| Entry |
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| Name |
medium-chain-fatty-acid---[acyl-carrier-protein] ligase;
jamA (gene name)
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| Class |
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
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| Sysname |
medium-chain-fatty-acid:[acyl-carrier protein] ligase (AMP-forming)
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| Reaction(IUBMB) |
ATP + a medium-chain fatty acid + a holo-[acyl-carrier protein] = AMP + diphosphate + a medium-chain acyl-[acyl-carrier protein] [RN: R12148]
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| Reaction(KEGG) |
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| Substrate |
ATP [CPD: C00002];
medium-chain fatty acid [CPD: C21925];
holo-[acyl-carrier protein] [CPD: C00229]
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| Product |
AMP [CPD: C00020];
diphosphate [CPD: C00013];
medium-chain acyl-[acyl-carrier protein] [CPD: C21927]
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| Comment |
The enzyme ligates medium chain fatty acids (with aliphatic chain of 6-12 carbons) to an acyl-carrier protein.
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| History |
EC 6.2.1.47 created 2016
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| Orthology |
| K21107 | medium-chain-fatty-acid---[acyl-carrier-protein] ligase |
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| Reference |
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| Authors |
Edwards DJ, Marquez BL, Nogle LM, McPhail K, Goeger DE, Roberts MA, Gerwick WH |
|---|
| Title |
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. |
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| Journal |
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| Sequence |
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| Reference |
|
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| Authors |
Zhu X, Liu J, Zhang W |
|---|
| Title |
De novo biosynthesis of terminal alkyne-labeled natural products. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.2.1.47 |
| ExPASy - ENZYME nomenclature database: | 6.2.1.47 |
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