KEGG   ENZYME: 7.4.2.14
Entry
EC 7.4.2.14                 Enzyme                                 
Name
ABC-type antigen peptide transporter;
TAP1 (gene name);
TAP2 (gene name)
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
Sysname
ATP phosphohydrolase (ABC-type, antigen peptide-exporting)
Reaction(IUBMB)
ATP + H2O + antigen peptide[side 1] = ADP + phosphate + antigen peptide[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
antigen peptide[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
antigen peptide[side 2]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. This entry describes vertebrate transporters involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with major histocompatibility complex (MHC) class I molecules. The substrates are generated mainly from degradation of cytosolic proteins by the proteasome.
History
EC 7.4.2.14 created 2021
Orthology
K05653  ATP-binding cassette, subfamily B (MDR/TAP), member 2
K05654  ATP-binding cassette, subfamily B (MDR/TAP), member 3
Genes
HSA6890(TAP1) 6891(TAP2)
PTR471978(TAP1) 746399(TAP2)
PPS100969222(TAP1) 100969573(TAP2)
GGO101135419(TAP1) 101135772(TAP2)
PON100444044(TAP1) 100444404(TAP2)
NLE100604022(TAP2) 100605253(TAP1)
HMH116460419(TAP2) 116460421(TAP1)
MCC717726(TAP1) 717742(TAP2)
MCF102142346(TAP1) 102143391(TAP2)
MTHB126952696 126952703
MNI105474418(TAP2) 105474422(TAP1)
CSAB103221692(TAP1) 103221694(TAP2)
CATY105575008(TAP1) 105575012(TAP2)
PANU101014735(TAP1) 101015095
TGE112623507(TAP1) 112623508(TAP2)
MLEU105531116(TAP2) 105531118(TAP1)
RRO104666626(TAP1) 104666628(TAP2)
RBB108512976(TAP1) 108512981(TAP2)
TFN117087011(TAP1) 117087012(TAP2)
PTEH111528120(TAP2) 111528122(TAP1)
CANG105513792(TAP1) 105513794(TAP2)
CJC100406316(TAP2) 100407051(TAP1)
SBQ101050206(TAP1) 101052015(TAP2)
CIMI108300077(TAP1) 108300082(TAP2)
CSYR103271932(TAP2) 103271934(TAP1)
MMUR105886022(TAP1) 105886025(TAP2)
LCAT123631801(TAP1) 123631802(TAP2)
PCOQ105824378(TAP1) 105824379(TAP2)
OGA100940392 100966979(TAP1) 105886923
MMU21354(Tap1) 21355(Tap2)
MCAL110312383(Tap1) 110312451(Tap2)
MPAH110335586(Tap2) 110335738(Tap1)
RNO24811(Tap1) 24812(Tap2)
MCOC116074432(Tap1) 116075049(Tap2)
ANU117724686(Tap1) 117724741(Tap2)
MUN110543126(Tap1) 110543246(Tap2)
CGE100751458(Tap1) 100752033(Tap2)
MAUA101835124(Tap2) 106022611(Tap1)
PROB127224278(Tap1) 127224282(Tap2)
PLEU114686350(Tap1) 114686351(Tap2)
MORG121435237(Tap1) 121435242(Tap2)
MFOT126499436 126499463
AAMP119823090(Tap1) 119823941(Tap2)
NGI103748319(Tap2) 103748644(Tap1)
HGL101703007(Tap2) 101711399(Tap1)
CPOC100716745(Tap1) 100717574(Tap2)
CCAN109686707(Tap1) 109686711(Tap2)
DORD105999854(Tap2) 105999856(Tap1)
DSP122111481(Tap1) 122111482(Tap2)
PLOP125352721(Tap2) 125353513(Tap1)
NCAR124988667 124988990
MMMA107143776(Tap1) 107143777(Tap2)
OCU100349155 100351666
OPI101535473(TAP2) 101535942(TAP1)
TUP102484450(TAP2) 102488648(TAP1)
GVR103608007(TAP2) 103608009(TAP1)
CFA474864(TAP2) 474866(TAP1)
CLUD112641380 112641381(TAP1)
VVP112913862(TAP2) 112913865(TAP1)
