Entry
Name
carboxybiotin decarboxylase;
MadB;
carboxybiotin protein decarboxylase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to decarboxylation
BRITE hierarchy
Sysname
carboxybiotinyl-[protein] carboxy-lyase
Reaction(IUBMB)
a carboxybiotinyl-[protein] + n Na+[side 1] + H+[side 2] = CO2 + a biotinyl-[protein] + n Na+[side 2] (n = 1--2) [RN:
R09509 ]
Reaction(KEGG)
Substrate
carboxybiotinyl-[protein] [CPD:
C18047 ];
Na+[side 1];
H+[side 2]
Product
CO2 [CPD:
C00011 ];
biotinyl-[protein] [CPD:
C18046 ];
Na+[side 2] (n = 1--2)
Comment
The integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra is a component of the multienzyme complex EC
4.1.1.89 , biotin-dependent malonate decarboxylase. The free energy of the decarboxylation reaction is used to pump Na+ out of the cell. The enzyme is a member of the Na+-translocating decarboxylase family, other members of which include EC
7.2.4.2 [oxaloacetate decarboxylase (Na+ extruding)] and EC
7.2.4.3 [(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)] [2].
History
EC 7.2.4.1 created 2008 as EC 4.3.99.2, transferred 2018 to EC 7.2.4.1
Orthology
K20509 carboxybiotin decarboxylase
Genes
EFE : EFER_0028(oadB) EFER_3127
STY : STY0063(oadB) STY3531(oadB)
STT : t0056(oadB) t3266(oadB)
SEX : STBHUCCB_34540 STBHUCCB_650
SENT : TY21A_00290 TY21A_16565
STM : STM0054 STM0768(dcoB) STM3351(oadB)
SEO : STM14_0064 STM14_0892(dcoB) STM14_4043(oadB)
SEV : STMMW_00551 STMMW_08201 STMMW_33501
SEY : SL1344_0055 SL1344_0745(dcoB) SL1344_3323(oadB2)
SEM : STMDT12_C00550 STMDT12_C08210 STMDT12_C34090
SEJ : STMUK_0055 STMUK_0773 STMUK_3337(oadB)
SEB : STM474_0057 STM474_0793 STM474_3511(oadB)
SEF : UMN798_0061(oadB2) UMN798_0833(oadB2) UMN798_3643(oadB2)
SETU : STU288_00270 STU288_10575 STU288_16965
SETC : CFSAN001921_00235 CFSAN001921_13185 CFSAN001921_17150
SENR : STMDT2_07461(oadB2) STMDT2_32431
SEND : DT104_00551(oadB2) DT104_07841(dcoB) DT104_33441
SENI : CY43_00265 CY43_04140 CY43_17450
SEEN : SE451236_06280 SE451236_09870 SE451236_22870
SPT : SPA0055(oadB) SPA3218(oadB)
SPQ : SPAB_00065 SPAB_04177
SEI : SPC_0058(oadB) SPC_0764(oadB) SPC_3421(oadB)
SEC : SCH_0048(oadB) SCH_0766(oadB) SCH_3289(oadB)
SEH : SeHA_C0058 SeHA_C0895 SeHA_C3649
SHB : SU5_01440 SU5_03835 SU5_0690
SENH : CFSAN002069_05000 CFSAN002069_08955 CFSAN002069_15415
SEEH : SEEH1578_02855 SEEH1578_09305 SEEH1578_13230
SEE : SNSL254_A0059 SNSL254_A0832 SNSL254_A3614
SENN : SN31241_10340 SN31241_17670 SN31241_44750
SEW : SeSA_A0060 SeSA_A3543
SEA : SeAg_B0061 SeAg_B0804 SeAg_B3542
SENS : Q786_00270 Q786_03725 Q786_16340
SED : SeD_A0059 SeD_A0863 SeD_A3711
SEG : SG0057 SG0746(oadB2) SG3241(oadB3)
SEL : SPUL_0058 SPUL_2208 SPUL_3361
SEGA : SPUCDC_0058 SPUCDC_2194 SPUCDC_3347
SET : SEN0055 SEN0713 SEN3184
