KEGG   ENZYME: 7.2.2.3
Entry
EC 7.2.2.3                  Enzyme                                 
Name
P-type Na+ transporter;
Na+-exporting ATPase (ambiguous);
ENA1 (gene name);
ENA2 (gene name);
ENA5 (gene name);
sodium transport ATPase (ambiguous);
sodium-translocating P-type ATPase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
Sysname
ATP phosphohydrolase (P-type, Na+-exporting)
Reaction(IUBMB)
ATP + H2O + Na+[side 1] = ADP + phosphate + Na+[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+[side 2]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed. Some forms can also export Li+ ions. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.4, ABC-type Na+ transporter.
History
EC 7.2.2.3 created 2000 as EC 3.6.3.7, modified 2001, transferred 20018 to EC 7.2.2.3
Orthology
K01536  P-type Na+/K+ transporter
Genes
AJM: 119047126
PPP: 112273674 112276792 112295107
SCE: YDR038C(ENA5) YDR039C(ENA2) YDR040C(ENA1)
SEUB: DI49_0236
SPAO: SPAR_D02580
AGO: AGOS_AGL097C
ERC: Ecym_4150
KLA: KLLA0_E14587g KLLA0_F20658g
KMX: KLMA_40202(ENA5)
LTH: KLTH0F08030g
VPO: Kpol_1052p20
ZRO: ZYRO0E06930g
CGR: CAGL0K12034g
NCS: NCAS_0A10620(NCAS0A10620)
NDI: NDAI_0A05680(NDAI0A05680)
TPF: TPHA_0A04000(TPHA0A04000) TPHA_0A04010(TPHA0A04010)
TBL: TBLA_0E02620(TBLA0E02620)
TGB: HG536_0C03450
TDL: TDEL_0D03490(TDEL0D03490) TDEL_0G04940(TDEL0G04940)
KAF: KAFR_0A01060(KAFR0A01060)
KNG: KNAG_0H01200(KNAG0H01200)
ZMK: HG535_0A03620
PPA: PAS_chr1-1_0428
DHA: DEHA2C02552g DEHA2G09108g
PIC: PICST_73371(ENA5) PICST_74899(ENA2)
PGU: PGUG_02728
SPAA: SPAPADRAFT_158103(ENA1) SPAPADRAFT_67476(ENA1.1)
LEL: PVL30_001447(ENA2)
CAL: CAALFM_C100390WA(ENA2) CAALFM_C702910WA(ENA21)
CTP: CTRG_04307 CTRG_04987 CTRG_04991
COT: CORT_0B06970 CORT_0H02780
CDU: CD36_00320 CD36_72570
CTEN: CANTEDRAFT_119074 CANTEDRAFT_135950
YLI: YALI0A01023g YALI0E19338g
CLU: CLUG_00309
CLUS: A9F13_08g01177
CAUR: CJI96_0001355 CJI96_0002847
SLB: AWJ20_3228(ENA5)
PKZ: C5L36_0A11250 C5L36_0A11260
BNN: FOA43_004483
BBRX: BRETT_002302
OPA: HPODL_03387
NCR: NCU05046(ena-1) NCU07966 NCU08147(ph7)
NTE: NEUTE1DRAFT144929(NEUTE1DRAFT_144929) NEUTE1DRAFT86499(NEUTE1DRAFT_86499) NEUTE1DRAFT88512(NEUTE1DRAFT_88512)
SMP: SMAC_03602 SMAC_07599 SMAC_08578
PAN: PODANSg1069 PODANSg2243 PODANSg445 PODANSg4612
PBEL: QC761_0082220(ENA2) QC761_301600(cta3) QC761_502680 QC761_704300
PPSD: QC762_0049090(cta3) QC762_502680 QC762_507060(ENA2) QC762_704300
PPSP: QC763_0048580(cta3) QC763_502680 QC763_507060(ENA2) QC763_704300
PPSA: QC764_0048190(cta3) QC764_502680 QC764_507060(ENA2) QC764_704300
MTM: MYCTH_112905 MYCTH_2144990 MYCTH_2305754
CTHR: CTHT_0020740 CTHT_0020970 CTHT_0030720 CTHT_0049790
MGR: MGG_02074 MGG_05078 MGG_10730 MGG_13279
PPEI: PpBr36_00030 PpBr36_02715 PpBr36_03455 PpBr36_10562
PGRI: PgNI_01219 PgNI_02289 PgNI_05102 PgNI_05257
TMN: UCRPA7_3618 UCRPA7_4253 UCRPA7_5207
SSCK: SPSK_02183
FGR: FGSG_02677 FGSG_04245 FGSG_04919 FGSG_04995 FGSG_08985
FPU: FPSE_00384 FPSE_03963 FPSE_07116 FPSE_08743 FPSE_12290
