KEGG ENZYME: 6.5.1.9

ENZYME: 6.5.1.9

Entry

EC 6.5.1.9                  Enzyme

Name

cyclic 2,3-diphosphoglycerate synthase;
cpgS (gene name)

Class

Ligases;
Forming phosphoric-ester bonds;
Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

Sysname

(2R)-2,3-bisphosphoglycerate ligase (cyclizing)

Reaction(IUBMB)

ATP + 2,3-diphospho-D-glycerate = ADP + phosphate + cyclic 2,3-bisphosphoglycerate [RN:R03298]

Reaction(KEGG)

R03298

Substrate

ATP [CPD:C00002];
2,3-diphospho-D-glycerate [CPD:C01159]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
cyclic 2,3-bisphosphoglycerate [CPD:C06189]

Comment

The enzyme is present in a number of methanogenic archaeal genera that accumulate cyclic 2,3-bisphosphoglycerate as a thermoprotectant. Activity is stimulated by potassium ions.

History

EC 6.5.1.9 created 2020

Orthology

K05716

cyclic 2,3-diphosphoglycerate synthase

Genes

SRIM:

CP984_00235

RXY:

Rxyl_1657

RRD:	RradSPS_1599

RUB:	GBA63_11675

RMAR:

GBA65_09400

MTH:

MTH_223

MMG:	MTBMA_c06720

MWO:	MWSIV6_0635(cpgS)

MTEE:

MTTB_08650

METC:

MTCT_0185

METE:

tca_00203(cpgS)

METZ:

METMT2_0667

METK:

FVF72_01190

MTHM:

FZP57_03020

METJ:

FZP68_08055

MST:

Msp_0129

METB:

AW729_06490

MEIS:

PXD04_04455

MRU:

mru_1017

MSI:

Msm_0091

MEB:

Abm4_0688

MMIL:

sm9_0977(cpgS)

MEYE:

TL18_05485

MOL:

YLM1_0561

MARO:

MarbSA_04390

METV:

K4897_00875

MEL:	Metbo_1369

MEW:	MSWAN_0900

METH:

MBMB1_1062(cpgS)

MFC:

BRM9_1264

MFI:	DSM1535_1947(cpgS)

MCUB:

MCBB_0929(cpgS)

MSUB:

BK009_02895

METN:

BK008_10615

METT:

CIT01_09550

METO:

CIT02_02095

MEME:

HYG87_09925

MFEG:

GCM10025860_20840

MFV:

Mfer_0077

MKA:

MK0505

PFU:

PF0079

PFI:

PFC_07805

PHO:	PH0150(PH0150)

PAB:

PAB2252

PYN:

PNA2_0686

PYA:	PYCH_14400

PYS:

Py04_0158

TKO:

TK1039

TON:

TON_0743

TGA:	TGAM_0725(cdpgs)

TSI:

TSIB_0160

TBA:	TERMP_00452

THE:

GQS_01210

THA:

TAM4_882

THM:

CL1_1940

TLT:

OCC_11502

TNU:

BD01_0984

TEU:

TEU_10715

TGY:	X802_06785

THV:	ADU37_CDS00770

TCH:	CHITON_0181

TPEP:

A0127_10020

TPIE:

A7C91_09860

TGG:	A3K92_03145

TCE:	A3L02_08275

TBS:	A3L01_04480

THH:	CDI07_04395

TSL:	A3L11_08580

TTD:	A3L14_06430

TPRF:

A3L09_05015

TRL:	A3L10_02095

TPAF:

A3L08_07430

THY:	A3L12_07815

TIC:	FH039_08735

TCQ:	TIRI35C_1153(cpgS)

THEM:

FPV09_00945

THEI:

K1720_03865

PPAC:

PAP_07615

» show all

Reference

1 [PMID:2226838]

Authors

Lehmacher A, Vogt AB, Hensel R

Title

Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus.

Journal

FEBS Lett 272:94-8 (1990)
DOI:10.1016/0014-5793(90)80456-s

Reference

2 [PMID:9811660]

Authors

Matussek K, Moritz P, Brunner N, Eckerskorn C, Hensel R.

Title

Cloning, sequencing, and expression of the gene encoding cyclic 2, 3-diphosphoglycerate synthetase, the key enzyme of cyclic 2, 3-diphosphoglycerate metabolism in Methanothermus fervidus.

Journal

J Bacteriol 180:5997-6004 (1998)
DOI:10.1128/JB.180.22.5997-6004.1998

Sequence

[mfv:Mfer_0077]

Other DBs

ExplorEnz - The Enzyme Database:

6.5.1.9

IUBMB Enzyme Nomenclature:

6.5.1.9

ExPASy - ENZYME nomenclature database:

6.5.1.9

BRENDA, the Enzyme Database:

6.5.1.9

DBGET integrated database retrieval system