SENA : AU38_00270 AU38_03715 AU38_16225
SENO : AU37_00270 AU37_03700 AU37_16425
SENV : AU39_00270 AU39_03705 AU39_16425
SENQ : AU40_00295 AU40_04110 AU40_18275
SENL : IY59_00285 IY59_03765 IY59_16835
SENJ : CFSAN001992_10760 CFSAN001992_16795
SEEC : CFSAN002050_06725 CFSAN002050_10395 CFSAN002050_23725
SEEB : SEEB0189_003105 SEEB0189_019115
SEEP : I137_10035 I137_16045
SENB : BN855_34280(oadB2) BN855_560 BN855_7395
SENE : IA1_00275 IA1_03910 IA1_16235
SENC : SEET0819_00360 SEET0819_07165 SEET0819_10780
SALZ : EOS98_02530 EOS98_15335 EOS98_18970
KPN : KPN_00030(dcoB) KPN_00766 KPN_03636
KPY : KPNIH31_04070 KPNIH31_23170
KPT : VK055_2545(oadB) VK055_3841(oadB2)
KPB : FH42_14155 FH42_20960
KPNK : BN49_0484(oadB_C) BN49_4310(oadB_N)
KPE : KPK_0485(oadB_2) KPK_4719(oadB_1)
KVQ : SP68_12335 SP68_18585
KOY : J415_05815 J415_27115
KOM : HR38_02500 HR38_09335
KOK : KONIH1_04340 KONIH1_26460
KOC : AB185_09830 AB185_31840
KQV : B8P98_02510 B8P98_02670 B8P98_23645 B8P98_25025
KLW : DA718_03355(madB) DA718_24165 DA718_28165
KGR : JJJ10_02620 JJJ10_02990(madB) JJJ10_19380 JJJ10_23665
KPAS : LUW96_03530(madB) LUW96_03930 LUW96_10880
KLC : K7H21_02595 K7H21_03000(madB) K7H21_23795
KLM : BWI76_04415 BWI76_24990 BWI76_25380
PDAG : 4362423_01743(oadB)
ALIG : NCTC10568_01712(oadB)
ASEG : NCTC10977_01471(oadB)
AVT : NCTC3438_00331(oadB)
RPNE : NCTC8284_00504(oadB)
PAET : NCTC13378_01917(oadB)
VCF : IR04_07740 IR04_09350
VCE : Vch1786_I0298 Vch1786_I2864
VCQ : EN18_07340 EN18_19760
VCJ : VCD_001054 VCD_003533
VCO : VC0395_A0086(oadB-1) VC0395_A0319(oadB-2)
VCR : VC395_0568(oadB-1) VC395_0809(oadB-2)
VCM : VCM66_0509(oadB-1) VCM66_0750(oadB-2)
VCX : VAA049_2907 VAA049_3137
VCZ : VAB027_1444 VAB027_3291
VPK : M636_02820 M636_09240
VHR : AL538_01550 AL538_06605
VEJ : VEJY3_13125 VEJY3_17131
LAG : N175_08960 N175_12870
VAU : VANGNB10_cI0455(oadB-1) VANGNB10_cI1186(oadB-2)
VMI : AL543_11900 AL543_13240
VTA : A0111(oadB) B0177(oadB)
VZI : G5S32_08645 G5S32_12130
VPL : SA104470976_01940(oadB) SA104470976_02170(gcdB)
VTI : CEQ48_14790 CEQ48_16075
VMT : QYQ96_09990 QYQ96_11075
PPR : PBPRA2299(T3266) PBPRA3050(T3266)
MSHE : MAALD49_23500(oadB)
SALH : HMF8227_02229(oadB)
TFRI : Thiofri_00821(gcdB)
HSI : BOX17_10305 BOX17_13525
HVN : EI420_03590 EI420_12960
CDIZ : CEDIAZO_02605(oadB_1) CEDIAZO_02824(oadB_2)
BVR : BVIR_2317 BVIR_2319 BVIR_754
RAP : RHOA_2176(gcdB) RHOA_4936(madB)
AZZ : DEW08_20155(madB) DEW08_25355
DEX : HWD60_02260 HWD60_04305
DVN : HQ394_14435 HQ394_17120
CPIN : CPIN18020_1008(oadB)
AELL : AELL_0302(oadB1) AELL_1495(oadB2)
AAQI : AAQM_0230(oadB1) AAQM_1291(oadB2)
ACLO : ACLO_0289(oadB1) ACLO_1340(oadB2)
AVP : AVENP_0292(oadB1) AVENP_1591(oadB2)
ADZ : ADFLV_0302(oadB1) ADFLV_1588(oadB2)
PACO : AACT_0365(oadB1) AACT_1524(oadB2)
