KEGG ENZYME: 6.3.3.7

ENZYME: 6.3.3.7

Entry

EC 6.3.3.7                  Enzyme

Name

Ni-sirohydrochlorin a,c-diamide reductive cyclase;
cfbC (gene name);
cfbD (gene name)

Class

Ligases;
Forming carbon-nitrogen bonds;
Cyclo-ligases

Sysname

Ni-sirohydrochlorin a,c-diamide reductive cyclo-ligase (ADP-forming)

Reaction(IUBMB)

ATP + Ni-sirohydrochlorin a,c-diamide + 3 reduced electron acceptor + H2O = ADP + phosphate + 15,173-seco-F430-173-acid + 3 electron acceptor [RN:R11628]

Reaction(KEGG)

R11628

Substrate

ATP [CPD:C00002];
Ni-sirohydrochlorin a,c-diamide [CPD:C21511];
reduced electron acceptor;
H2O [CPD:C00001]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512];
electron acceptor

Comment

The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.

History

EC 6.3.3.7 created 2017

Pathway

ec00860

Porphyrin metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

ec01120

Microbial metabolism in diverse environments

Orthology

K21610

Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC

K21611

Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD

Genes

MJA:

MJ_1423

MFE:	Mefer_1398

MVU:	Metvu_0736

MFS:	MFS40622_0630

MIF:	Metin_0570

MJH:	JH146_0545

MESG:

MLAUSG7_0646(cfbD)

MESA:

MLASG1_0179(cfbD)

MIG:	Metig_1723

MMP:

MMP0428

MMQ:	MmarC5_1209

MMX:	MmarC6_0483

MMZ:	MmarC7_1425

MMD:

GYY_02215

MMAK:

MMKA1_04480

MMAO:

MMOS7_04440

MMAD:

MMJJ_06040

MAE:

Maeo_1313

MVN:	Mevan_1413

MVO:

Mvol_1630

MOK:	Metok_0580

METF:

CFE53_05865

MTH:	MTH_1522 MTH_643

MMG:	MTBMA_c01050 MTBMA_c10230(nifH2)

MWO:	MWSIV6_0061 MWSIV6_1015(nifH2)

MTEE:

MTTB_06850 MTTB_15090

METC:

MTCT_0570 MTCT_1386

METE:

tca_00613(nifH1_1) tca_01470(nifD_1)

METZ:

METMT2_0422 METMT2_1600

METK:

FVF72_04015 FVF72_08355(cfbC)

MTHM:

FZP57_00245 FZP57_04835(cfbC)

METJ:

FZP68_01455 FZP68_05275(cfbC)

MST:	Msp_1120(nifH) Msp_1461

METB:

AW729_08130 AW729_10175

MEIS:

PXD04_02060(cfbC) PXD04_03055(cfbD)

MRU:	mru_0181 mru_1466

MSI:	Msm_1160 Msm_1707

MEB:	Abm4_0121 Abm4_0733

MMIL:

sm9_0152 sm9_1376

MEYE:

TL18_04160 TL18_10060

MOL:	YLM1_0966 YLM1_1498

MARO:

MarbSA_02330 MarbSA_10930

METV:

K4897_00070(cfbC) K4897_05595(cfbD)

MEL:	Metbo_0037 Metbo_2093

MEW:	MSWAN_0064 MSWAN_0543

METH:

MBMB1_0045 MBMB1_0311(nifH2)

MFC:	BRM9_0099 BRM9_1962

MFI:	DSM1535_0151(nifH2-1) DSM1535_1422

MCUB:

MCBB_0063 MCBB_0533(nifH2)

MSUB:

BK009_10140 BK009_11725

METN:

BK008_05605 BK008_07360

METT:

CIT01_00825(nifH) CIT01_06000

METO:

CIT02_05310 CIT02_06840

MEME:

HYG87_02415(cfbC) HYG87_06895(cfbD)

MFEG:

GCM10025860_08150 GCM10025860_11910

MFV:	Mfer_0362 Mfer_0380

MKA:	MK1385(nifD)

MBA:	Mbar_A0346 Mbar_A0347

MBY:	MSBRM_0572 MSBRM_0573

MBW:	MSBRW_0650 MSBRW_0651

MBAR:

MSBR2_1806 MSBR2_1807

MBAK:

MSBR3_2861 MSBR3_2862

MAC:	MA_3627(nifH) MA_3628

MMA:	MM_0514(nifH2) MM_0515

MMAZ:

