KEGG ENZYME: 6.3.2.42

ENZYME: 6.3.2.42

Entry

EC 6.3.2.42                 Enzyme

Name

N-acetylaspartylglutamylglutamate synthase;
N-acetylaspartylglutamylglutamate synthetase;
NAAG(2) synthase;
NAAG synthetase II;
NAAGS-II;
RIMKLA (gene name) (ambiguous)

Class

Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)

Sysname

N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamyl-L-glutamate-forming)

Reaction(IUBMB)

2 ATP + N-acetyl-L-aspartate + 2 L-glutamate = 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate [RN:R10679]

Reaction(KEGG)

R10679;
(other) R10678 R10693

Substrate

ATP [CPD:C00002];
N-acetyl-L-aspartate [CPD:C01042];
L-glutamate [CPD:C00025]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
N-acetyl-L-aspartyl-L-glutamyl-L-glutamate [CPD:C20776]

Comment

The enzyme, found in mammals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.

History

EC 6.3.2.42 created 2014

Pathway

ec00250

Alanine, aspartate and glutamate metabolism

ec01100

Metabolic pathways

Orthology

K18311

N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase

Genes

HSA:	284716(RIMKLA)

PTR:	748944(RIMKLA)

PPS:	100970527(RIMKLA)

GGO:	101137769(RIMKLA)

PON:	100457877(RIMKLA)

NLE:	100589997(RIMKLA)

HMH:	116463700 116463727

MCC:	699767(RIMKLA)

MCF:	102128755(RIMKLA)

MTHB:

126959995

MNI:	105494839(RIMKLA)

CSAB:

103225007(RIMKLA)

CATY:

105594671(RIMKLA)

PANU:

101017885(RIMKLA)

TGE:	112631615(RIMKLA)

MLEU:

105555114(RIMKLA)

RRO:	104668996(RIMKLA)

RBB:	108530380(RIMKLA)

TFN:	117092770(RIMKLA)

PTEH:

111548818(RIMKLA)

CANG:

105513879(RIMKLA)

CJC:	100400904(RIMKLA)

SBQ:	101028223(RIMKLA)

CIMI:

108313389(RIMKLA)

CSYR:

103269612(RIMKLA)

MMUR:

105862291(RIMKLA)

LCAT:

123634283(RIMKLA)

PCOQ:

105812355(RIMKLA)

OGA:	100962508(RIMKLA)

MMU:	194237(Rimkla)

MCAL:

110293598(Rimkla)

MPAH:

110323614(Rimkla)

MCOC:

116096541(Rimkla)

ANU:	117709313(Rimkla)

MUN:	110547458(Rimkla)

CGE:	100759423(Rimkla)

MAUA:

101843711(Rimkla)

PROB:

127225276(Rimkla)

PLEU:

114704934(Rimkla)

MORG:

121448391(Rimkla)

MFOT:

126513197

AAMP:

119818063(Rimkla)

NGI:	103735994(Rimkla)

HGL:	101721728(Rimkla)

CPOC:

100713055(Rimkla)

CCAN:

109702396(Rimkla)

DORD:

105986036(Rimkla)

DSP:	122111270(Rimkla)

PLOP:

125354285(Rimkla)

NCAR:

124969199

MMMA:

107141636(Rimkla)

OCU:

100356205

OPI:	101536112(RIMKLA)

TUP:	102474653(RIMKLA)

GVR:	103602407(RIMKLA)

CFA:	482445(RIMKLA)

CLUD:

112642267(RIMKLA)

VVP:	112908198(RIMKLA)

VLG:	121481599(RIMKLA)

NPO:	129520538(RIMKLA)

AML:	100472546(RIMKLA)

UMR:	103670923(RIMKLA)

UAH:	113254814(RIMKLA)

UAR:	123793822(RIMKLA)

ELK:

111143454

LLV:

125098454

MPUF:

101690597(RIMKLA)

MNP:	132000685(RIMKLA)

MLK:	131809477(RIMKLA)

NVS:	122899834(RIMKLA)

ORO:	101368732(RIMKLA)

EJU:	114224206(RIMKLA)