VLG121494754(TAP2) 121497333(TAP1)
NPO129512879(TAP2) 129513013(TAP1)
AML100464886(TAP1) 100478040(TAP2)
UMR103665513(TAP1) 103665515(TAP2)
UAH113243780(TAP2) 113243781(TAP1)
UAR123790943(TAP1) 123790946(TAP2)
ELK111152176 111152449
LLV125103272 125103273
MPUF101674199(TAP1)
MNP132017855(TAP2) 132017858(TAP1)
MLK131834271(TAP1) 131834272(TAP2)
NVS122911173(TAP1) 122911181(TAP2)
ORO101369846(TAP2) 101370146(TAP1)
EJU114222136(TAP1) 114222137(TAP2)
ZCA113926807(TAP1) 113927043(TAP2)
MLX118001395(TAP1) 118001396(TAP2)
NSU110575561(TAP2) 110575563(TAP1)
LWW102733853 102749278(TAP1)
FCA101083591(TAP1) 101089770(TAP2)
PYU121029257(TAP2) 121029258(TAP1)
PCOO112862082(TAP2) 112862344(TAP1)
PBG122489371(TAP1) 122489373(TAP2)
LRUF124528921 124528922
PTG102958303(TAP2) 102969103(TAP1)
PPAD109271409(TAP1) 109271411(TAP2)
PUC125938390 125938391
AJU106976125 106976128
HHV120238159(TAP1) 120238160(TAP2)
BTA281586(TAP2) 524959(TAP1) 618733
BOM102269065(TAP1) 102283284(TAP2)
BIU109577139(TAP1) 109577140 109577300
BBUB102391047(TAP2) 102391940(TAP1)
BBIS104994881(TAP2) 104994883(TAP1)
CHX102180638(TAP2) 102181173(TAP1)
OAS101109491(TAP2) 101115580(TAP1)
BTAX128056049(TAP2) 128056161(TAP1)
ODA120869861(TAP1) 120869864(TAP2)
CCAD122429562(TAP1) 122429858(TAP2)
MBEZ129543429(TAP1) 129543658(TAP2)
SSC733649(TAP1) 733650(TAP2)
CFR102506212(TAP1) 102519383(TAP2)
CBAI105064241(TAP1) 105064243(TAP2)
CDK105101403(TAP1) 105101406(TAP2)
VPC102535891(TAP1) 107033346(TAP2)
BACU103011180(TAP1) 103012059(TAP2)
LVE103072764(TAP2) 103084615(TAP1)
OOR101289708(TAP1) 101290371(TAP2)
DLE111178659(TAP2) 111178660(TAP1)
PCAD102995173(TAP1) 102995730(TAP2)
PSIU116762103(TAP1) 116762691(TAP2)
NASI112413821(TAP2) 112413857(TAP1)
ECB100052423(TAP2) 100060845(TAP1)
EAI106834612(TAP1) 106834615(TAP2)
MYB102251714(TAP2) 102252020(TAP1)
MYD102761514(TAP1) 102768370(TAP2)
MMYO118679553(TAP1) 118679593(TAP2)
MLF102421555(TAP1) 102422762(TAP2)
MNA107542666(TAP2) 107542669(TAP1)
PKL118705649(TAP1) 118705652(TAP2)
EFUS114229614(TAP2) 129150467(TAP1)
HAI109378144(TAP2) 109378146(TAP1)
DRO112302216(TAP2) 112302332(TAP1)
SHON118991465(TAP1) 118991466(TAP2)
AJM119049933(TAP1) 119049937(TAP2)
PDIC114494714(TAP2) 114494744(TAP1)
PHAS123816513(TAP1) 123816524(TAP2)
MMF118616803 118621195(TAP1) 118621597(TAP2)
RFQ117020460(TAP1) 117020489(TAP2)
PPAM129067353(TAP2) 129067354(TAP1)
PALE102893312(TAP1) 102894050(TAP2)
PGIG120597635(TAP1) 120597640(TAP2)
PVP105300966(TAP1) 105301037(TAP2)
RAY107511995(TAP1) 107511996(TAP2)
MJV108388306 108388307 108405341(TAP1) 108408874
TOD119251393(TAP2) 119251981 119252147 119252321(TAP1)
SARA101544289(TAP1) 101558640(TAP2)
LAV100672952(TAP1) 104845430(TAP2)
TMU101341807 101342308
ETF101639668(TAP1) 101651090 101651392
DNM101423323(TAP2) 101433457(TAP1)
MDO100026215 100026438 100026571 100026750(TAP1)
GAS123244265 123245211(TAP1) 123246368
SHR100926063(TAP2) 116423203(TAP1)
AFZ127561620 127561621
PCW110199320(TAP2) 110199321 110199346(TAP1) 110199416 110199417
OAA100088116(TAP1) 100529066(TAP2)
