KEGG   ENZYME: 6.3.2.59
Entry
EC 6.3.2.59                 Enzyme                                 
Name
3-methyl-D-ornithine---L-lysine ligase;
N6-[(2R,3R)-3-methylornithyl]-L-lysine synthase;
3-methylornithine---L-lysine ligase;
pylC (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
(3R)-3-methyl-D-ornithine:L-lysine gamma-ligase (ADP-forming)
Reaction(IUBMB)
ATP + (3R)-3-methyl-D-ornithine + L-lysine = ADP + phosphate + N6-[(3R)-3-methyl-D-ornithinyl]-L-lysine [RN:R10011]
Reaction(KEGG)
R10011
Substrate
ATP [CPD:C00002];
(3R)-3-methyl-D-ornithine [CPD:C20277];
L-lysine [CPD:C00047]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
N6-[(3R)-3-methyl-D-ornithinyl]-L-lysine [CPD:C20278]
Comment
The enzyme participates in the biosynthesis of L-pyrrolysine, a naturally occurring, genetically coded amino acid found in some methanogenic archaea and a few bacterial species. L-pyrrolysine is present in several methyltransferases that are involved in methyl transfer from methylated amine compounds to coenzyme M.
History
EC 6.3.2.59 created 2021
Pathway
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16181  3-methylornithine--L-lysine ligase
Genes
DSY: DSY4957
DHD: Dhaf_4856
DDH: Desde_0575
DOR: Desor_1624 Desor_3053
DMI: Desmer_1593
DAE: Dtox_0029
FWA: DCMF_28150 DCMF_28350
AACX: DEACI_4243
TJR: TherJR_0024
DGI: Desgi_3924
ELIM: B2M23_05180
WHJ: H9Q79_07360(pylC)
AMIJ: EQM06_09280(pylC)
AMIC: Ami3637_11540(pylC)
ABUT: Ami103574_12090(pylC)
ETM: CE91St48_13130
TPZ: Tph_c24760
AAR: Acear_0359
MANA: MAMMFC1_01956
MBA: Mbar_A0837
MBY: MSBRM_0157
MBW: MSBRW_0164
MBAR: MSBR2_2224
MBAK: MSBR3_2275
MAC: MA_0153
MMA: MM_1443
MMAZ: MmTuc01_1501
MMJ: MSMAS_3221
MMAC: MSMAC_3243
MVC: MSVAZ_3359
MEK: MSKOL_3318
MLS: MSLAZ_3209
METM: MSMTP_3121
MEF: MSWH1_3070
MEQ: MSWHS_3281
MSJ: MSSAC_0135
MSZ: MSSIH_0122
MSW: MSSIT_0126
MTHR: MSTHT_1932
MTHE: MSTHC_1351
MHOR: MSHOH_3967
MFZ: AOB57_008960(pylC)
MBU: Mbur_2084(pylC)
MMET: MCMEM_0283
MELO: J7W08_11510(pylC)
MMH: Mmah_0281
MHAZ: BHR79_02115
MPOT: BKM01_06290
MEV: Metev_0936
MZH: Mzhil_1027
MPY: Mpsy_1723
MZI: HWN40_00975(pylC)
MMAV: RE476_10050(pylC)
MSEB: RE474_06595(pylC)
MHZ: Metho_0020
MEHF: MmiHf6_12400
MEES: MmiEs2_14450
MEAM: MU439_03275
MEAE: QEN48_07095
TAR: TALC_01090
MAX: MMALV_11270
MER: MMINT_08910
MEAR: Mpt1_c05680(pylC)
MEUZ: KRP56_05615(pylC)
MARC: AR505_1323
 » show all
Reference
1  [PMID:21455182]
  Authors
Gaston MA, Zhang L, Green-Church KB, Krzycki JA
  Title
The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine.
  Journal
Nature 471:647-50 (2011)
DOI:10.1038/nature09918
Reference
2  [PMID:21525873]
  Authors
Cellitti SE, Ou W, Chiu HP, Grunewald J, Jones DH, Hao X, Fan Q, Quinn LL, Ng K, Anfora AT, Lesley SA, Uno T, Brock A, Geierstanger BH.
  Title
D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine.
  Journal
Nat Chem Biol 7:528-30 (2011)
DOI:10.1038/nchembio.586
Reference
3  [PMID:22985965]
  Authors
Quitterer F, List A, Beck P, Bacher A, Groll M.
  Title
Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
  Journal
J Mol Biol 424:270-82 (2012)
DOI:10.1016/j.jmb.2012.09.007
  Sequence
[mba:Mbar_A0837]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.59
IUBMB Enzyme Nomenclature: 6.3.2.59
ExPASy - ENZYME nomenclature database: 6.3.2.59
BRENDA, the Enzyme Database: 6.3.2.59

  All links  
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (92)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (67)   
   KEGG MGENES (24)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (3)   
Protein domain (4)   
   InterPro (4)   
All databases (116)   

Download RDF
DBGET integrated database retrieval system