HBV : ABIV_1301(oadB1) ABIV_2120(oadB2)
DLM : DPPLL_27290 DPPLL_34210
DBK : DGMP_10870 DGMP_33560
DAT : HRM2_06280(oadB1) HRM2_38530(oadB2) HRM2_38660(oadB3)
DWD : DSCW_41940 DSCW_57850
DML : Dmul_03490(oadB1) Dmul_10450(oadB2) Dmul_25040(gcdB)
DLI : dnl_11270(oadB1) dnl_18400(oadB2)
DEK : DSLASN_36380 DSLASN_36890
SAT : SYN_00115 SYN_01431 SYN_01434
SPZ : M5005_Spy0897 M5005_Spy0903(oadB)
SPYM : M1GAS476_0953 M1GAS476_0959(oadB)
SPYA : A20_0934(gcdB) A20_0940(gcdB)
SPM : spyM18_1129 spyM18_1135
SPG : SpyM3_0825 SpyM3_0831
SPH : MGAS10270_Spy1011 MGAS10270_Spy1017(oadB)
SPI : MGAS10750_Spy1046 MGAS10750_Spy1052(oadB)
SPA : M6_Spy0886 M6_Spy0892
SPB : M28_Spy0870 M28_Spy0876(oadB)
STG : MGAS15252_0895(oadB.1) MGAS15252_0901(oadB.2)
STX : MGAS1882_0890(oadB.1) MGAS1882_0896(oadB.2)
SOZ : Spy49_0926 Spy49_0933
STZ : SPYALAB49_000888 SPYALAB49_000894
SPYH : L897_04440 L897_04470
SPYO : STAB901_05080 STAB901_05110
SMC : SmuNN2025_1006(oadB)
SDS : SDEG_0989(oadB) SDEG_0996
SDG : SDE12394_05525 SDE12394_05560
SDC : SDSE_1018(oadB) SDSE_1025(gcdB)
SMEN : SAMEA4412692_1182(gcdB)
SPSU : NCTC13786_01459(oadB)
SPOC : NCTC10925_01697(oadB)
ESG : EsVE80_15340 EsVE80_22520
ECEC : NCTC12421_00644(gcdB_1) NCTC12421_01656(gcdB_2)
EDS : PML78_09410 PML78_13140
EMS : P3T75_01645 P3T75_05625
FCT : NRE15_01645 NRE15_09850
JPO : G7058_02250 G7058_04020
GAD : K8O88_01750 K8O88_04120
DINC : QNK01_10385 QNK01_10390
CCOH : SAMEA4530647_0549(gcdB)
CLOS : DMR38_02885 DMR38_13080
CTHD : CDO33_08565 CDO33_09875
HHJ : NQ487_00040 NQ487_20610 NQ487_28640
OCW : OW730_04050 OW730_25875
CSS : Cst_c06330(gcdB) Cst_c12080(oadB)
CSD : Clst_0601(oadB1) Clst_1166(oadB2)
FPRA : CG447_03600 CG447_15010
FDU : GXM22_05330 GXM22_08960
CAML : H6X83_01190 H6X83_05710
CARL : PXC00_01525 PXC00_04155
ACOL : K5I23_02985 K5I23_11675
SVJ : NQ490_02770 NQ490_07440
LASA : L9O85_05205 L9O85_09795
PALM : RBG61_04645 RBG61_08025 RBG61_09675
CAPR : EQM14_07110 EQM14_12270 EQM14_14360
CFEM : HCR03_03975 HCR03_10480 HCR03_18535
AGAT : RWV98_01635 RWV98_06090
INT : RX717_03880 RX717_15125
DOR : Desor_1187 Desor_1193 Desor_1200 Desor_4457
TFR : BR63_01825 BR63_02220 BR63_06355 BR63_17710
FWA : DCMF_05730 DCMF_06310 DCMF_23020 DCMF_26050
DGI : Desgi_0906 Desgi_4606
PROM : QO263_04985 QO263_06155 QO263_07535
BPRS : CK3_10290 CK3_31500
BPRO : PMF13cell1_04189(gcdB)
LACY : A4V08_12185 A4V08_32675
CSCI : HDCHBGLK_03212(gcdB)
CSH : Closa_1327 Closa_2394
CSO : CLS_13260 CLS_16240 CLS_22680
LXA : OW255_11510 OW255_13540 OW255_17230
HSD : SD1D_0451 SD1D_1113(gcdB)
ANR : Ana3638_02755 Ana3638_06875 Ana3638_13390
ACEL : acsn021_26680 acsn021_39950
ACHT : bsdcttw_05230 bsdcttw_07710 bsdcttw_38240
CBOL : CGC65_04080 CGC65_11640
CASP : NQ535_04770 NQ535_11670
