KEGG   ENZYME: 6.2.1.60
Entry
EC 6.2.1.60                 Enzyme                                 
Name
marinolic acid---CoA ligase;
tmlU (gene name)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
marinolic acid:CoA ligase (AMP-forming)
Reaction(IUBMB)
(1) ATP + a marinolic acid + CoA = AMP + diphosphate + a marinoloyl-CoA [RN:R12494];
(2) ATP + a pseudomonic acid + CoA = AMP + diphosphate + a pseudomonoyl-CoA [RN:R12495]
Reaction(KEGG)
R12494 R12495
Substrate
ATP [CPD:C00002];
marinolic acid [CPD:C22211];
CoA [CPD:C00010];
pseudomonic acid [CPD:C22213]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
marinoloyl-CoA [CPD:C22212];
pseudomonoyl-CoA [CPD:C22214]
Comment
The enzyme, characterized from the bacterium Pseudoalteromonas sp. SANK 73390, catalyses the CoA acylation of pseudomonic and marinolic acids, as part of the biosynthesis of thiomarinols and related compounds.
History
EC 6.2.1.60 created 2019
Orthology
K23875  marinolic acid---CoA ligase
Reference
1  [PMID:25726835]
  Authors
Dunn ZD, Wever WJ, Economou NJ, Bowers AA, Li B
  Title
Enzymatic basis of "hybridity" in thiomarinol biosynthesis.
  Journal
Angew Chem Int Ed Engl 54:5137-41 (2015)
DOI:10.1002/anie.201411667
  Sequence
[ag:CBK62739]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.60
IUBMB Enzyme Nomenclature: 6.2.1.60
ExPASy - ENZYME nomenclature database: 6.2.1.60
BRENDA, the Enzyme Database: 6.2.1.60

  All links  
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG REACTION (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (6)   
   InterPro (6)   
All databases (19)   

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