KEGG ENZYME: 6.3.4.12

ENZYME: 6.3.4.12

Entry

EC 6.3.4.12                 Enzyme

Name

glutamate---methylamine ligase;
gamma-glutamylmethylamide synthetase

Class

Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases

Sysname

L-glutamate:methylamine ligase (ADP-forming)

Reaction(IUBMB)

ATP + L-glutamate + methylamine = ADP + phosphate + N5-methyl-L-glutamine [RN:R01585]

Reaction(KEGG)

R01585

Substrate

ATP [CPD:C00002];
L-glutamate [CPD:C00025];
methylamine [CPD:C00218]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
N5-methyl-L-glutamine [CPD:C03153]

History

EC 6.3.4.12 created 1972

Orthology

K01949

glutamate---methylamine ligase

Genes

GAI:	IMCC3135_28060(glnT)

TSN:	W908_01950

THIN:

CRN91_08145(glnT)

MLN:	A9174_29115

MCI:	Mesci_5156

MCIC:

A4R28_01320

MOP:	Mesop_5739

MAM:	Mesau_05234

MAMO:

A6B35_11075

MESW:

A9K65_028265

MESM:

EJ066_15675(glnT)

MESP:

C1M53_18730(glnT)

MHUA:

MCHK_0827(glnT)

MJR:	EB229_29695(glnT)

MERD:

EB233_25740(glnT)

MOH:	IHQ72_30475(glnT)

MMEI:

LRP31_29835(glnT)

AAK:	AA2016_5807

AMIH:

CO731_05434(glnT)

AMIS:

Amn_pa02960

ANJ:	AMD1_PA0294(gmas)

PHT:	BLM14_24665

RPOD:

E0E05_05945(glnT)

SMK:	Sinme_3421

SMQ:	SinmeB_3196

SMX:	SM11_chr3561(glnT)

SMI:	BN406_03224(glnT)

SMEG:

C770_GR4Chr0097

SMEL:

SM2011_c02613(glnT)

SMER:

DU99_00490

SMD:	Smed_3294 Smed_6005

RHI:	NGR_c14410(glnT)

SFH:	SFHH103_06333(glnT)

SIX:	BSY16_5797(glnT)

SAME:

SAMCFNEI73_pC1024

EAK:	EKH55_4303

ENU:	PYH37_001921(glnT)

SKM:	PZL22_003705(glnT)

AGR:	AGROH133_12302

ATF:	Ach5_36150(glnA)

AGC:	BSY240_3620(glnT)

AVI:	Avi_5752(glnA)

REC:	RHECIAT_PA0000334(glnT)

REL:	REMIM1_PD00440(glnT)

REP:	IE4803_PA00370(glnT)

REI:	IE4771_PC00383(glnT)

RLT:	Rleg2_5641

RLG:

Rleg_6578

RLB:	RLEG3_05400

RLU:	RLEG12_01965

RTR:	RTCIAT899_PC09295(glnT)

RHL:	LPU83_pLPU83c0694(glnT)

RGA:	RGR602_PC01860(glnT)

RHN:	AMJ98_PD00425(glnT)

RPHA:

AMC79_PB00339(glnT)

RHX:	AMK02_PE00432(glnT)

RHK:	Kim5_PB00401(glnT)

REZ:	AMJ99_PC00426(glnT)

RJG:	CCGE525_22845(glnT)

RHR:	CKA34_31840(glnT)

RII:	FFM53_030605(glnT)

RHID:

FFM81_029950(glnT)

RLN:	J0663_26870(glnT)

RBAN:

J2J98_25880(glnT)

RRG:	J3P73_30920(glnT)

RLS:	HB780_09410(glnT)

RROS:

D4A92_02875(glnT)

RAW:	NE851_05405(glnT)

RSUL:

N2599_22135(glnT)

RRHO:

PR018_16880(glnT)

RTU:	PR017_16765(glnT)

ARA:	Arad_8367(glnT)

ARO:	B0909_19475(glnT)

SOJ:	K6301_16505(glnT)

PDES:

FE840_000855(glnT)

BRA:	BRADO5882(glnA)

BBT:	BBta_1945(glnA)

RPB:

RPB_1135

TRB:	HB776_20420(glnT)

BVV:	BHK69_09835

XAU:

Xaut_4698

XDI:	EZH22_24765(glnT)

AZC:

AZC_1499

STAR:

G3545_13135(glnT)

LNE:	FZC33_23790(glnT)

SNO:

Snov_0455

ANC:	GBB76_17685(glnT)

APRA:

G3A50_15290(glnT)

APOL:

K9D25_00540(glnT)

MEA:	Mex_1p1553

MDI:

METDI2327

MEX:

Mext_1659

MCH:

Mchl_1941

MPO:

Mpop_1572

MZA:	B2G69_15955

MRD:	Mrad2831_4807

META:

Y590_07820

MAQU:

Maq22A_c07630(glnA)

METD:

C0214_09530(glnT) C0214_27320(glnT)

METX:

A3862_04395

METS:

DK389_06155(glnT)

MMES:

MMSR116_29790(glnT)

MIND:

mvi_52000(glnT)

MOG:	MMB17_10265(glnT)

MSL:

Msil_2635

MTUN:

MTUNDRAET4_2822(glnT) MTUNDRAET4_3084

MLG:	CWB41_02760(glnT) CWB41_16065(glnT)

BBAR:

RHAL1_02575(glnT)

HDN:

Hden_0515

HDT:	HYPDE_25078

HMC:	HYPMC_4366(gmas)

HNI:	W911_11235

FIL:	BN1229_v1_1169(glnT)

FIY:	BN1229_v1_1168(glnT)

MCG:

GL4_0799

METG:

HT051_11880(glnT)

CMET:

K6K41_10835(glnT)

PLEO:

OHA_1_03153(glnT)

HDI:	HDIA_3398(glnT)

MEY:	TM49_12285

AUZ:	Sa4125_08460

JIE:	OH818_23845(glnT)

NOH:	G5V57_07095(glnT)

TSO:

IZ6_30310

LIZ:	LGH83_08105(glnT)

SIL:	SPO1573(glnT)

RCON:

K3740_20105(glnT)

RDE:	RD1_4250(glnT)

RLI:	RLO149_c005820(glnT)

RPON:

G3256_12400(glnT)

DSH:	Dshi_1867(glnT)

OAR:	OA238_c26820

LMD:	METH_18430

LEJ:	ETW24_17950(glnT)

LAQU:

R2C4_19755(glnT)

LEV:	ETW23_00210(glnT)

LCAE:

K3721_16220(glnT)

RED:	roselon_03567

CID:

P73_0133

CEH:	CEW89_17265(glnT)

MALG:

MALG_00923

YAN:	AYJ57_19000

TPRO:

Ga0080559_TMP4880 Ga0080559_TMP4892

PABY:

Ga0080574_TMP1115 Ga0080574_TMP4713

SULZ:

C1J03_14650(glnT)

SULI:

C1J05_06630(glnT)

SPSE:

SULPSESMR1_03830(glnT)

RMM:	ROSMUCSMR3_00030(glnT)

ROK:	RAK1035_2880

RID:	RIdsm_02435(glnT)

ROM:	EI983_08250(glnT)

ROH:	FIU89_08615(glnT) FIU89_17915(glnA3)

RPEL:

N7U68_14565(glnT)

MALU:

KU6B_39960

PALX:

GQA70_20895(glnT) GQA70_23260(glnT)

RHP:	LPB142_05665

PAMI:

JCM7686_pAMI6p105

PYE:	A6J80_01560(glnT)

PZH:	CX676_01700(glnT)

PAMN:

pAMV1p0109(gmaS)

PSAP:

JHX88_20435(glnT)

PALP:

JHW40_18670(glnT)

PVER:

E3U25_19545(glnT)

PFEO:

E3U26_07505(glnT)

PTP:	RCA23_c23640(glnA3)

RHC:

RGUI_3209

DAA:	AKL17_0252

RBG:	BG454_15455(glnT)

GEH:	HYN69_07415(glnT)

GFU:	KM031_03470(glnT)

TAW:	EI545_08515(glnT)

PPRU:

FDP22_15455(glnT)

PAED:

G5B38_09610(glnT)

PAMO:

BAR1_12125(glnT)

FAP:	GR316_12280(glnT)

AMYL:

QBD29_01410(glnT)

PBAE:

P8S53_06965(glnT)

FAQ:	G5B39_16775(glnT)

RDI:	CMV14_00745(glnT)

SSAN:

NX02_15580

GTI:	FXF46_11725(glnT)

GBE:	GbCGDNIH1_2110

GBH:	GbCGDNIH2_2110

GBC:	GbCGDNIH3_2110

GBS:	GbCGDNIH4_2110

GXL:	H845_1584 H845_92

KEU:	S101446_00798(glnA)

KSC:	CD178_01529(glnT)

KOI:	LV478_11175(glnT)

AACE:

A0U92_02370

ACEK:

FLP30_07220(glnT)

RAP:	RHOA_2529(glnT)

ACIM:

GT370_04425(glnT)

NGU:	QN315_14230(glnT)

SHUM:

STHU_53950(glnT)

SVC:	STVA_53790(glnT)

STEL:

STAQ_48960

AZL:	AZL_a09540(glnA)

RPM:	RSPPHO_02176(glnA1)

HTQ:	FRZ44_30250

HADH:

FRZ61_17270

TII:	DY252_08035(glnT)

THAI:

IT893_13225(glnT)

TTB:	MACH01_26240(glnT)

NACI:

NUH88_18350(glnT)

PUB:	SAR11_1316(glnT)

PEG:	E5R92_06670(glnT)

APC:	HIMB59_00013170

APM:	HIMB5_00009560

APB:	SAR116_1707

ACOP:

RI196_06350(glnT)

FAL:	FRAAL1887(glnIII)

SYU:	M744_04820

CYB:	CYB_1005(glnA-1)

SYNE:

Syn6312_3383

SYNP:

Syn7502_02094

SYNC:

CB0101_01845(glnT)

DSL:	Dacsa_3567

CGC:	Cyagr_1005

CYI:	CBM981_0307(glnT)

CMP:	Cha6605_0263

CYN:	Cyan7425_0282

LEN:	LEP3755_41240

LET:	O77CONTIG1_00575(glnT_1)

LBO:

LBWT_8910

HHG:	XM38_027690(glnA_1)

PSER:

ABRG53_0397(glnA)

THEU:

HPC62_14825(glnT)

GLP:	Glo7428_3065

ENN:	FRE64_06535(glnT)

PLS:	VT03_09265(glnT)

SOH:	D1869_05950(glnT)

» show all

Reference

1 [PMID:5800436]

Authors

Kung HF, Wagner C.

Title

Gamma-glutamylmethylamide. A new intermediate in the metabolism of methylamine.

Journal

J Biol Chem 244:4136-40 (1969)

Other DBs

ExplorEnz - The Enzyme Database:

6.3.4.12

IUBMB Enzyme Nomenclature:

6.3.4.12

ExPASy - ENZYME nomenclature database:

6.3.4.12

BRENDA, the Enzyme Database:

6.3.4.12

CAS:	37318-69-7

DBGET integrated database retrieval system