GGA427727(TAP1) 427728(TAP2)
PCOC116236740(TAP2) 116236743(TAP1)
MGP100545399 100549494 104913620 104913621
CJO107321558(TAP2) 107321559(TAP1)
TPAI128074264(TAP2) 128074266(TAP1)
LMUT125686235(TAP2) 125686236(TAP1)
NMEL110406669(TAP2) 110406673(TAP1)
APLA101797091 101797680 119718656 119718657
ACYG106029502(TAP1) 106029503(TAP2)
CATA118260282(TAP2) 118260283(TAP1)
AFUL116500214(TAP1) 116500246(TAP2)
TGU115492664
LSR110481230 110481231
SCAN103825036
PMOA120503659 120503661
OTC121334901
PRUF121357157 121357159
GFR102039635
FAB101809296 101809503
OMA130262719 130263319
PHI102108912 102109093
PMAJ107199185 107199186
CCAE111936803
CCW120412065 120412070
CBRC103621494 103621495
ETL114071915 114071916 114072929
SVG106864418
HRT120764784 120764785
EGZ104126843
ACUN113490724
TALA116963340(TAP1) 116963352(TAP2)
AFOR103907923 103908011
ACHC115338299(TAP1) 115338305(TAP2)
HLE104834903(TAP2) 104834904(TAP1)
AGEN126034912 126034916
SHAB115603459(TAP1) 115603463(TAP2)
CPEA104394197(TAP2) 104394208(TAP1)
CVF104292690(TAP2)
RTD128901634(TAP2) 128901640
CUCA104065978
BRHI104498062
AAM106492644(TAP1)
AROW112961738 112961787 112963223
NPD112954976
SCAM104139334(TAP2)
AMJ102563397 102573721
CMY102930546(TAP2) 119567530(TAP1)
CPIC101952783 101953351
CABI116821653 116821654 116821656(TAP1) 116825565
MRV120394809 120394816(TAP1) 120394826(TAP2) 120394827
ACS100554917 100558440 100558977 100559367(tap2) 103282465
ASAO132765336 132765338(TAP2) 132765811 132769673
PVT110070640 110071036(TAP2) 110071192(TAP1)
SUND121922961 121923358 121924256(TAP2)
PBI103056839(TAP2) 103063236(TAP1)
PMUR107296738 107296739(TAP1) 107298995
CTIG120296930 120303324 120317814(TAP2) 120317827(TAP1)
TSR106539698 106544595
PGUT117670028 117670039(TAP1) 117670041
APRI131191777(TAP2) 131191900(TAP1)
PTEX113451016(TAP2) 113451019(TAP1)
NSS113425983(TAP1) 113425984(TAP2)
VKO123023274(TAP1) 123023275(TAP2)
PMUA114591068 114592172 114592235(TAP1) 114592242
PRAF128409344(TAP1) 128409347(TAP2)
ZVI118080216(TAP1) 118081173(TAP2)
HCG128347471
STOW125428578(TAP2) 125428884(TAP1)
XLA100329838(tap1.L) 443560(tap2.L)
XTR100489020(tap2) 100494735(tap1) 108648266 116406716
NPR108788360(TAP1) 108788391(TAP2)
RTEM120914284(TAP2) 120914285(TAP1)
BBUF120977441(TAP1) 120977443(TAP2)
BGAR122919678(TAP2) 122919679(TAP1)
MUO115459432 115459444 115466179 115466180
GSH117349879(TAP1) 117349880(TAP2)
DRE100333043(tap1) 368771(tap2a) 556826(si:dkey-57h18.2)
SRX107711531(tap1) 107715579 107727316
SANH107657063 107668327 107671442 107688213 107694783
SGH107549840 107566640 107574270 107582758 107592117 107592491(tap1)
CCAR109056322(tap1) 109099933 109102778 109112150
CAUA113056162 113059348 113101282 113102784 113115685 113119626 113119915
CGIB127975187 127979732 127979733 128025300 128029986
PTET122333975(tap1) 122335236 122335237 122355730(tap2t)
LROH127160984 127160985 127162476(tap2a) 127174045(tap2t) 127178906(tap1)
OMC131521848(tap1) 131525174(tap2a) 131550522(tap2t)
PPRM120474517(tap2t) 120483323 120483602(tap2a) 120491127(tap1)
