Entry
Name
3-oxocholest-4-en-26-oate---CoA ligase;
fadD19 (gene name)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
(25S)-3-oxocholest-4-en-26-oate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + (25S)-3-oxocholest-4-en-26-oate + CoA = AMP + diphosphate + (25S)-3-oxocholest-4-en-26-oyl-CoA [RN:
R10770 ]
Reaction(KEGG)
Substrate
Product
AMP [CPD:
C00020 ];
diphosphate [CPD:
C00013 ];
(25S)-3-oxocholest-4-en-26-oyl-CoA [CPD:
C20840 ]
Comment
The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol. It is responsible for the activation of the C8 side chain. 3beta-hydroxycholest-5-en-26-oate can also be used as substrate.
History
EC 6.2.1.42 created 2014
Orthology
K18688 3-oxocholest-4-en-26-oate---CoA ligase
Genes
DOE : DENOEST_1059(fadD) DENOEST_2572(fadD)
CAUL : KCG34_06270 KCG34_14640
PHB : HYN04_07985 HYN04_08445
SPHK : SKP52_13335 SKP52_24420
SMAG : AN936_14240 AN936_23785
SGI : SGRAN_0469 SGRAN_1179 SGRAN_1605(fadD19)
SPHO : C3E99_01885 C3E99_02355
SFLA : SPHFLASMR4Y_00423(prpE) SPHFLASMR4Y_02314(prpE)
SPHY : CHN51_00265 CHN51_05335
PHZ : CHX26_03665 CHX26_05405
POT : E2E27_04720 E2E27_05245
MTO : MTCTRI2_3579(fadD19)
MBO : BQ2027_MB3544C(fadD19)
MBM : BCGMEX_3576c(fadD19)
MPA : MAP_0550(fadD19) MAP_2380(fadD19) MAP_2388c(fadD19)
MAO : MAP4_1435 MAP4_1443 MAP4_3317
MAVI : RC58_07115 RC58_07155 RC58_16450
MAVU : RE97_07115 RE97_07155 RE97_16485
MAV : MAV_0644 MAV_1592 MAV_1600
MIT : OCO_05530 OCO_16570 OCO_16690
MIA : OCU_05580 OCU_16770 OCU_16890
MID : MIP_01013 MIP_02290 MIP_02304
MYO : OEM_05610 OEM_14570 OEM_14690
MCHI : AN480_02765 AN480_08155 AN480_08215
MIR : OCQ_05690 OCQ_14250 OCQ_14370
MMAL : CKJ54_02695 CKJ54_07015 CKJ54_07075
MMAN : MMAN_25030 MMAN_25160 MMAN_48490(fadD19)
MSA : Mycsm_02113 Mycsm_02128 Mycsm_05748
MUL : MUL_3279 MUL_3870(fadD19_2) MUL_4075(fadD19_1)
MMI : MMAR_2064 MMAR_4007(fadD19_2) MMAR_4013 MMAR_5001(fadD19_1)
MMAE : MMARE11_20070 MMARE11_38140(fadD19_2) MMARE11_48110(fadD19_1)
MLI : MULP_02244 MULP_04172(fadD19_2) MULP_04178 MULP_05249(fadD19_1)
MPSE : MPSD_20960 MPSD_39710 MPSD_51990(fadD19)
MSHO : MSHO_04670(fadD19) MSHO_51040
MMC : Mmcs_1775 Mmcs_1786 Mmcs_2891 Mmcs_4627
MKM : Mkms_1822 Mkms_1833 Mkms_2935 Mkms_4715
MJL : Mjls_1756 Mjls_1767 Mjls_2921 Mjls_5009
MMM : W7S_02715 W7S_06955 W7S_07015
MKN : MKAN_06070 MKAN_09620 MKAN_11735 MKAN_22955 MKAN_25740
MYV : G155_04840 G155_10770 G155_10840 G155_15435 G155_16740 G155_23265
MYE : AB431_00500 AB431_25020 AB431_26250
MDX : BTO20_15255 BTO20_24115 BTO20_24170 BTO20_31085
MSHG : MSG_01920 MSG_03595 MSG_03606 MSG_04501(fadD19)
MFJ : MFLOJ_07140 MFLOJ_13380 MFLOJ_41220(fadD19) MFLOJ_50790 MFLOJ_50890
MSTO : MSTO_08490 MSTO_14790 MSTO_45210(fadD19) MSTO_54980
MSIM : MSIM_04310 MSIM_29610(fadD19) MSIM_40420 MSIM_40500
MSAK : MSAS_00180 MSAS_18570 MSAS_18860 MSAS_28580(fadD19) MSAS_57080
