Entry
Name
(S)-methylmalonyl-CoA decarboxylase (sodium-transporting);
methylmalonyl-coenzyme A decarboxylase (ambiguous);
(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase (incorrect);
(S)-methylmalonyl-CoA carboxy-lyase (ambiguous)
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to decarboxylation
BRITE hierarchy
Sysname
(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming, sodium-transporting)
Reaction(IUBMB)
(S)-methylmalonyl-CoA + Na+[side 1] + H+[side 2] = propanoyl-CoA + CO2 + Na+[side 2]
Substrate
(S)-methylmalonyl-CoA [CPD:
C00683 ];
Na+[side 1];
H+[side 2]
Product
Comment
This bacterial enzyme couples the decarboxylation of (S)-methylmalonyl-CoA to propanoyl-CoA to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis. It is a membrane-associated biotin protein and is strictly dependent on sodium ions for activity.
History
EC 7.2.4.3 created 1972 as EC 4.1.1.41, modified 1983, modified 1986, transferred 2018 to EC 7.2.4.3
Orthology
K01604 methylmalonyl-CoA decarboxylase subunit alpha
Genes
LCJ : NCTC11976_03153(accD5_2)
LWA : SAMEA4504053_2437(accD5)
CNC : CNE_BB2p01110 CNE_BB2p01140(pccB)
COX : E0W60_34740 E0W60_34760
BBH : BN112_0506 BN112_1883
BBM : BN115_1527 BN115_2433
BBX : BBS798_1532 BBS798_2521
BOH : AKI39_04380 AKI39_21480
PUS : CKA81_14100 CKA81_14110
RBM : TEF_14565 TEF_14815 TEF_18490 TEF_19980
RID : RIdsm_01866(accD5_1)
HDH : G5B40_06085 G5B40_11385
DLM : DPPLL_27320 DPPLL_38330
DBK : DGMP_10750 DGMP_10760 DGMP_10900
DAL : Dalk_1740 Dalk_2022 Dalk_2547 Dalk_2548 Dalk_2657 Dalk_2658 Dalk_3780
DALK : DSCA_19380 DSCA_35600
DEK : DSLASN_36400 DSLASN_36900
DAX : FDQ92_13160 FDQ92_13790
SCU : SCE1572_11105 SCE1572_15535
CCRO : CMC5_031720 CMC5_060610
PAUU : E8A73_023895 E8A73_028235
MRM : A7982_12769 A7982_13255
BSED : DN745_00560 DN745_08515
PCAY : FRD00_00520 FRD00_08360
BAZ : BAMTA208_07865(yngE)
BFD : NCTC4823_02585(pccB)
OCN : CUC15_09850 CUC15_15340
GGH : GHH_c16200(yngE) GHH_c22190(yqjD1)
GJF : M493_08290 M493_10910
GEA : GARCT_01610 GARCT_02094
GSR : GS3922_06240 GS3922_08565
GZA : IC807_04075 IC807_06785
HHD : HBHAL_2982 HBHAL_3169
HMN : HM131_08605 HM131_11150
SJE : AAV35_008560 AAV35_011580
RUE : DT065_04520 DT065_18165
SALE : EPH95_04280 EPH95_17735
SCIA : HUG15_14010 HUG15_20920
MDG : K8L98_10420 K8L98_22145
BLEN : NCTC4824_02765(pccB)
SURE : SporoP32a_02415 SporoP32a_14425
VIJ : JNUCC6_09250 JNUCC6_19465
HHJ : NQ487_20625 NQ487_28655
ACOL : K5I23_09665 K5I23_13790
DOR : Desor_1409 Desor_3035 Desor_4205
DAI : Desaci_1895 Desaci_2147
DKU : Desku_0501 Desku_0804 Desku_1365
TFR : BR63_01815 BR63_06370 BR63_17725
FWA : DCMF_05745 DCMF_06385 DCMF_16055 DCMF_26035
DGI : Desgi_1782 Desgi_1959
HCV : FTV88_1283 FTV88_3237
THEF : E1B22_07930 E1B22_10540
THEP : DYI95_004270 DYI95_006915
SAY : TPY_2612(pccB) TPY_3501(mmdA)
SAP : Sulac_1265 Sulac_1413
STHR : BXT84_09635 BXT84_10240
PROM : QO263_04970 QO263_07520
BCRO : NQ527_01070 NQ527_07150
BPRO : PMF13cell1_04192(pccB)
BLAR : LC508_03405 LC508_27435
