KEGG   ENZYME: 6.3.4.8
Entry
EC 6.3.4.8                  Enzyme                                 
Name
imidazoleacetate---phosphoribosyldiphosphate ligase;
5-phosphoribosylimidazoleacetate synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
Sysname
imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)
Reaction(IUBMB)
ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate + H2O = ADP + phosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + diphosphate [RN:R04068]
Reaction(KEGG)
R04068
Substrate
ATP [CPD:C00002];
imidazole-4-acetate [CPD:C02835];
5-phosphoribosyl diphosphate [CPD:C00119];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
1-(5-phosphoribosyl)imidazole-4-acetate [CPD:C04437];
diphosphate [CPD:C00013]
History
EC 6.3.4.8 created 1972
Pathway
ec00340  Histidine metabolism
Reference
1  [PMID:14235540]
  Authors
CROWLEY GM.
  Title
THE ENZYMATIC SYNTHESIS OF 5'-PHOSPHORIBOSYLIMIDAZOLEACETIC ACID.
  Journal
J Biol Chem 239:2593-601 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.8
IUBMB Enzyme Nomenclature: 6.3.4.8
ExPASy - ENZYME nomenclature database: 6.3.4.8
BRENDA, the Enzyme Database: 6.3.4.8
CAS: 37318-65-3

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
All databases (12)   

Download RDF
DBGET integrated database retrieval system