MKU : I2456_10195 I2456_19045 I2456_25395
MLW : MJO58_10410 MJO58_19705 MJO58_19780 MJO58_24805
MXE : MYXE_06320(fadD19) MYXE_16990 MYXE_17040
MNV : MNVI_02850 MNVI_02930 MNVI_11970(fadD19)
MPAG : C0J29_11885 C0J29_22035 C0J29_22085 C0J29_27440
MNM : MNVM_24320 MNVM_26850 MNVM_27150 MNVM_36400
MGOR : H0P51_07365 H0P51_20010 H0P51_20065 H0P51_21800 H0P51_25490 H0P51_27805 H0P51_27835
MCOO : MCOO_16490 MCOO_16660 MCOO_26520(fadD19)
MBAI : MB901379_01889 MB901379_03486 MB901379_03494 MB901379_04394
MSEO : MSEO_07150 MSEO_23860 MSEO_23970 MSEO_33970(fadD19)
MHEK : JMUB5695_00531(fadD19) JMUB5695_01765 JMUB5695_01773
MGAU : MGALJ_04390 MGALJ_04520 MGALJ_37760
MLJ : MLAC_00270(fadD19) MLAC_10260
MBRD : MBRA_02250 MBRA_20570(fadD19) MBRA_31650 MBRA_31790 MBRA_58070 MBRA_58170
MMAM : K3U93_15215 K3U93_17130 K3U93_17170 K3U93_21425 K3U93_22370
MOT : LTS72_00095 LTS72_05160 LTS72_14290 LTS72_14450 LTS72_17135
MPAA : MKK62_02700 MKK62_07655 MKK62_07720
MKY : IWGMT90018_37230 IWGMT90018_41910 IWGMT90018_41990 IWGMT90018_56700(fadD19)
MADI : A7U43_07115 A7U43_14945 A7U43_21075 A7U43_21155
MWU : PT015_00710 PT015_09280 PT015_09395 PT015_15260
MSM : MSMEG_2231 MSMEG_2241 MSMEG_3687 MSMEG_5914
MSG : MSMEI_2177(fadD19) MSMEI_2188 MSMEI_3600 MSMEI_5754(fadD19)
MSB : LJ00_11105 LJ00_11160 LJ00_18330 LJ00_29245
MSN : LI99_11105 LI99_11160 LI99_18335 LI99_29250
MSH : LI98_11110 LI98_11165 LI98_18340 LI98_29255
MVA : Mvan_1995 Mvan_2010 Mvan_5215
MGI : Mflv_1543 Mflv_4335 Mflv_4349
MSP : Mspyr1_09270 Mspyr1_36800 Mspyr1_36980
MCB : Mycch_1739 Mycch_1752 Mycch_4576
MNE : D174_03230 D174_16020 D174_24120
MYN : MyAD_03155 MyAD_15740 MyAD_23660
MFT : XA26_09300 XA26_22160 XA26_22300 XA26_34290
MPHL : MPHLCCUG_00593 MPHLCCUG_01907 MPHLCCUG_01924
MVQ : MYVA_1893 MYVA_1909 MYVA_5099(fadD19_1)
MLL : B1R94_00535 B1R94_24780
MRH : MycrhN_2319 MycrhN_6046 MycrhN_6062
MTHN : 4412656_01433 4412656_01448 4412656_02213 4412656_04032
MHAS : MHAS_00825 MHAS_00842 MHAS_03700
MDU : MDUV_24900 MDUV_25050 MDUV_49930
MCHT : MCHIJ_09990 MCHIJ_20160 MCHIJ_21060 MCHIJ_21200
MAUU : NCTC10437_01838 NCTC10437_01867 NCTC10437_04977
MMAG : MMAD_30880 MMAD_47750
MMOR : MMOR_01320 MMOR_01410 MMOR_12500 MMOR_44850 MMOR_44980
MFX : MFAL_25980 MFAL_33790 MFAL_34760
MAIC : MAIC_05980 MAIC_07610 MAIC_55610
MIJ : MINS_07000 MINS_42160 MINS_43030
MALV : MALV_05730 MALV_16820 MALV_16960 MALV_43050
MTY : MTOK_12820 MTOK_23130
MPSC : MPSYJ_16510 MPSYJ_46350
MARZ : MARA_10370 MARA_48680
MGAD : MGAD_19580 MGAD_19730 MGAD_36840
MHEV : MHEL_21070 MHEL_28440(fadD19) MHEL_29920 MHEL_39580
MSAR : MSAR_10340 MSAR_16920
MANY : MANY_26380 MANY_32380 MANY_37310
MAUB : MAUB_12020 MAUB_13890 MAUB_26050
MPOF : MPOR_23270 MPOR_23450 MPOR_53160
MPHU : MPHO_00790 MPHO_44290
MMUC : C1S78_017980 C1S78_025140
MMAT : MMAGJ_35090 MMAGJ_51600 MMAGJ_51690 MMAGJ_67160