CSCI : HDCHBGLK_03215(pccB)
ACEL : acsn021_05930 acsn021_26710
KIB : RBB56_06225 RBB56_16430
VGU : HYG85_18760 HYG85_23745
VPY : HZI73_12690 HZI73_17720
GFE : Gferi_08065 Gferi_16890
TTE : TTE1220(AccA) TTE2385(AccA2)
AFT : BBF96_04260 BBF96_05030
KME : H0A61_01397 H0A61_02560
PUF : UFO1_0298 UFO1_2958 UFO1_3052
PFT : JBW_01687 JBW_01697 JBW_01715 JBW_02749
PFAC : PFJ30894_00318 PFJ30894_00910 PFJ30894_00914
ROA : Pd630_LPD07108 Pd630_LPD17025
BSD : BLASA_4391 BLASA_4410
SACG : FDZ84_27830 FDZ84_29775
ABAI : IMCC26256_111118 IMCC26256_111319
BSOL : FSW04_06060 FSW04_12610(cysC) FSW04_23295 FSW04_25060
BALA : DSM104299_00733 DSM104299_01694 DSM104299_05061
PARN : NBH00_19555 NBH00_20335
SBAE : DSM104329_03274(accD5) DSM104329_04558
CPOR : BED41_04295 BED41_10175
ACO : Amico_0267 Amico_0886
ARAM : KAR29_02190 KAR29_07040
BTHO : Btheta7330_01331(accD5_2)
BOA : Bovatus_01768(accD5_2)
BCEL : BcellWH2_04428(accD5_1)
PCAG : NCTC12856_00117(accD5)
PMUC : ING2E5A_1045(pccB_1)
DYS : G7050_03725 G7050_13155
PPN : Palpr_0392 Palpr_0982
PARC : CI960_03930 CI960_07235
PMER : INE87_00080 INE87_01410(pccB_1)
PGOL : K6V26_03870 K6V26_10655
PJO : LK449_04230 LK449_10215
PFAI : NXY11_02590 NXY11_06715
COPR : Cop2CBH44_11960 Cop2CBH44_19930
CFAS : Cfast33896_22870 Cfast33896_24620
OSP : Odosp_1049 Odosp_1778
BUY : D8S85_00825 D8S85_11175 D8S85_18610
BVIR : I6J59_15080 I6J59_17880
BFH : F1611_09090 F1611_11420
POC : NCTC13071_01595(accD5)
PCLR : PC1C4_11300 PC1C4_15830
ALD : GFH31_01355 GFH31_11050
AIT : AI2BBH_03040 AI2BBH_20080
AIU : NQ491_00830 NQ491_09930
RBC : BN938_2753 BN938_2777
TTZ : FHG85_08940 FHG85_10785
BLQ : L21SP5_03509 L21SP5_03931(accD5_3)
BACC : BRDCF_p1208(pccB) BRDCF_p156(yqjD)
DORI : FH5T_07010 FH5T_12410 FH5T_18420
DRC : G0Q07_05895 G0Q07_10665
MCOS : GM418_16115 GM418_28150
ASX : CDL62_02575 CDL62_18135
ALKQ : M9189_05780 M9189_10775
MBAS : ALGA_0603 ALGA_2348
CACI : CLOAM1715 CLOAM1768
LOKI : Lokiarch_39580(accD5)
» show all
Taxonomy
Reference
Authors
Galivan JH, Allen SH.
Title
Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus.
Journal
J Biol Chem 243:1253-61 (1968)
Reference
Authors
Hilpert W, Dimroth P.
Title
Conversion of the chemical energy of methylmalonyl-CoA decarboxylation into a Na+ gradient.
Journal
Reference
Authors
Hoffmann A, Hilpert W, Dimroth P.
Title
The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens.
Journal
Reference
Authors
Huder JB, Dimroth P
Title
Expression of the sodium ion pump methylmalonyl-coenzyme A-decarboxylase from Veillonella parvula and of mutated enzyme specimens in Escherichia coli.
Journal
Sequence
Reference
Authors
Bott M, Pfister K, Burda P, Kalbermatter O, Woehlke G, Dimroth P
Title
Methylmalonyl-CoA decarboxylase from Propionigenium modestum--cloning and sequencing of the structural genes and purification of the enzyme complex.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 7.2.4.3
ExPASy - ENZYME nomenclature database: 7.2.4.3
BRENDA, the Enzyme Database: 7.2.4.3