FPOA: FPOAC1_002805 FPOAC1_006702 FPOAC1_007791 FPOAC1_007890 FPOAC1_012750
FVN: FVRRES_03121 FVRRES_07323 FVRRES_08325 FVRRES_08426 FVRRES_13866
FVR: FVEG_03567 FVEG_06648 FVEG_06769 FVEG_10435 FVEG_16502
FOX: FOXG_05702 FOXG_06571 FOXG_06575 FOXG_06687 FOXG_06691 FOXG_07251 FOXG_07255 FOXG_09046 FOXG_10377 FOXG_11383 FOXG_20003
NHE: NECHADRAFT_100814 NECHADRAFT_35238 NECHADRAFT_43112 NECHADRAFT_62632 NECHADRAFT_65962 NECHADRAFT_70849
FFC: NCS54_00368700 NCS54_00470700 NCS54_00817400 NCS54_00985900 NCS54_01003600 NCS54_01011700
FKR: NCS57_00374200 NCS57_00476700 NCS57_00860700 NCS57_00997800 NCS57_01005600 NCS57_01479500
FMU: J7337_003585 J7337_005363 J7337_009304 J7337_009429 J7337_011711
TRE: TRIREDRAFT_122972 TRIREDRAFT_81430 TRIREDRAFT_81536
TRR: M419DRAFT_139005 M419DRAFT_142734 M419DRAFT_83372
MAW: MAC_01178 MAC_06648 MAC_07338 MAC_07846
MAJ: MAA_04816 MAA_05556 MAA_08450 MAA_09724
PCHM: VFPPC_01952 VFPPC_03177 VFPPC_06403 VFPPC_07607 VFPPC_12075
CMT: CCM_01629 CCM_02511 CCM_04844 CCM_08837
AMUS: LMH87_003463 LMH87_008662 LMH87_009983 LMH87_010364
PLJ: VFPFJ_01534 VFPFJ_04629 VFPFJ_06044 VFPFJ_06500 VFPFJ_09351 VFPFJ_10780
PTKZ: JDV02_002348(cta3) JDV02_002947 JDV02_003226 JDV02_004260 JDV02_005746(ENA2)
VAL: VDBG_02460 VDBG_02955 VDBG_03550 VDBG_06477 VDBG_07580
VDA: VDAG_02935 VDAG_03863 VDAG_05014 VDAG_09301 VDAG_09836
CFJ: CFIO01_05232 CFIO01_06516 CFIO01_08176 CFIO01_08329 CFIO01_10630
CLUP: CLUP02_07144 CLUP02_07238 CLUP02_11487 CLUP02_13015 CLUP02_15390
CHIG: CH63R_00134 CH63R_03608 CH63R_03689 CH63R_05000 CH63R_11099
SAPO: SAPIO_CDS10188 SAPIO_CDS10460 SAPIO_CDS2534 SAPIO_CDS5079 SAPIO_CDS5332
ELA: UCREL1_4203 UCREL1_663 UCREL1_8093
PFY: PFICI_00118 PFICI_01488 PFICI_15126 PFICI_15176
SSL: SS1G_06551 SS1G_10477
BFU: BCIN_11g03050 BCIN_14g04570 BCIN_15g05670
MBE: MBM_01457 MBM_03723
PSCO: LY89DRAFT_643844
GLZ: GLAREA_04743 GLAREA_09795 GLAREA_11186
ANI: ANIA_01628 ANIA_06642 ANIA_10982
AFM: AFUA_2G01320 AFUA_4G09440 AFUA_6G03690
ACT: ACLA_094630 ACLA_096890
NFI: NFIA_033620 NFIA_050200 NFIA_106580
AOR: AO090009000591 AO090023000590 AO090701000406
ANG: An09g00690 An15g01830
AFV: AFLA_004921 AFLA_006936 AFLA_010781
ALUC: AKAW2_40067A AKAW2_60514A
ACHE: ACHE_10071S ACHE_50116S
APUU: APUU_10609A APUU_20139A APUU_21503S APUU_60955A APUU_80232S
PCS: N7525_006382 N7525_008997 N7525_009719 N7525_010333
PDP: PDIP_16990
POU: POX_b03294 POX_f07635
TMF: EYB26_005233
TRG: TRUGW13939_02730 TRUGW13939_08840
CIM: CIMG_00162 CIMG_03108 CIMG_12859(CIMG00571)
CPW: CPC735_010390 CPC735_056720 CPC735_059820
URE: UREG_00257 UREG_00592 UREG_02849
PBL: PAAG_05329 PAAG_11749(PAAG_03790) PAAG_12330(PAAG_07077)
PBN: PADG_01602 PADG_03294 PADG_06672
ABE: ARB_02138 ARB_02320 ARB_03734 ARB_05763
TVE: TRV_01501 TRV_04479 TRV_05052 TRV_06589
AJE: HCAG_02264 HCAG_06089 HCAG_07215
BGH: BDBG_00747 BDBG_07515 BDBG_16537
PNO: SNOG_09636 SNOG_11155 SNOG_15715
PTE: PTT_09305 PTT_12722 PTT_14661
BZE: COCCADRAFT_3848 COCCADRAFT_538 COCCADRAFT_6187