MBOK : MBOE_03690 MBOE_40100 MBOE_52860 MBOE_52990
MFG : K6L26_05845 K6L26_15155 K6L26_21540 K6L26_21615
MSEI : MSEDJ_01730 MSEDJ_41440
MFLV : NCTC10271_00537 NCTC10271_03527 NCTC10271_03592
MCEE : MCEL_17580 MCEL_17730 MCEL_38530
MMON : EWR22_09015 EWR22_15305 EWR22_25025
MGO : AFA91_11180 AFA91_21470
MHOL : K3U96_03425 K3U96_17800 K3U96_17885
MSEN : K3U95_07545 K3U95_14210 K3U95_19040 K3U95_19115 K3U95_24985
MPAE : K0O64_00480 K0O64_24715 K0O64_25740
MRF : MJO55_09075 MJO55_23795
MDF : K0O62_09825 K0O62_09875 K0O62_25310
MCRO : MI149_01005 MI149_26050
MGRO : FZ046_02510 FZ046_19675
MKR : MKOR_02430 MKOR_36020(fadD19)
MPAK : MIU77_02300 MIU77_05470 MIU77_05580 MIU77_10410 MIU77_10530
MIZ : BAB75_20730 BAB75_22885 BAB75_23830
MJD : JDM601_2408 JDM601_3360(fadD19_2) JDM601_3390 JDM601_3648(fadD19_1)
MTER : 4434518_02338 4434518_03346(fadD19_2) 4434518_03376 4434518_03622(fadD19_1)
MMIN : MMIN_01140 MMIN_10540 MMIN_11770
MHIB : MHIB_18610 MHIB_27810 MHIB_28060 MHIB_30460
MHER : K3U94_13635 K3U94_19160 K3U94_19285 K3U94_20630
MVM : MJO54_13425 MJO54_19120 MJO54_19240 MJO54_20560
NBR : O3I_002930 O3I_020185
NNO : NONO_c03470 NONO_c05390 NONO_c32970 NONO_c33060 NONO_c38820 NONO_c43920
NSL : BOX37_02385 BOX37_22105
NSR : NS506_00416 NS506_01306 NS506_01309 NS506_02683 NS506_02684
NOZ : DMB37_00305 DMB37_23825
NOD : FOH10_28465 FOH10_29795
NAD : NCTC11293_01290 NCTC11293_04157
NWL : NWFMUON74_05350(fadD19) NWFMUON74_28880
NIE : KV110_03245 KV110_20615
NTC : KHQ06_03420 KHQ06_07775
NHU : H0264_02980 H0264_04070 H0264_04085 H0264_26535
NYA : LTV02_28550 LTV02_28670 LTV02_29765
NGP : LTT66_00995 LTT66_15740
NSPU : IFM12276_02360 IFM12276_41730
NYU : D7D52_03665 D7D52_04715 D7D52_04730
RHA : RHA1_ro04675 RHA1_ro04689(fadD19) RHA1_ro10299
RER : RER_04580(fadD) RER_09360(fadD19) RER_33730 RER_51730(fadD) RER_53370
REY : O5Y_02195 O5Y_04175 O5Y_15540 O5Y_24465 O5Y_25335
REB : XU06_02400 XU06_04420 XU06_15775 XU06_24885 XU06_25685
RQI : C1M55_02495 C1M55_04655 C1M55_16790 C1M55_26085 C1M55_26885
ROP : ROP_47740(fadD) ROP_47880(fadD19)
ROA : Pd630_LPD01181 Pd630_LPD01195
RAV : AAT18_04190 AAT18_22230
RRZ : CS378_12020 CS378_19820
RHOD : AOT96_05895 AOT96_06880 AOT96_12950 AOT96_15060 AOT96_26975
RRT : 4535765_00661(fadD19)
RCR : NCTC10994_02062(fadD19)
RKO : JWS14_25900 JWS14_25970
RGO : KYT97_05630 KYT97_15720 KYT97_21905 KYT97_24380
ROZ : CBI38_04940 CBI38_05005
RPSK : JWS13_18530 JWS13_18600
RGOR : NMQ04_02915 NMQ04_08035
REQ : REQ_07350 REQ_13860 REQ_36170 REQ_43880
PDEF : P9209_01790 P9209_05520 P9209_28800
WHR : OG579_07770 OG579_09255 OG579_17565
GPO : GPOL_c25330 GPOL_c41480 GPOL_c42730
GOR : KTR9_0795 KTR9_3892(fadD19)
GOQ : ACH46_03155 ACH46_17425
GTA : BCM27_04360 BCM27_20410
GRU : GCWB2_04070 GCWB2_19895
GOM : D7316_02594 D7316_04524
GAV : C5O27_00970 C5O27_08225
