KEGG ENZYME: 6.2.1.40

KEGG

ENZYME: 6.2.1.40

Entry

EC 6.2.1.40                 Enzyme

Name

4-hydroxybutyrate---CoA ligase (AMP-forming);
4-hydroxybutyrate-CoA synthetase (ambiguous);
4-hydroxybutyrate:CoA ligase (ambiguous);
hbs (gene name);
4-hydroxybutyrate---CoA ligase

Class

Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases

Sysname

4-hydroxybutanoate:CoA ligase (AMP-forming)

Reaction(IUBMB)

ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA [RN:R09279]

Reaction(KEGG)

Substrate

ATP [CPD:C00002];
4-hydroxybutanoate [CPD:C00989];
CoA [CPD:C00010]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-hydroxybutanoyl-CoA [CPD:C11062]

Comment

Isolated from the archaeon Metallosphaera sedula. Involved in the 3-hydroxypropanoate/4-hydroxybutanoate cycle. cf. EC 6.2.1.56, 4-hydroxybutyrate---CoA ligase (ADP-forming).

History

EC 6.2.1.40 created 2014, modified 2019

Pathway

Carbon fixation pathways in prokaryotes

Metabolic pathways

Microbial metabolism in diverse environments

Orthology

4-hydroxybutyrate---CoA ligase (AMP-forming)

4-hydroxybutyrate---CoA ligase (AMP-forming)

4-hydroxybutyrate---CoA ligase (AMP-forming)

4-hydroxybutyrate---CoA ligase (AMP-forming)

Genes

DLM:	DPPLL_33240

AFU:

AF_1287

AFG:	AFULGI_00013960

APO:	Arcpr_1040

GAC:

GACE_0172

IHO:

Igni_0475

IIS:

EYM_04520

IPC:

IPA_02910

PFM:	Pyrfu_1031

PABY_06060

STO:

STK_20950

SOH:	D1869_11480

SSO:	SSO1595(alkK-1)

SOL:

Ssol_2425

SULA_2450

SULB_2451

SULC_2448

J5U23_01463

SACC_13950 SACC_26260

SAI:

Saci_2146

SacN8_05595 SacN8_10445

SacRon12I_05585 SacRon12I_10700

SUSAZ_05485 SUSAZ_09795

SIS:	LS215_1135

SIA:	M1425_0518

SIM:	M1627_0847

SID:

M164_0543

SIY:	YG5714_0492

SII:

LD85_0554

SIH:

SiH_0833

SIR:

SiRe_0517

SIC:

SiL_0542

BFU36_11215

GFS03_05380

GFS33_10670

EWF20_12640

MSE:	Msed_0394 Msed_0406 Msed_1422

MJ1HA_0488 MJ1HA_0500 MJ1HA_1635

MCN:	Mcup_0813 Mcup_1674 Mcup_1685

MHK:	DFR87_04145 DFR87_04415 DFR87_11765

DFR88_04555 DFR88_04635 DFR88_11205

GWK48_03480 GWK48_07380 GWK48_07475

MJN:	MjAS7_1080 MjAS7_1095 MjAS7_2493

AHO:	Ahos_0918 Ahos_2275

B6F84_02735

DFR85_01145 DFR85_14760 DFR85_15495

DFR86_02735

D1866_06370

HS5_10870 HS5_22950

D1868_09495

KN1_05110 KN1_25190 KN1_28400

IC006_1474

RQ359_000462 RQ359_000992

PAI:

PAE2474

PIS:

Pisl_0250

PCL:

Pcal_1386

PYR:	P186_0721 P186_1145

POG:

Pogu_1296

TNE:

Tneu_0420

PYW:	PYWP30_00438

TTN:	TTX_1100(acsA)

TUZ:

TUZN_0914

Reference

1 [PMID:21169482]

Authors

Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G

Title

Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.

Journal

J Bacteriol 193:1201-11 (2011)
DOI:10.1128/JB.01156-10

Sequence

[tne:Tneu_0420]

Reference

2 [PMID:23258541]

Authors

Hawkins AS, Han Y, Bennett RK, Adams MW, Kelly RM

Title

Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea.

Journal

J Biol Chem 288:4012-22 (2013)
DOI:10.1074/jbc.M112.413195

Sequence

[mse:Msed_0406]

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

DBGET integrated database retrieval system