RKG130078823(tap1) 130088711(tap2t) 130102332(tap2a)
MAMB125243603(tap1) 125254930(tap2t) 125275693(tap2a) 125275815
CIDE127496810 127500836 127500837 127501509 127523304
MASI127421083 127421092 127422768 127424960 127427046 127453367 127454128
TROS130557752(tap1) 130566601(tap2a) 130569053(tap2t)
TDW130415877(tap2a) 130433405(tap1) 130438590(tap2t)
MANU129420923(tap2t) 129448764(tap1) 129455743(tap2a)
IPU108256340 108258487 108258488 108273873(tap2t)
IFU128600046(tap1) 128601939 128602001 128617045(tap2t)
PHYP113527577 113532964 113537638
SMEO124375525(tap1) 124378196(tap2a) 124388980(tap2t)
TFD113639019(tap2t) 113648838 113649020 113649843(tap1)
TVC132839223 132839425 132840123(tap1) 132864232(tap2t)
AMEX103036712 103042617(tap1)
CMAO118798907(tap1) 118804913(tap2a) 118809341(tap2t)
EEE113578824(tap1) 113579422 113581264
CHAR105888917(tap2a) 105891881(tap1) 105908575(tap2t)
TRU101066072 101070568 101077331
TFS130518424(tap2a) 130525145 130532512(tap1) 130532564
TNGGSTEN00002627G001 GSTEN00022278G001
LCO104928642 104928977 104933388
NCC104944438 104964935 104965249
TBEN117473781(tap2t) 117477847(tap2a) 117500552(tap1)
CGOB115015611 115021787
PGEO117455098(tap2a) 117460585(tap1) 117464709(tap2t)
GACU117543224(tap1) 117547061(tap2t) 117559109(tap2a)
ELY117247010(tap2t) 117263298(tap2a) 117265256(tap1)
EFO125880387(tap2t) 125893418(tap1) 125904719(tap2a)
PLEP121945983(tap1) 121958015(tap2a) 121964095
SLUC116036106(tap1) 116046338 116047052(tap2a) 116061050(tap2t)
ECRA117936512(tap2t) 117945671(tap1) 117956712(tap2a)
ESP116670895 116690885 116702031
PFLV114547941 114557798 114567896 114567980
GAT120810165(tap1) 120819592(tap2t) 120825974 120825975 120825976 120825978 120825979 120826741
PPUG119197942(tap1) 119213335(tap2t) 119218707 119218708 119218719 119219718
AFB129091428(tap2t) 129097299(tap2a) 129109229(tap1)
CLUM117728065(tap1) 117739027(tap2a) 117748736(tap2t)
MSAM119897095(tap1) 119907862(tap2a) 119915562(tap2t)
SCHU122864409(tap2a) 122868208(tap2t) 122881501(tap1)
CUD121513613(tap1) 121524588(tap2a) 121528479(tap2t)
ALAT119005680(tap1) 119010276(tap2t) 119014351(tap2a)
MZE101473113 101483734 101484302(tap1)
ONL100696572 100698679 100701175(tap1)
OAU116311333(tap1) 116317730 116324041 116335631(tap2t)
OLA101162709(tap1) 101165513 101166481(abcb3)
OML112136733(tap1) 112154648(tap2t) 112159448(tap2a)
XMA102217160(tap1) 102218472 102236923
XCO114141733(tap1) 114152292 114156475
XHE116717209(tap1) 116727536 116730541
PRET103460927 103472929 103477852(tap1) 103481747
PFOR103146402 103146690(tap1) 103152415
PLAI106942622 106948877 106960912
PMEI106903295(tap1) 106908352 106915984
GAF122823470(tap2t) 122831242(tap1) 122843197 122844003
PPRL129368353(tap2t) 129370786(tap1) 129375861(tap2a)
CVG107082986 107102461 107104435 107104823
CTUL119777431(tap1) 119782508(tap2t) 119795071(tap2a)
GMU124866324(tap1) 124875088(tap2t) 124879477(tap2a)
NFU107379160 107387476 107394853
KMR108242643(tap2a) 108245991(tap1) 108250652(tap2t)
ALIM106519576 106521986 106523077(tap1)
