KEGG   ENZYME: 7.4.2.13
Entry
EC 7.4.2.13                 Enzyme                                 
Name
ABC-type tyrosine transporter
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
Sysname
ATP phosphohydrolase (ABC-type, L-tyrosine-importing)
Reaction(IUBMB)
ATP + H2O + L-tyrosinyl-[tyrosine-binding protein][side 1] = ADP + phosphate + L-tyrosine[side 2] + [tyrosine-binding protein][side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
L-tyrosinyl-[tyrosine-binding protein][side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
L-tyrosine[side 2];
[tyrosine-binding protein][side 1]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in Clostridioides, interacts with an extracytoplasmic substrate binding lipoprotein and mediates the import of L-tyrosine. L-phenylalanine is also tranported however with lower efficiency.
History
EC 7.4.2.13 created 2019
Reference
1  [PMID:29867812]
  Authors
Steglich M, Hofmann JD, Helmecke J, Sikorski J, Sproer C, Riedel T, Bunk B, Overmann J, Neumann-Schaal M, Nubel U
  Title
Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production.
  Journal
Front Microbiol 9:901 (2018)
DOI:10.3389/fmicb.2018.00901
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.13
IUBMB Enzyme Nomenclature: 7.4.2.13
ExPASy - ENZYME nomenclature database: 7.4.2.13
BRENDA, the Enzyme Database: 7.4.2.13

  All links  
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (4)   
   InterPro (4)   
All databases (6)   

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