KEGG   ENZYME: 6.3.4.25
Entry
EC 6.3.4.25                 Enzyme                                 
Name
2-amino-2'-deoxyadenylo-succinate synthase;
purZ (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
Sysname
dGMP:L-aspartate ligase (ADP-forming)
Reaction(IUBMB)
ATP + dGMP + L-aspartate = ADP + phosphate + 2-amino-2'-deoxy-N6-[(2S)-succino]adenylate [RN:R12786]
Reaction(KEGG)
R12786
Substrate
ATP [CPD:C00002];
dGMP [CPD:C00362];
L-aspartate [CPD:C00049]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
2-amino-2'-deoxy-N6-[(2S)-succino]adenylate [CPD:C22395]
Comment
The enzyme, characterized from a number of bacteriophages, participates in the biosynthesis of dZTP, which replaces dATP in the genome of these phages.
History
EC 6.3.4.25 created 2021
Pathway
ec00230  Purine metabolism
Orthology
K24972  Vibrio phage 2-amino-2'-deoxyadenylo-succinate synthase
Reference
1  [PMID:33926954]
  Authors
Zhou Y, Xu X, Wei Y, Cheng Y, Guo Y, Khudyakov I, Liu F, He P, Song Z, Li Z, Gao Y, Ang EL, Zhao H, Zhang Y, Zhao S
  Title
A widespread pathway for substitution of adenine by diaminopurine in phage genomes.
  Journal
Science 372:512-516 (2021)
DOI:10.1126/science.abe4882
Reference
2  [PMID:33926955]
  Authors
Sleiman D, Garcia PS, Lagune M, Loc'h J, Haouz A, Taib N, Rothlisberger P, Gribaldo S, Marliere P, Kaminski PA.
  Title
A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes.
  Journal
Science 372:516-520 (2021)
DOI:10.1126/science.abe6494
  Sequence
[vg:24366411]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.25
IUBMB Enzyme Nomenclature: 6.3.4.25
ExPASy - ENZYME nomenclature database: 6.3.4.25
BRENDA, the Enzyme Database: 6.3.4.25

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (6)   
Protein sequence (124)   
   UniProt (120)   
   SWISS-PROT (4)   
Protein domain (5)   
   InterPro (5)   
All databases (145)   

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