BSC: COCSADRAFT_182008 COCSADRAFT_188039 COCSADRAFT_25174
BOR: COCMIDRAFT_24070 COCMIDRAFT_4198 COCMIDRAFT_88295
AALT: CC77DRAFT_1015658 CC77DRAFT_1018468 CC77DRAFT_742985
ARAB: EKO05_0000411 EKO05_0006677 EKO05_0010145
ZTR: MYCGRDRAFT_100176 MYCGRDRAFT_74566 MYCGRDRAFT_84460
PFJ: MYCFIDRAFT_149581 MYCFIDRAFT_59513
FFU: CLAFUR5_02271 CLAFUR5_07559
CBET: CB0940_00957 CB0940_05844 CB0940_10695
BCOM: BAUCODRAFT_81255
NPA: UCRNP2_1716 UCRNP2_2244 UCRNP2_6680
TML: GSTUM_00000681001 GSTUM_00005356001 GSTUM_00008991001
SPO: SPBC839.06(cta3)
SOM: SOMG_02315(cta3)
CNE: CNA05130
CNB: CNBA4950
CNG: CNAG_00531
CGI: CGB_A5410C
CDEU: CNBG_1386
TASA: A1Q1_03170 A1Q1_03630
CCAC: CcaHIS019_0404190(CcaverHIS019_0404190) CcaHIS019_0705670(CcaverHIS019_0705670)
ADL: AURDEDRAFT_109639 AURDEDRAFT_147307 AURDEDRAFT_99896
RSX: RhiXN_04973 RhiXN_07292
CCI: CC1G_00228 CC1G_07450
PCUB: JR316_0005025
MRR: Moror_11414 Moror_2390
MORE: E1B28_003858 E1B28_012936
SCM: SCHCO_02616602(SCHCODRAFT_02616602)
WSE: WALSEDRAFT_53229(cta3)
WIC: J056_000751 J056_002156
UMA: UMAG_00204 UMAG_15043
PFP: PFL1_00514 PFL1_02641 PFL1_04558
SGRA: EX895_000420 EX895_003824
MGL: MGL_3722
MSYM: MSY001_0060
ACAN: ACA1_065450
TBR: Tb09.244.2570
TBG: TbgDal_IX9590
TCR: 506241.70 510769.120
LMA: LMJF_35_2080
LIF: LINJ_35_2080
LDO: LDBPK_352080
LMI: LMXM_34_2080
LBZ: LBRM_34_1990
LPAN: LPMP_341910
NGR: NAEGRDRAFT_202
 » show all
Reference
1  [PMID:7664728]
  Authors
Wieland J, Nitsche AM, Strayle J, Steiner H, Rudolph HK
  Title
The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane.
  Journal
EMBO J 14:3870-82 (1995)
DOI:10.1002/j.1460-2075.1995.tb00059.x
  Sequence
[sce:YDR040C YDR039C]
Reference
2  [PMID:9224683]
  Authors
Catty P, de Kerchove d'Exaerde A, Goffeau A.
  Title
The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases.
  Journal
FEBS Lett 409:325-32 (1997)
DOI:10.1016/S0014-5793(97)00446-8
  Sequence
[sce:YDR040C YDR039C YDR038C]
Reference
3  [PMID:9315618]
  Authors
Benito B, Quintero FJ, Rodriguez-Navarro A
  Title
Overexpression of the sodium ATPase of Saccharomyces cerevisiae: conditions for phosphorylation from ATP and Pi.
  Journal
Biochim Biophys Acta 1328:214-26 (1997)
DOI:10.1016/s0005-2736(97)00098-9
  Sequence
[sce:YDR040C]
Reference
4  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
DOI:10.1016/s0065-2911(08)60130-7
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.3
IUBMB Enzyme Nomenclature: 7.2.2.3
ExPASy - ENZYME nomenclature database: 7.2.2.3
BRENDA, the Enzyme Database: 7.2.2.3

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Gene (1011)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (411)   
   KEGG MGENES (57)   
   RefGene (542)   
Protein sequence (3133)   
   UniProt (3089)   
   SWISS-PROT (10)   
   RefSeq(pep) (34)   
DNA sequence (105)   
   RefSeq(nuc) (62)   
   GenBank (22)   
   EMBL (21)   
Protein domain (11)   
   InterPro (11)   
All databases (4260)   

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