WCP : H9Q76_06175 H9Q76_10800
QDO : H9Q78_00450 H9Q78_02750
WHJ : H9Q79_03670 H9Q79_04200
MFOR : NQ534_02980 NQ534_17120
AHB : bsdtb5_16260 bsdtb5_26240
STOM : QU660_00440 QU660_01180 QU660_04955
KIB : RBB56_05105 RBB56_13105 RBB56_16445
CLE : Clole_2003 Clole_2267
CEW : EKH84_12140 EKH84_14020
CBAR : PATL70BA_0283(oadB)
GFE : Gferi_08050 Gferi_16905
PBIF : KXZ80_05960 KXZ80_11085
PSOR : RSJ16_06810 RSJ16_12825
TEM : JW646_05375 JW646_06220
TGC : L0P85_02160 L0P85_03005
TEB : T8CH_0066(gcdB) T8CH_2223(gcdB) T8CH_2665(gcdB)
THYR : P4S50_06110 P4S50_17370
EAC : EAL2_808p06910(gcdB)
FAA : HMPREF0389_01468 HMPREF0389_01641
CMIU : B1H56_03545 B1H56_04835
TTE : TTE0252(OadB) TTE1215(OadB2) TTE1798(OadB3)
TWI : Thewi_0248 Thewi_1760
MAS : Mahau_0038 Mahau_0965
BACG : D2962_04725 D2962_05820 D2962_13050
AFT : BBF96_03160 BBF96_04275 BBF96_05015
KME : H0A61_01400(gcdB_1) H0A61_02557(gcdB_2)
PED : ING2D1G_1321(gcdB1) ING2D1G_1425(gcdB3)
PHAR : NCTC13077_00173(gcdB)
PEQU : O6R05_07360 O6R05_08095
SPOA : EQM13_14010 EQM13_14800
TIS : P3962_09560 P3962_10370
TIZ : RBU61_01830 RBU61_02885
VRM : 44547418_01322(gcdB)
VDN : NCTC11831_00635(gcdB)
DHO : Dia5BBH33_00600 Dia5BBH33_00630 Dia5BBH33_00660 Dia5BBH33_00690 Dia5BBH33_00720 Dia5BBH33_00750 Dia5BBH33_00780 Dia5BBH33_14010
SGBI : P3F81_00175 P3F81_08720
PUF : UFO1_1201 UFO1_3049 UFO1_3270
PFT : JBW_00116 JBW_01387 JBW_01690 JBW_01700
AFN : Acfer_1500 Acfer_1834
PFAC : PFJ30894_00493(madB) PFJ30894_00913(gcdB_1) PFJ30894_00917(gcdB_2)
FCZ : IMF26_03060 IMF26_08625
CHL : Chy400_3298 Chy400_3694
OBG : Verru16b_01940(madB)
ELUT : CKA38_12025 CKA38_13890
OBT : OPIT5_02010 OPIT5_02470
LCRE : Pla8534_41100(gcdB)
SMAM : Mal15_48490(gcdB_1) Mal15_68430(gcdB_2)
SNEP : Enr13x_02230(gcdB_1) Enr13x_12950(gcdB_2)
AMUC : Pan181_09860(gcdB_1) Pan181_30420(gcdB_2)
VBC : C5Q97_04905 C5Q97_07775
TSU : Tresu_0524 Tresu_0886
TBE : Trebr_0618 Trebr_1686
TPHG : FUT81_01900 FUT81_06575
TRC : DYE49_00290 DYE49_07645
BPAA : K7I13_02420 K7I13_06655
SBU : SpiBuddy_0507 SpiBuddy_0560
SGP : SpiGrapes_1395 SpiGrapes_1468
SASS : MUG09_03040 MUG09_03225
SCC : Spico_0318 Spico_1173
TAZ : TREAZ_0935 TREAZ_1848
BHC : JFL75_10335 JFL75_16390 JFL75_19260
BHY : BHWA1_00381 BHWA1_02045(oadB)
BHD : BHYOB78_01095 BHYOB78_05920
BPO : BP951000_0043 BP951000_0991(oadB)
BPJ : B2904_orf1328 B2904_orf368
BPIP : BPP43_02870 BPP43_10120
BIP : Bint_1369 Bint_2655(oadB)
BHP : BHAMNSH16_08780 BHAMNSH16_14015
FGO : C4N16_05270 C4N16_07350
FNF : BSQ88_03985 BSQ88_06965
FPOL : ERS445057_00629(gcdB)
IPO : Ilyop_0300 Ilyop_2723
CPOR : BED41_04310 BED41_12265 BED41_13460
ACO : Amico_0270 Amico_0883 Amico_1549
PPIO : CE91St28_18670 CE91St28_24990
PYY : RAH42_00735 RAH42_08305
ARAM : KAR29_02205 KAR29_05470 KAR29_07025
