KEGG ENZYME: 7.2.2.22

ENZYME: 7.2.2.22

Entry

EC 7.2.2.22                 Enzyme

Name

P-type Mn2+ transporter;
Mn(II)-translocating P-type ATPase;
Mn2+-exporting ATPase;
P1B-type ATPase (ambiguous);
ctpC (gene name)

Class

Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate

Sysname

ATP phosphohydrolase (P-type, Mn2+-exporting)

Reaction(IUBMB)

ATP + H2O + Mn2+[side 1] = ADP + phosphate + Mn2+[side 2]

Substrate

ATP [CPD:C00002];
H2O [CPD:C00001];
Mn2+[side 1]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
Mn2+[side 2]

Comment

A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme, detected in mycobacteria, is a high affinity slow turnover ATPase exporting Mn2+.

History

EC 7.2.2.22 created 2021

Orthology

K12950

manganese-transporting P-type ATPase C

Genes

PAQT:

E8L99_09190(cadA)

DTI:	Desti_4193

MRM:	A7982_04415 A7982_04417

BWH:	A9C19_08945

BMQ:	BMQ_pBM40023(cadA)

BMD:

BMD_1817

BMH:	BMWSH_3439

POF:	GS400_05675

NNV:	QNH39_23810

MSEM:

GMB29_10905(cadA)

CBN:

CbC4_1616

CKL:	CKL_1140 CKL_2225

CKR:	CKR_1038 CKR_1959

CCB:	Clocel_3930

CPAS:

Clopa_0928

CPAT:

CLPA_c07980(ctpC)

CPAE:

CPAST_c07980(ctpC)

CSB:	CLSA_c33970(ctpC)

CACE:

CACET_c29480(ctpC) CACET_c29510

CFM:	BJL90_00215

SARJ:

HH195_05035

OCW:	OW730_15215

PETR:

QKW49_07665

DRU:	Desru_0231 Desru_0880 Desru_1040

FWA:	DCMF_17155

AACX:

DEACI_1113

HCV:	FTV88_2286(copB)

GFE:	Gferi_11795 Gferi_18770

PHX:	KGNDJEFE_02142(ctpC)

THYR:

P4S50_16335

IBR:	NQ514_04360

TXY:	Thexy_0562

TSH:

Tsac_1291

BACG:

D2962_00630

MED:

MELS_1467

MHW:	ACT01_07520

MEG:	DKB62_02965

MMAX:

LCQ47_03140

SSG:	Selsp_0562

SRI:	SELR_02390(ctpC)

SELE:

ADJ74_03105

SELO:

AXE86_07215

SELT:

BCS37_09980

SDIA:

QU667_09995

MFUN:

GXM21_08460

PUF:

UFO1_2602

PFT:

JBW_01284

STED:

SPTER_38010(ctpC_1) SPTER_43450(ctpC_2)

MTU:	Rv3270(ctpC)

MTV:

RVBD_3270

MTC:

MT3370

MRA:	MRA_3311(ctpC)

MTF:	TBFG_13299

MTB:	TBMG_03318

MTK:	TBSG_03341

MTZ:	TBXG_003298

MTG:	MRGA327_20135

MTE:	CCDC5079_3018

MTUR:

CFBS_3461(ctpC)

MTL:	CCDC5180_2980

MTO:	MTCTRI2_3337(ctpC)

MTD:	UDA_3270(ctpC)

MTN:	ERDMAN_3586(ctpC)

MTJ:	J112_17580

MTUB:

MT7199_3312

MTUE:

J114_17540

MTX:	M943_16900

MTUL:

TBHG_03206

MTUT:

HKBT1_3448(ctpC)

MTUU:

HKBT2_3455(ctpC)

MTQ:	HKBS1_3458(ctpC)

MBO:	BQ2027_MB3298(ctpC)

MBB:	BCG_3299(ctpC)

MBT:	JTY_3295(ctpC)

MBM:	BCGMEX_3297(ctpC)

MBK:	K60_034000

MBX:

BCGT_3138

MAF:	MAF_32810(ctpC)

MMIC:

RN08_3606

MCE:	MCAN_32891(ctpC)

MCQ:	BN44_70057(ctpC)

MCV:	BN43_60281(ctpC)

MCX:	BN42_41321(ctpC)

MCZ:	BN45_60302(ctpC)

MORY:

MO_003416(ctpC)

MLE:	ML0747(ctpC)

MLB:	MLBr00747(ctpC)

MPA:	MAP_3384(ctpC)

MAO:

MAP4_0398

MAVI:

RC58_01900

MAVU:

RE97_01910

MAV:	MAV_4235(cadA)

MIT:

OCO_40930

MIA:	OCU_23250 OCU_40840

MID:	MIP_04141 MIP_06163 MIP_06567

MYO:	OEM_27760 OEM_32830 OEM_41190

MCHI:

AN480_13080 AN480_17385 AN480_21490

MIR:

OCQ_42200

MMAL:

CKJ54_19525

MLP:

MLM_3393

MMAN:

MMAN_28980(ctpC)

MSA:	Mycsm_02045

MUL:	MUL_2616(ctpC)

MMI:	MMAR_1271(ctpC) MMAR_2147

MMAE:

MMARE11_12370(ctpC)

MLI:	MULP_01432(ctpC)

MPSE:

MPSD_14490(ctpC)

MSHO:

MSHO_60390(ctpC)

MMM:	W7S_14190 W7S_20435 W7S_21845

MKN:	MKAN_21145

MYV:	G155_26670

MHAD:

B586_17545

MSHG:

MSG_01170(ctpC)

MFJ:	MFLOJ_22170(ctpC)