NWH119409807(tap1) 119424192(tap2t) 119425879(tap2a)
AOCE111567461 111577918 111584583
MCEP125016940(tap1) 125019829(tap2a) 125021964(tap2t)
CSEM103388956 103393838 103398854
POV109642708 109643985 109647062
SSEN122758937(tap2t) 122761149(tap2a) 122774097(tap1)
HHIP117753453(tap2t) 117770930(tap2a) 117776256(tap1)
HSP118100213(tap2t) 118114170(tap1) 118124593(tap2a)
LCF108881897 108888421 108892013(tap2t) 108899590
SDU111220041 111222621(tap1) 111239425
SLAL111655422 111655648(tap1) 111661197
XGL120784568(tap1) 120786276(tap2a) 120794553(tap2t)
HCQ109518554 109521010(tap1) 109527184
SSCV125974814 125978712 125991642
SBIA133495347 133500015(tap2a) 133501431(tap1)
PEE133395408(tap2a) 133401619(tap1) 133417718
PTAO133469131 133470922(tap2a) 133479890(tap1)
BPEC110154207 110171064 110173278
MALB109952510 109962793 109965574(tap1)
BSPL114843532(tap1) 114845343(tap2t) 114866099(tap2a)
SJO128366653(tap1) 128374423(tap2a) 128381631(tap2t)
SASA100136585(tap1) 100136919(tap2a1) 100136924(tap2b) 100195045(abcb3) 106579291
STRU115158879 115173548 115175914 115178246(tap1)
OTW112222999 112223617(tap2t) 112229806 112264786
OMY100135858(tap2t) 110487866(tap1) 110488345 110496230
OGO123997694(tap1) 124012540 124043534 124047585(tap2t)
ONE115106493 115114169 115128386 115131611 115141115(tap1)
OKI109865428 109902065 109903604 109903718 109907523
OKE118364394(tap1) 118366686(tap2t) 118398186 118399308
SALP111954844 111956236 111959198 111965141 111978398 112075849
SNH120022500 120027264 120031373 120046213(tap2t) 120048383
CCLU121543092(tap2t) 121559689 121571581 121586462 123484627 123486448
ELS105006976 105009100 105021865
SFM108926769 108930284 114909099
PKI111834646 111835640 111835644 111838464
AANG118221173(tap2t) 118225073(tap1) 118232953(tap2a)
PSPA121298805 121298806(tap2a) 121298813 121304295(tap1)
ARUT117433949 117433950 117433951 117962717 117964811 117971423
PSEX120539144(tap1)
LCM102358508(TAP2) 102361710(TAP1)
CMK103173390
RTP109939101 109939104
CPLA122541208 122541209
HOC132832854(tap1) 132832855 132832856
LERI129693359 129694074 129694462 129694463
 » show all
Reference
1  [PMID:1946428]
  Authors
Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T.
  Title
Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region.
  Journal
Proc Natl Acad Sci U S A 88:10094-8 (1991)
DOI:10.1073/pnas.88.22.10094
  Sequence
[hsa:6891]
Reference
2  [PMID:8107849]
  Authors
Momburg F, Roelse J, Howard JC, Butcher GW, Hammerling GJ, Neefjes JJ.
  Title
Selectivity of MHC-encoded peptide transporters from human, mouse and rat.
  Journal
Nature 367:648-51 (1994)
DOI:10.1038/367648a0
Reference
3  [PMID:8955196]
  Authors
Nijenhuis M, Hammerling GJ.
  Title
Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site.
  Journal
J Immunol 157:5467-77 (1996)
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.14
IUBMB Enzyme Nomenclature: 7.4.2.14
ExPASy - ENZYME nomenclature database: 7.4.2.14
BRENDA, the Enzyme Database: 7.4.2.14

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