BTH : BT_1689 BT_1696 BT_4415
BTHO : Btheta7330_01320(gcdB_1) Btheta7330_01328(gcdB_2) Btheta7330_03681(madB)
BFR : BF1137 BF2936 BF3292
BFS : BF9343_1004(mmdB) BF9343_2732 BF9343_3045(mmdB)
BFG : BF638R_1123(mmdB) BF638R_2827 BF638R_3155(mmdB)
BFB : VU15_04915 VU15_12630 VU15_14695
BHL : Bache_1682 Bache_3077
BOA : Bovatus_01771(gcdB_1) Bovatus_01782(gcdB_2) Bovatus_04664(madB)
BCEL : BcellWH2_01306(gcdB_1) BcellWH2_03043(madB) BcellWH2_04425(gcdB_2)
BCAC : CGC64_08450 CGC64_16670 CGC64_16715
BCAE : A4V03_12440 A4V03_12470
BHF : C3V43_01165 C3V43_01470
BIS : DXK01_005930 DXK01_011370 DXK01_021105
BUN : Bun01g_06260 Bun01g_18990 Bun01g_20880
BEG : INE88_00657(gcdB_1) INE88_03141(gcdB_2)
BSTE : K6V31_05750 K6V31_15580
BFE : K6V30_10605 K6V30_21985 K6V30_22020
BNO : K8P02_02425 K8P02_12320 K8P02_12445
BHUM : JXR92_003445 JXR92_008815 JXR92_009590
BFC : BacF7301_11940 BacF7301_23460 BacF7301_23500
BSAL : K6V25_19450 K6V25_19565
BFIN : BFINE_52370 BFINE_52460
BDO : EL88_05385 EL88_05745 EL88_17395
BDH : GV66_10165 GV66_12975 GV66_13655
PCOP : I6J50_10180 I6J50_11595
PCRE : NCTC12858_00696(gcdB)
PCAG : NCTC12856_00113(gcdB)
PBT : ING2E5B_1569 ING2E5B_1570(gcdB) ING2E5B_1666
PMUC : ING2E5A_1041(oadB2-1) ING2E5A_1042(oadB2-2) ING2E5A_1825(oadB)
PET : PEIBARAKI_4870 PEIBARAKI_4871 PEIBARAKI_5826
PSAC : PSM36_0959 PSM36_2144 PSM36_2145(gcdB)
PROJ : KDN43_08205 KDN43_08715 KDN43_08720
PARC : CI960_03915 CI960_19650
PMER : INE87_01413(gcdB_1) INE87_02291(gcdB_2)
PGOL : K6V26_03855 K6V26_08905 K6V26_19910
PJO : LK449_10230 LK449_18140
PFAI : NXY11_02575 NXY11_07440 NXY11_18790
COPR : Cop2CBH44_07690 Cop2CBH44_11990
CFAS : Cfast33896_22690 Cfast33896_24650
PCLR : PC1C4_00080 PC1C4_11330
ACOU : A5CBH24_18300 A5CBH24_21360
ADA : A5CPEGH6_10100 A5CPEGH6_20340
ASEN : NQ519_10885 NQ519_14080
DORI : FH5T_13550 FH5T_18405
DRC : G0Q07_10650 G0Q07_15515
MCOS : GM418_21780 GM418_28165
ASX : CDL62_18120 CDL62_18415
ALKQ : M9189_05330 M9189_05795
FYA : KMW28_11490 KMW28_18105
CLIT : OQ292_13405 OQ292_16750
FAX : FUAX_13750 FUAX_15980
PPSV : PEPS_21680 PEPS_38990
PROC : Ptc2401_01012(gcdB)
CACI : CLOAM1513 CLOAM1771
FPE : Ferpe_1633 Ferpe_1665
FIA : NA23_08075 NA23_08240
FRR : IB67_03230 IB67_03395
MPG : Theba_0477 Theba_2046
MINF : MESINF_1656(gcdB) MESINF_2159(gcdB)
CPO : COPRO5265_0584 COPRO5265_0907
MSCH : N508_000895 N508_001012(gcdB)
» show all
Taxonomy
Reference
Authors
Berg M, Hilbi H, Dimroth P
Title
Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.
Journal
Sequence
Reference
Authors
Dimroth P, Hilbi H
Title
Enzymic and genetic basis for bacterial growth on malonate.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 7.2.4.1
ExPASy - ENZYME nomenclature database: 7.2.4.1
BRENDA, the Enzyme Database: 7.2.4.1