GOD : GKZ92_03820 GKZ92_18815
GAM : GII34_06215 GII34_19560 GII34_19850 GII34_20150 GII34_20230
GPD : GII33_02620 GII33_02645 GII33_02945 GII33_03300
GJI : H1R19_03770 H1R19_18755
GOI : LK459_05245 LK459_13855
GHN : MVF96_04135 MVF96_19330
GAMI : IHQ52_06710 IHQ52_22830
GMG : NWF22_06295 NWF22_15315
GSI : P5P27_01250 P5P27_15915
SPIN : KV203_13635 KV203_13705 KV203_17145
DTM : BJL86_0674 BJL86_0678 BJL86_2458 BJL86_3087
DIZ : CT688_03095 CT688_12035
DPC : A6048_03040 A6048_03395 A6048_12575
DLU : A6035_03340 A6035_03645 A6035_11660
DKN : NHB83_02890 NHB83_03225 NHB83_12025
TOY : FO059_01365 FO059_05020 FO059_14030
SGRF : SGFS_008810 SGFS_099500
SLS : SLINC_0577 SLINC_7434
SFEU : IM697_26065 IM697_28310
SAKB : K1J60_39165 K1J60_42665
SOV : QZH56_00205 QZH56_32300
SFIY : F0344_07375 F0344_33655
YIA : LO772_02660 LO772_25930 LO772_27755
MWA : E4K62_16790 E4K62_17580
MCAW : F6J84_13340 F6J84_14295
MBIN : LXM64_14095 LXM64_15015
MELY : L2X98_24755 L2X98_29190
NARO : CFH99_06225 CFH99_13295
NPC : KUV85_04460 KUV85_17150
NMAR : HPC71_09720 HPC71_13650 HPC71_14665
NFC : KG111_03540 KG111_08620
PSIM : KR76_14210 KR76_21465
TCU : Tcur_0691 Tcur_3496 Tcur_3980 Tcur_4748
ACTW : F7P10_13525 F7P10_22090 F7P10_26225
AGRA : AGRA3207_002837 AGRA3207_004371
AMAZ : LUW76_17500 LUW76_28505 LUW76_32225
ACIR : OG979_13060 OG979_19825 OG979_24585
SPIQ : OHA34_17770 OHA34_18015 OHA34_24905 OHA34_24975 OHA34_27360
NFS : OIE67_15750 OIE67_39825
FRI : FraEuI1c_1369 FraEuI1c_1935 FraEuI1c_5056
AJA : AJAP_26145(fadD19) AJAP_28550
AMQ : AMETH_3173 AMETH_3762 AMETH_4814
AACD : LWP59_22695 LWP59_28995
PAUT : Pdca_48200 Pdca_65400
PPEL : H6H00_20405 H6H00_29265
ABAI : IMCC26256_111261 IMCC26256_111379 IMCC26256_111846 IMCC26256_112054
AYM : YM304_15600 YM304_24080 YM304_31200 YM304_35190
ATQ : GH723_02270 GH723_02405 GH723_06495 GH723_09705 GH723_10650
AQZ : KSP35_00645 KSP35_01185 KSP35_04590 KSP35_07195 KSP35_07205 KSP35_09110 KSP35_09215 KSP35_13515
IAM : HC251_05225 HC251_11530 HC251_13675 HC251_13680 HC251_15155 HC251_16360 HC251_17885 HC251_17955 HC251_19690 HC251_19840
IMA : PO878_09775 PO878_09780 PO878_10220 PO878_11215 PO878_15200 PO878_16655 PO878_16735 PO878_16800 PO878_17430
DHI : LH044_00400 LH044_02695 LH044_05285 LH044_07305 LH044_09670 LH044_09705 LH044_16670 LH044_18295
» show all
Taxonomy
Reference
Authors
Wilbrink MH, Petrusma M, Dijkhuizen L, van der Geize R
Title
FadD19 of Rhodococcus rhodochrous DSM43269, a steroid-coenzyme A ligase essential for degradation of C-24 branched sterol side chains.
Journal
Sequence
Reference
Authors
Casabon I, Swain K, Crowe AM, Eltis LD, Mohn WW
Title
Actinobacterial acyl coenzyme A synthetases involved in steroid side-chain catabolism.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.42
ExPASy - ENZYME nomenclature database: 6.2.1.42