Entry
Name
ABC-type glutathione transporter;
glutathione transporting ATPase;
glutathione ABC transporter;
gsiACD (gene names)
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type,glutathione-importing)
Reaction(IUBMB)
ATP + H2O + glutathione-[glutathione-binding protein][side 1] = ADP + phosphate + glutathione[side 2] + [glutathione-binding protein][side 1]
Substrate
ATP [CPD:
C00002 ];
H2O [CPD:
C00001 ];
glutathione-[glutathione-binding protein][side 1]
Product
ADP [CPD:
C00008 ];
phosphate [CPD:
C00009 ];
glutathione[side 2];
[glutathione-binding protein][side 1]
Comment
A prokaryotic ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli is a heterotrimeric complex that interacts with an extracytoplasmic substrate binding protein to mediate the uptake of glutathione.
History
EC 7.4.2.10 created 2019
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Sequence
Reference
Authors
Moussatova A, Kandt C, O'Mara ML, Tieleman DP
Title
ATP-binding cassette transporters in Escherichia coli.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.10
ExPASy - ENZYME nomenclature database: 7.4.2.10