ZCA:	113919895(RIMKLA)

MLX:	118019547(RIMKLA)

NSU:	110575430(RIMKLA)

LWW:	102733401(RIMKLA)

FCA:	101099388(RIMKLA)

PYU:	121026952(RIMKLA)

PCOO:

112863341(RIMKLA)

PBG:	122480352(RIMKLA)

PVIV:

125173105(RIMKLA)

LRUF:

124514137

PTG:	102959348(RIMKLA)

PPAD:

109254893(RIMKLA)

PUC:

125912708

AJU:

106970196

HHV:	120236090(RIMKLA)

BTA:	507323(RIMKLA)

BOM:	102285876(RIMKLA)

BIU:	109556903(RIMKLA)

BBUB:

102407086(RIMKLA)

BBIS:

105004897(RIMKLA)

CHX:	102179728(RIMKLA)

OAS:	101104941(RIMKLA)

BTAX:

128044673(RIMKLA)

ODA:	120856323(RIMKLA)

CCAD:

122437135(RIMKLA)

MBEZ:

129541522(RIMKLA)

SSC:	100522878(RIMKLA)

CFR:	102522941(RIMKLA)

CBAI:

105072857(RIMKLA)

CDK:	105105491(RIMKLA)

VPC:	102545512(RIMKLA)

BACU:

103018606(RIMKLA)

BMUS:

118886232(RIMKLA)

LVE:	103083571(RIMKLA)

OOR:	101275823(RIMKLA)

DLE:	111175673(RIMKLA)

PCAD:

102982103(RIMKLA)

PSIU:

116762902(RIMKLA)

NASI:

112399558(RIMKLA)

ECB:	100067475(RIMKLA)

EPZ:	103557317(RIMKLA)

EAI:	106847814(RIMKLA)

MYB:	102249129(RIMKLA)

MYD:	102754710(RIMKLA)

MMYO:

118677485(RIMKLA)

MLF:	102430712(RIMKLA)

PKL:	118723941(RIMKLA)

EFUS:

103294846(RIMKLA)

MNA:	107531164(RIMKLA)

DRO:	112299564(RIMKLA)

SHON:

118977580(RIMKLA)

AJM:	119052488(RIMKLA)

PDIC:

114497212(RIMKLA)

PHAS:

123831998(RIMKLA)

MMF:	118627179(RIMKLA)

PPAM:

129069083(RIMKLA)

HAI:	109383339(RIMKLA)

RFQ:	117027770(RIMKLA)

PALE:

102882758(RIMKLA)

PGIG:

120607199(RIMKLA)

PVP:	105304029(RIMKLA)

RAY:	107508299(RIMKLA)

MJV:	108403838(RIMKLA)

TOD:	119236219(RIMKLA)

SARA:

101544446(RIMKLA)

SETR:

126011165(RIMKLA)

LAV:	100664484(RIMKLA)

TMU:

101348075

ETF:	101661935(RIMKLA)

DNM:	101421529(RIMKLA)

MDO:	100026482(RIMKLA)

GAS:	123243217(RIMKLA)

SHR:	100913508(RIMKLA)

AFZ:

127555543

PCW:	110206227(RIMKLA)

OAA:	100073839(RIMKLA)

XLA:

108696583

XTR:	100145548(rimkla)

NPR:	108783941(RIMKLA)

RTEM:

120915609(RIMKLA)

BBUF:

120998179(RIMKLA)

BGAR:

122926877(RIMKLA)

» show all

Reference

1 [PMID:21454531]

Authors

Lodder-Gadaczek J, Becker I, Gieselmann V, Wang-Eckhardt L, Eckhardt M

Title

N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.

Journal

J Biol Chem 286:16693-706 (2011)
DOI:10.1074/jbc.M111.230136

Sequence

[mmu:194237] [hsa:284716]

Other DBs

ExplorEnz - The Enzyme Database:

6.3.2.42

IUBMB Enzyme Nomenclature:

6.3.2.42

ExPASy - ENZYME nomenclature database:

6.3.2.42

BRENDA, the Enzyme Database:

6.3.2.42

DBGET integrated database retrieval system