MSTO:

MSTO_25890(ctpC)

MSIM:

MSIM_13180(ctpC)

MSAK:

MSAS_48230(ctpC)

MLW:	MJO58_06170(ctpC)

MXE:	MYXE_22660(ctpC_1) MYXE_37180(ctpC_2)

MNV:	MNVI_28090(ctpC)

MPAG:

C0J29_07085

MNM:	MNVM_30480(ctpC)

MGOR:

H0P51_06305(ctpC)

MCOO:

MCOO_44550(ctpC)

MBAI:

MB901379_01162(ctpV_1)

MSEO:

MSEO_51030(ctpC)

MHEK:

JMUB5695_03663(ctpC_2)

MLJ:	MLAC_04400(ctpC)

MBRD:

MBRA_03700(ctpC)

MSHJ:

MSHI_25000(ctpC)

MMAM:

K3U93_05720(ctpC)

MSPG:

F6B93_05435(ctpC)

MOT:	LTS72_19025(ctpC)

MLM:	MLPF_1182(ctpC)

MPAA:

MKK62_18665(ctpC)

MMEH:

M5I08_09010(ctpC)

MKY:	IWGMT90018_13100(ctpC_1) IWGMT90018_25560(ctpC_2) IWGMT90018_46350(ctpC_3)

MWU:	PT015_23785(ctpC)

MSM:	MSMEG_6058

MSG:	MSMEI_5898(ctpC)

MSB:	LJ00_29955

MSN:	LI99_29960

MSH:	LI98_29965

MNE:	D174_24795

MYN:	MyAD_24330

MFT:	XA26_54000

MLL:	B1R94_05995

MCHT:

MCHIJ_39410

MAUU:

NCTC10437_05089(ctpC)

MMAG:

MMAD_12050

MTY:	MTOK_21820

MANY:

MANY_27710(ctpC)

MAUB:

MAUB_27640

MPOF:

MPOR_54240

MPHU:

MPHO_53450

MMAT:

MMAGJ_33550

MFG:	K6L26_05130

MSEI:

MSEDJ_58050

MGO:	AFA91_10485

MSEN:

K3U95_25770

MGRO:

FZ046_03005

MKR:	MKOR_20300(ctpC)

MPAK:

MIU77_14020(ctpC)

MCHE:

BB28_15955

MIZ:	BAB75_13720

MSTE:

MSTE_03129

MSAL:

DSM43276_02937(ctpV)

MJD:	JDM601_3021(ctpC)

MTER:

4434518_03007(ctpC)

MMIN:

MMIN_07520(ctpC)

MHIB:

MHIB_24640(ctpC)

MHER:

K3U94_17100(ctpC)

MVM:	MJO54_04605(ctpC) MJO54_17105(ctpC)

ROP:

ROP_04370

RHB:

NY08_3578

RFA:	A3L23_01725(ctpC)

RHS:	A3Q41_01637(ctpC)

RHU:	A3Q40_02442(ctpC)

RTM:	G4H71_00160

ROZ:	CBI38_04090

RHOP:

D8W71_17655

WHR:	OG579_20095

GPO:	GPOL_c34470

GTA:	BCM27_24630

GHN:	MVF96_23290

TSM:	ASU32_08625

TPUL:

TPB0596_30020(ctpC)

SLD:

T261_0937

SLK:	SLUN_02380

STIR:

DDW44_06190

SRK:	FGW37_01570

SSPO:

DDQ41_05840

SDW:	K7C20_29645

NML:

Namu_3854

NAK:	EH165_13285

KRA:

Krad_0290

PSEA:

WY02_04240

PSEQ:

AD006_16535

PECQ:

AD017_24370

PHH:	AFB00_28605

PAUT:

Pdca_30780 Pdca_69050(ctpC)

PPEL:

H6H00_22165

KUT:	JJ691_21940

ACTY:

OG774_28985

SLR:	L21SP2_0677

FNU:

FN1190

FNC:	HMPREF0946_00624

FNT:	HMPREF0405_00614

FUS:	HMPREF0409_00895

FNE:	FSDG_00268

FHW:	RN87_09040

FPD:	CTM68_08675

FVA:	FV113G1_30860

FMO:	C4N19_05325

FGO:	C4N16_02980

FNF:	BSQ88_08420

FPEI:

C4N17_01770

FCI:	I6I83_05595

FPOL:

ERS445057_01001(copA_2)

LBA:

Lebu_2040

LEO:	AMK43_05490

LEQ:	BCB68_02930

LHF:	JCM16775_0276

LSZ:	JCM16776_1681

LHG:	JMUB5056_0336

LTE:	JMUB4039_2121

LWD:	JCM16777_0351

LGO:	JCM16774_1333

» show all

Reference

1 [PMID:23482562]

Authors

Padilla-Benavides T, Long JE, Raimunda D, Sassetti CM, Arguello JM

Title

A novel P(1B)-type Mn2+-transporting ATPase is required for secreted protein metallation in mycobacteria.

Journal

J Biol Chem 288:11334-47 (2013)
DOI:10.1074/jbc.M112.448175

Sequence

[mtu:Rv3270]

Other DBs

ExplorEnz - The Enzyme Database:

7.2.2.22

IUBMB Enzyme Nomenclature:

7.2.2.22

ExPASy - ENZYME nomenclature database:

7.2.2.22

BRENDA, the Enzyme Database:

7.2.2.22

All links

Gene (2504)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (251)   
   KEGG MGENES (2252)   
Protein sequence (8)   
   UniProt (4)   
   SWISS-PROT (4)   
Protein domain (10)   
   InterPro (10)   
All databases (2522)   

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