KEGG   ENZYME: 6.3.5.12
Entry
EC 6.3.5.12                 Enzyme                                 
Name
Ni-sirohydrochlorin a,c-diamide synthase;
cfbB (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Carbon-nitrogen ligases with glutamine as amido-N-donor
Sysname
Ni-sirohydrochlorin:L-glutamine amido-ligase (ADP-forming)
Reaction(IUBMB)
2 ATP + Ni-sirohydrochlorin + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + Ni-sirohydrochlorin a,c-diamide + 2 L-glutamate [RN:R11627]
Reaction(KEGG)
R11627
Substrate
ATP [CPD:C00002];
Ni-sirohydrochlorin [CPD:C21510];
L-glutamine [CPD:C00064];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Ni-sirohydrochlorin a,c-diamide [CPD:C21511];
L-glutamate [CPD:C00025]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.3.5.12 created 2017
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K22012  Ni-sirohydrochlorin a,c-diamide synthase
Genes
MBA: Mbar_A0348
MBY: MSBRM_0571
MBW: MSBRW_0649
MBAR: MSBR2_1808
MBAK: MSBR3_2863
MAC: MA_3626(cbiA2)
MMA: MM_0513
MMJ: MSMAS_0793
MMAC: MSMAC_0772
MVC: MSVAZ_3045
MEK: MSKOL_2993
MLS: MSLAZ_2306
METM: MSMTP_0885
MEF: MSWH1_2459
MEQ: MSWHS_2584
MSJ: MSSAC_1229
MSZ: MSSIH_2815
MSW: MSSIT_2849
MTHR: MSTHT_2452
MTHE: MSTHC_0830
MHOR: MSHOH_0896
MFZ: AOB57_003160(cfbB)
MBU: Mbur_1039(cbiA_cobB)
MMET: MCMEM_1521
MELO: J7W08_06415(cfbB)
MMH: Mmah_1414
MHAZ: BHR79_06605
MPOT: BKM01_02850
MEV: Metev_0554
MZH: Mzhil_0467
MPY: Mpsy_0957
MZI: HWN40_03745(cfbB)
MMAV: RE476_06470(cfbB)
MSEB: RE474_02040(cfbB)
MHZ: Metho_0541
MEHF: MmiHf6_07000(cbiA_2)
MEES: MmiEs2_02350(cbiA_1)
MTP: Mthe_1179
MCJ: MCON_0502(cobB1)
MHI: Mhar_0046
MHU: Mhun_0671
MRTJ: KHC33_10015(cfbB)
MLA: Mlab_0521
MEM: Memar_1734
MBG: BN140_0717(cobB)
MCHK: MchiMG62_19360
MSUM: OH143_02900(cfbB)
MRC: R6Y96_04900(cfbB)
MPI: Mpet_1003
MEND: L6E24_12090(cfbB)
MEFW: F1737_06045(cfbB)
MAQE: RJ40_03890(cfbB)
MFK: E2N92_04045(cfbB)
MOU: OU421_12240(cfbB)
MESB: L1S32_04120(cfbB)
MANQ: L1994_05905(cfbB)
MBN: Mboo_1420
MFO: Metfor_1747
MPL: Mpal_0678
MPD: MCP_0365(cobB)
MEZ: Mtc_0065(cbiA-1)
RCI: RCIX2001(cbiA-1)
MELU: MTLP_01910
MEAM: MU439_05070(cfbB)
MEAE: QEN48_05085(cfbB)
 » show all
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3626]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.5.12
IUBMB Enzyme Nomenclature: 6.3.5.12
ExPASy - ENZYME nomenclature database: 6.3.5.12
BRENDA, the Enzyme Database: 6.3.5.12

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Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (66)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (65)   
Protein sequence (660)   
   UniProt (651)   
   SWISS-PROT (9)   
Protein domain (5)   
   InterPro (5)   
All databases (750)   

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