MmTuc01_0532 MmTuc01_0533

MMJ:	MSMAS_0791 MSMAS_0792

MMAC:

MSMAC_0770 MSMAC_0771

MVC:	MSVAZ_3046 MSVAZ_3047

MEK:	MSKOL_2991 MSKOL_2992

MLS:	MSLAZ_2304 MSLAZ_2305

METM:

MSMTP_0886 MSMTP_0887

MEF:	MSWH1_2457 MSWH1_2458

MEQ:	MSWHS_2585 MSWHS_2586

MSJ:	MSSAC_1227 MSSAC_1228

MSZ:	MSSIH_2813 MSSIH_2814

MSW:	MSSIT_2847 MSSIT_2848

MTHR:

MSTHT_2450 MSTHT_2451

MTHE:

MSTHC_0831 MSTHC_0832

MHOR:

MSHOH_0894 MSHOH_0895

MFZ:	AOB57_003165(cfbC) AOB57_003170

MBU:	Mbur_1037 Mbur_1038

MMET:

MCMEM_1519 MCMEM_1520

MELO:

J7W08_06405(cfbD) J7W08_06410(cfbC)

MMH:	Mmah_1412 Mmah_1413

MHAZ:

BHR79_06610 BHR79_06615

MPOT:

BKM01_02855 BKM01_02860

MEV:	Metev_0555 Metev_0556

MZH:	Mzhil_0468 Mzhil_0469

MPY:	Mpsy_0958 Mpsy_0959

MZI:	HWN40_03735(cfbD) HWN40_03740(cfbC)

MMAV:

RE476_06475(cfbC) RE476_06480(cfbD)

MSEB:

RE474_02030(cfbD) RE474_02035(cfbC)

MHZ:	Metho_0542 Metho_0543

MEHF:

MmiHf6_07010(nifH1) MmiHf6_07020

MEES:

MmiEs2_02360(nifH1) MmiEs2_02370

MTP:	Mthe_0106 Mthe_1178

MCJ:	MCON_0503(nifH) MCON_1930

MHI:	Mhar_0047 Mhar_2391

MHU:

Mhun_0670

MRTJ:

KHC33_10020(cfbD)

MLA:

Mlab_0520

MEM:	Memar_1733

MBG:	BN140_0718

MCHK:

MchiMG62_19350

MSUM:

OH143_02895(cfbD)

MRC:	R6Y96_04905(cfbD)

MPI:

Mpet_1002

MEND:

L6E24_12095(cfbD)

MEFW:

F1737_06050

MAQE:

RJ40_03895

MFK:	E2N92_04050

MOU:	OU421_12235(cfbD)

MESB:

L1S32_04115(cfbD)

MANQ:

L1994_05910(cfbD)

MBN:

Mboo_1419

MFO:	Metfor_1748

MPL:

Mpal_0679

MPD:	MCP_0363 MCP_0364(nifH-1)

MEZ:	Mtc_0063 Mtc_0064(nifH-1)

RCI:	RCIX2002(nifH-2) RCIX2003

MELU:

MTLP_03850

MEAM:

MU439_05075 MU439_05080(cfbD)

MEAE:

QEN48_05075(cfbD) QEN48_05080

TAR:	TALC_01251

MAX:	MMALV_13210

MER:	MMINT_17220 MMINT_17230

MEAR:

Mpt1_c08020(bchB2)

MEUZ:

KRP56_02460(cfbD)

MARC:

AR505_0362

» show all

Reference

1 [PMID:3691535]

Authors

Pfaltz A, Kobelt A, Huster R, Thauer RK

Title

Biosynthesis of coenzyme F430 in methanogenic bacteria. Identification of 15,17(3)-seco-F430-17(3)-acid as an intermediate.

Journal

Eur J Biochem 170:459-67 (1987)
DOI:10.1111/j.1432-1033.1987.tb13722.x

Reference

2 [PMID:27846569]

Authors

Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO

Title

The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.

Journal

Science 354:339-342 (2016)
DOI:10.1126/science.aag2947

Sequence

[mac:MA_3627 MA_3628]

Other DBs

ExplorEnz - The Enzyme Database:

6.3.3.7

IUBMB Enzyme Nomenclature:

6.3.3.7

ExPASy - ENZYME nomenclature database:

6.3.3.7

BRENDA, the Enzyme Database:

6.3.3.7

DBGET integrated database retrieval system