KEGG   ENZYME: 6.7.1.2
Entry
EC 6.7.1.2                  Enzyme                                 
Name
3-aminoavenalumate diazotase;
avaA6 (gene name)
Class
Ligases;
Forming nitrogen-nitrogen bonds;
Forming diazo bonds
Sysname
3-aminoavenalumate:nitrite ligase (AMP-forming)
Reaction(IUBMB)
ATP + 3-aminoavenalumate + nitrite = AMP + diphosphate + 3-diazoavenalumate + H2O [RN:R13241]
Reaction(KEGG)
R13241
Substrate
ATP [CPD:C00002];
3-aminoavenalumate [CPD:C22849];
nitrite [CPD:C00088]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
3-diazoavenalumate [CPD:C22850];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacterium Streptomyces sp. RI-77, participates in the biosynthesis of avenalumate, a phenolic acid originally described from oat (Avena sativa). It can also act on 3-aminocoumarate and 3-amino-4-hydroxybenzoate with lower activity.
History
EC 6.7.1.2 created 2023
Orthology
K27292  3-aminoavenalumate diazotase
Genes
XBO: XBJ1_0408
XBV: XBW1_4371
LAB: LA76x_0605
LAQ: GLA29479_2679
TVD: SG34_003835
MTHD: A3224_01590
MII: BTJ40_01835
CRZ: D1345_00195 D1345_21905
CHAE: CH06BL_00380
BGL: bglu_2g11550
BGU: KS03_4768
BGP: BGL_2c14150
BPLA: bpln_2g14910
AFQ: AFA_06570
AAQU: D3M96_08300
PBH: AAW51_0202 AAW51_4167
MANC: IV454_17580
LEJ: ETW24_22640
LEV: ETW23_23405
SUR: STAUR_3230
CFUS: CYFUS_006416
MYE: AB431_04555
MDX: BTO20_27400
MRH: MycrhN_2390
MCRO: MI149_04835
SFI: SFUL_6231
SANL: KZO11_09780
SGRF: SGFS_087180
SCB: SCAB_2041 SCAB_69801
SRC: M271_02930
SBH: SBI_01611
SALS: SLNWT_4913
SLD: T261_7436
SCZ: ABE83_34465
SPAV: Spa2297_26620
SLS: SLINC_4422 SLINC_6771
SPLU: LK06_027070 LK06_031620
SALJ: SMD11_5959
SFK: KY5_6717
SQZ: FQU76_11635
SKA: CP970_07060
SRK: FGW37_03275
SSPO: DDQ41_19525
SCAV: CVT27_00055
SSEO: D0Z67_01865
SBY: H7H31_03505
SPHV: F9278_09795 F9278_45670
STSU: B7R87_11280
SFEU: IM697_30765
SACT: DMT42_00885
SLF: JEQ17_24430
SDEC: L3078_11340
SAKB: K1J60_34200 K1J60_43975
SCAE: IHE65_34305
SANT: QR300_02470
SJN: RI060_03930
SKG: KJK29_02980
SCOA: QU709_20180 QU709_24635
STRZ: OYE22_03375
KSK: KSE_60560 KSE_65100 KSE_67360
KIS: HUT16_30880 HUT16_31090 HUT16_31800
STRH: GXP74_15505 GXP74_26100 GXP74_28285
ABRY: NYE86_02890
CXIE: NP048_18825
KFL: Kfla_6068
KQI: F1D05_15015
KSL: OG809_05935
NAKE: KGD83_15195
FRE: Franean1_2417
SACG: FDZ84_06780 FDZ84_35405
SSYI: EKG83_30980
KAL: KALB_2256
KUT: JJ691_50940
KPHY: AOZ06_26385
ACTU: Actkin_05214(fadD_2)
UME: RM788_07345
STP: Strop_2492
SAQ: Sare_1054 Sare_2675
MAU: Micau_3484 Micau_3705
MIL: ML5_4694 ML5_4907
MICB: MicB006_2539 MicB006_2804
MTUA: CSH63_07625
MICH: FJK98_09355 FJK98_14020 FJK98_16430
MTEM: GCE86_13415
MCAB: HXZ27_18200
MSAG: GCM10017556_53760
MCHL: PVK74_07665 PVK74_08945
MFEU: H1D33_23005 H1D33_24565
MHAW: RMN56_24440
ASIC: Q0Z83_003620
PFLA: Pflav_007520
PSUU: Psuf_064550
CATI: CS0771_56150 CS0771_77150
DVC: Dvina_13785 Dvina_29165 Dvina_38305
DFU: Dfulv_12425
DAUR: Daura_12920
DMAT: Dmats_13320 Dmats_24405 Dmats_33280
CAI: Caci_3262
MPRO: BJP34_11745
NJA: NSJP_3766
 » show all
Reference
1  [PMID:36115045]
  Authors
Kawai S, Hagihara R, Shin-Ya K, Katsuyama Y, Ohnishi Y.
  Title
Bacterial Avenalumic Acid Biosynthesis Includes Substitution of an Aromatic Amino Group for Hydride by Nitrous Acid Dependent Diazotization.
  Journal
Angew Chem Int Ed Engl 61:e202211728 (2022)
DOI:10.1002/anie.202211728
  Sequence
[ag:BDI54813]
Other DBs
ExplorEnz - The Enzyme Database: 6.7.1.2
IUBMB Enzyme Nomenclature: 6.7.1.2
ExPASy - ENZYME nomenclature database: 6.7.1.2
BRENDA, the Enzyme Database: 6.7.1.2

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Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (179)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (129)   
   KEGG MGENES (49)   
All databases (187)   

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