (AMP-forming)

Reaction(IUBMB)

ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA [RN:R01300]

Reaction(KEGG)

R01300

Substrate

ATP [CPD:C00002];
4-hydroxybenzoate [CPD:C00156];
CoA [CPD:C00010]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-hydroxybenzoyl-CoA [CPD:C02949]

History

EC 6.2.1.27 created 1992

Pathway

ec00362

Benzoate degradation

ec00627

Aminobenzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K04105

4-hydroxybenzoate-CoA ligase

K20458

3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase

Genes

MTHD:

A3224_01560

MII:	BTJ40_01805

ADI:

B5T_02169

CRZ:	D1345_21875

CHAE:

CH06BL_45340

PBH:	AAW51_0206(badA)

EBA:	ebA727(hbcL)

ABRE:

pbN1_30670(hbcL)

APET:

ToN1_26910(hbcL)

AZI:	AzCIB_4612

AZD:	CDA09_22605

TCL:

Tchl_2972

TAK:	Tharo_1872

DDZ:	DSYM_23670

MESO:

BSQ44_18050

RPOD:

E0E05_11160

NIY:	FQ775_02940

KMN:	HW532_10710

ABAW:

D5400_06445

BJA:	blr1077(blr1077)

BJU:	BJ6T_11070

BJP:	RN69_05405

BRA:

BRADO6791

BBT:

BBta_0747

BRS:

S23_67390

AOL:

S58_06690

BRC:	BCCGELA001_34230

BIC:	LMTR13_36370

BRO:	BRAD285_6939

BRK:	CWS35_10155

BOT:	CIT37_08890

BRQ:	CIT40_30030

BGQ:	X265_34650

BGZ:	XH91_33040

BSYM:

CIT39_29155

BBET:

F8237_13035

BARH:

WN72_46160

BVZ:	BRAD3257_8649(hbaA)

BEL:	BE61_90320

BDG:	LPJ38_02130

BSEP:

HAP48_0011945

BQB:	J4P68_0015785

BSEI:

KMZ68_03440

BBAN:

J4G43_003765

BCAN:

BcanWSM471_35440

BAUT:

QA635_04845

BBRA:

QA636_04320

BGK:	IC762_32500

BCOU:

IC761_34625

BPAH:

QA639_04265

BXN:	I3J27_37575

BROS:

QUH67_33660

BRAZ:

LRP30_42145

RPA:	TX73_003465(hbaA)

RPB:

RPB_4656

RPC:

RPC_1016

RPD:	RPD_0878 RPD_1526

RPE:

RPE_0592

RPT:

Rpal_0736

RPX:	Rpdx1_4117

RBK:	E0H22_11680

VGO:	GJW-30_1_01037(hbaA)

TRB:	HB776_18425

RHZ:	RHPLAN_70010

LAP:	ACP90_01135

LABR:

CHH27_19245

LABT:

FIU93_06225(bclA1)

LAGG:

B0E33_12635

SIL:	SPO3697(badA-1)

JAN:

Jann_0669

RPON:

G3256_16625

SUAM:

BOO69_15590

SULZ:

C1J03_02525

SMED:

JNX03_11420

SPSE:

SULPSESMR1_02749(hbaA)

TOM:	BWR18_14125

RID:	RIdsm_00622(hbaA_1)

AHT:	ANTHELSMS3_04347(prpE)

SAGU:

CDO87_17715

THAA:

CFI11_22025

OCD:	FHY55_19220

MALU:

KU6B_38090

TGL:	HFZ77_06810

TRY:	QF118_10475

PTP:	RCA23_c19110

SEDI:

EBB79_19940

PPSO:

QPJ95_08515

GCE:	KYE46_09665

MAGX:

XM1_2792(bclA) XM1_3957(hcl)

MAGN:

WV31_08755 WV31_19615

MAG:	amb1551 amb2869

SUR:	STAUR_3224

» show all

Reference

1 [PMID:2914844]

Authors

Merkel SM, Eberhard AE, Gibson J, Harwood CS.

Title

Involvement of coenzyme A thioesters in anaerobic metabolism of 4-hydroxybenzoate by Rhodopseudomonas palustris.

Journal

J Bacteriol 171:1-7 (1989)
DOI:10.1128/JB.171.1.1-7.1989

Other DBs

ExplorEnz - The Enzyme Database:

6.2.1.27

IUBMB Enzyme Nomenclature:

6.2.1.27

ExPASy - ENZYME nomenclature database:

6.2.1.27

UM-BBD (Biocatalysis/Biodegradation Database):

6.2.1.27

BRENDA, the Enzyme Database:

6.2.1.27

CAS:	119699-80-8

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