KEGG   ENZYME: 6.3.2.44
Entry
EC 6.3.2.44                 Enzyme                                 
Name
pantoate---beta-alanine ligase (ADP-forming);
pantothenate synthetase (ambiguous);
pantoate---beta-alanine ligase (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
(R)-pantoate:beta-alanine ligase (ADP-forming)
Reaction(IUBMB)
ATP + (R)-pantoate + beta-alanine = ADP + phosphate + (R)-pantothenate [RN:R10821]
Reaction(KEGG)
R10821
Substrate
ATP [CPD:C00002];
(R)-pantoate [CPD:C00522];
beta-alanine [CPD:C00099]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
(R)-pantothenate [CPD:C00864]
Comment
The enzyme, characterized from the archaeon Methanosarcina mazei, is involved in the biosynthesis of pantothenate. It is different from EC 6.3.2.1, the AMP-forming pantoate-beta-alanine ligase found in bacteria and eukaryota.
History
EC 6.3.2.44 created 2014
Reference
1  [PMID:18422645]
  Authors
Ronconi S, Jonczyk R, Genschel U
  Title
A novel isoform of pantothenate synthetase in the Archaea.
  Journal
FEBS J 275:2754-64 (2008)
DOI:10.1111/j.1742-4658.2008.06416.x
  Sequence
[mma:MM_2281]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.44
IUBMB Enzyme Nomenclature: 6.3.2.44
ExPASy - ENZYME nomenclature database: 6.3.2.44
BRENDA, the Enzyme Database: 6.3.2.44

  All links  
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Protein sequence (1)   
   UniProt (1)   
DNA sequence (6)   
   GenBank (3)   
   EMBL (3)   
All databases (16)   

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