KEGG ENZYME: 6.3.2.57

ENZYME: 6.3.2.57

Entry

EC 6.3.2.57                 Enzyme

Name

staphyloferrin A synthase;
sfnaB (gene name)

Class

Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)

Sysname

N5-[(S)-citryl]-D-ornithine:citrate ligase (staphyloferrin A-forming)

Reaction(IUBMB)

ATP + N5-[(S)-citryl]-D-ornithine + citrate = AMP + diphosphate + staphyloferrin A [RN:R12354]

Reaction(KEGG)

R12354

Substrate

ATP [CPD:C00002];
N5-[(S)-citryl]-D-ornithine [CPD:C22101];
citrate [CPD:C00158]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013];
staphyloferrin A [CPD:C22102]

Comment

Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation.

History

EC 6.3.2.57 created 2019

Pathway

ec00997

Biosynthesis of various other secondary metabolites

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K23447

staphyloferrin A synthase

Genes

LPN:	lpg1325(frgA)

LPH:	LPV_1432(FrgA)

LPO:	LPO_1303(FrgA)

LPU:	LPE509_01881

LPM:	LP6_1307(frgA)

LPF:

lpl1279

LPP:

lpp1280

LPC:	LPC_0740(frgA)

LPA:

lpa_01955

LPE:

lp12_1263

LLO:	LLO_3129(FrgA)

LHA:	LHA_3006(FrgA)

LCD:	clem_01380(iucC)

LSH:	CAB17_02135

LLG:	44548918_02520(iucC)

LGT:	E4T54_08065

SDO:	SD1155_00625

BWH:	A9C19_09105

BARD:

QRY57_10050

GCT:	GC56T3_0421

GJF:	M493_02170

GSR:	GS3922_13790

HHD:	HBHAL_4881(figA)

HLI:

HLI_03745

SJE:	AAV35_000860

SA1981

SAV:

SAV2179

SAW:

SAHV_2163

SAH:	SaurJH1_2249

SAJ:	SaurJH9_2210

SAM:

MW2105

SAS:

SAS2080

SAR:

SAR2270

SAC:

SACOL2169

SAX:	USA300HOU_2171

SAA:	SAUSA300_2138

SAO:	SAOUHSC_02434

SAE:

NWMN_2080

SAD:

SAAV_2240

SUU:	M013TW_2145(sfaB)

SUV:	SAVC_09765

SUE:	SAOV_2226c

SUJ:	SAA6159_02090(sfaB)

SUK:	SAA6008_02217

SUC:	ECTR2_2040

SUT:	SAT0131_02348

SUQ:	HMPREF0772_11012

SUZ:

MS7_2202

SUD:	ST398NM01_2239

SUX:	SAEMRSA15_20840

SUW:	SATW20_23140

SUG:

SAPIG2239

SUF:	SARLGA251_19740

SAUA:

SAAG_00014

SAUE:

RSAU_002023

SAUN:

SAKOR_02147

SAUS:

SA40_1934

SAUU:

SA957_2018

SAUG:

SA268_2089

SAUZ:

SAZ172_2280

SAUT:

SAI1T1_2016210

SAUJ:

SAI2T2_1016220

SAUK:

SAI3T3_1016210

SAUQ:

SAI4T8_1016220

SAUV:

SAI7S6_1016210

SAUW:

SAI5S5_1016150

SAUX:

SAI6T6_1016160

SAUY:

SAI8T7_1016190

SAUF:

X998_2164

SAB:

SAB2060c

SUY:	SA2981_2117

SAUB:

C248_2217

SAUM:

BN843_22190

SAUC:

CA347_2264

SAUR:

SABB_01483

SAUI:

AZ30_11520

SAUD:

CH52_08050

SAMS:

NI36_10760

SUH:	SAMSHR1132_20110

SER:

SERP1779

SEP:

SE_1770

SEPP:

SEB_01779

SEPS:

DP17_723

SHA:

SH0861

SHH:	ShL2_00754

SSP:

SSP0707

SCA:

SCA_1682

SLG:	SLGD_00838

SLN:	SLUG_08960

SSD:	SPSINT_1841

SDT:

SPSE_0634

SDP:	NCTC12225_00707(iucC_2)

SWA:	A284_03590

SPAS:

STP1_0608

SXY:	BE24_08450

SXL:	SXYLSMQ121_0739

SXO:	SXYL_00749(sfaB)

SHU:	SHYC_03405

SCAP:

AYP1020_1372(iucA)

SSCH:

LH95_03230

SSCZ:

RN70_03505

SAGQ:

EP23_06670

SEQO:

SE1039_18700

SSIF:

AL483_01430

SCV:	A4G25_11715

SPET:

CEP67_04915 CEP67_08225

SLZ:	B5P37_02890

SCOH:

BZ166_07960

SNL:	BJD96_03860

SKL:	C7J89_05040

SFQ:	C7J90_00580

SHOM:

EGX58_07745

SMUS:

C7J88_05160

SCAR:

DWB96_03755

SCHR:

DWB92_03205

SARL:

SAP2_07760

SPIC:

SAMEA4384060_0849(iucA)

SSH:	NCTC13712_02124(iucA_2)

SSIM:

SAMEA4384339_2024(iucC_1)

SDB:	CNQ82_10375

SLLO:

ISP08_03705

SAUL:

I6G39_03105

SSAC:

I6I31_00925

SRAI:

LN051_02925

SPSD:

JMB28_04195

STAS:

HYI43_04045

SURY:

MUA21_09200

SEDA:

MNY58_03760

SCAQ:

QMO72_03705

SDEV:

Q2T90_03615

SROT:

ML435_10450

STAP:

AOB58_2564

SSCU:

CEP64_13505

SFF:	FOB90_04535

SSTE:

SAMEA4384403_0110(iucC) SAMEA4384403_0111(iucA)

MVT:	I6J10_10595

PANA:

BBH88_03995

PANC:

E2636_16090

ASE:

ACPL_4368

AMS:	AMIS_41860

ACTN:

L083_3994

ACTS:

ACWT_4239

PFLA:

Pflav_024190

PSUU:

Psuf_079590

PRY:	Prubr_61740

CATI:

CS0771_66370

SNA:

Snas_3733

NAV:	JQS30_07795 JQS30_07800

GLY:	K3N28_09090

FPC:	FPSM_02589

FPY:	FPG101_12935

FPQ:	IB65_12400

FPV:	IA03_12175

FPW:	IA04_12060

FPK:	IA06_12135

» show all

Reference

1 [PMID:19138128]

Authors

Cotton JL, Tao J, Balibar CJ

Title

Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.

Journal

Biochemistry 48:1025-35 (2009)
DOI:10.1021/bi801844c

Other DBs

ExplorEnz - The Enzyme Database:

6.3.2.57

IUBMB Enzyme Nomenclature:

6.3.2.57

ExPASy - ENZYME nomenclature database:

6.3.2.57

BRENDA, the Enzyme Database:

6.3.2.57

DBGET integrated database retrieval system