KEGG   ENZYME: 6.2.1.63
Entry
EC 6.2.1.63                 Enzyme                                 
Name
L-arginine---[L-arginyl-carrier protein] ligase;
vabF (gene name)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
L-arginine:[L-arginyl-carrier protein] ligase (AMP-forming)
Reaction(IUBMB)
ATP + L-arginine + holo-[L-arginyl-carrier protein] = AMP + diphosphate + L-arginyl-[L-arginyl-carrier protein] (overall reaction);
(1a) ATP + L-arginine = diphosphate + (L-arginyl)adenylate [RN:R12572];
(1b) (L-arginyl)adenylate + holo-[L-arginyl-carrier protein] = AMP + L-arginyl-[L-arginyl-carrier protein]
Reaction(KEGG)
R12572;
(other) R12573 R12574
Substrate
ATP [CPD:C00002];
L-arginine [CPD:C00062];
holo-[L-arginyl-carrier protein];
(L-arginyl)adenylate [CPD:C22264]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
L-arginyl-[L-arginyl-carrier protein];
(L-arginyl)adenylate [CPD:C22264]
Comment
The adenylation domain of the enzyme catalyses the activation of L-arginine to (L-arginyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.
History
EC 6.2.1.63 created 2020
Orthology
K24101  L-arginine---[L-arginyl-carrier protein] ligase
Genes
YELLC20_00744
YFRAW19_2624
YKRCH54_3164
YRUBD65_1348
YRBUGYR_07465
YMADA391_07275
YHID5F51_19215
YCAF0T03_18530
YASN0H69_06335
YKIHRD70_01325
YEGPL78_09730
SMARSM39_1905
SMACSMDB11_1729
SMWSMWW4_v1c24620
SMAFD781_2012
SERFL085_16425
SRZAXX16_3117
SERMCLM71_10250
SFJSAMEA4384070_1829(dhbF_3)
SSURATE40_008995
SURIJ0X03_11630
SRHZFO014_23395
SNEMNLX84_12450
PRODPCO85_14695
SERASer39006_010855
SERQCWC46_10850
PWAPecwa_3733
PPARA8F97_00005
PECW5S_3874
PWSA7983_03710
DDDDda3937_03038
DZEDd1591_1322
DDCDd586_2813
DZCW909_13770
DSOA4U42_02230
CEDLH89_19430
DFNCVE23_15095
DDQDDI_2787
DAQDAQ1742_01263(cbsF)
DICDpoa569_001071
DLCO1Q98_05345
DDADd703_1494
BNGEH206_19940
LBQCKQ53_17080
LPOPI6N93_11265
EPECI789_04430
ERWIGN242_07960
ERPLJN55_09050
PANSFCN45_21745
MINTC7M51_02065(lgrD)
MTHIC7M52_00776(lgrD)
XBOXBJ1_1441
XBVXBW1_1500
XHOA9255_12790
XGRQL128_17865
VAGN646_0834
VANVAA_02398
LAGN175_10475
VGABSQ33_15340
VQICCZ37_04330
VSRVspart_01407(lgrD_3)
VRURND59_14990
SPRON7E60_04720
ANORR32_09180
ACALBUM88_09525
ASEII8T81_09875
ACDAOLE_09920
ASHAG8E00_09295
MTHDA3224_14710
HCHHCH_03818
HAHEENC22_13310
HAHHO5O45_08460
MMEMarme_1356
MPCMar181_2157
MPRIMP3633_2427
MFOIJSY38_03010
MRHIKDW99_13010
GSNYC6258_02697
CVICV_2233(cbsF)
CVCBKX93_01150
CHROCXB49_11680
CHRIDK842_18525
CHRBDK843_01185
CARIFNU76_12990
JABVN23_17090
MASYDPH57_08225
MASZC9I28_13420
MPLIE1742_00985
TCTPX653_09410
EHBE7V67_011065
XDIEZH22_22235
BVRBVIR_3121
MSCBN69_2716(dhbF)
MROSEHO51_17305
ABSAZOBR_p350078 AZOBR_p350079
ABQABAZ39_25750
ABFAMK58_23105
AZTTSH58p_23470
AARED3093_24665
 » show all
Reference
1  [PMID:17159203]
  Authors
Balado M, Osorio CR, Lemos ML
  Title
A gene cluster involved in the biosynthesis of vanchrobactin, a chromosome-encoded siderophore produced by Vibrio anguillarum.
  Journal
Microbiology 152:3517-3528 (2006)
DOI:10.1099/mic.0.29298-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.63
IUBMB Enzyme Nomenclature: 6.2.1.63
ExPASy - ENZYME nomenclature database: 6.2.1.63
BRENDA, the Enzyme Database: 6.2.1.63

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