Entry
Name
ABC-type antigen peptide transporter;
TAP1 (gene name);
TAP2 (gene name)
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, antigen peptide-exporting)
Reaction(IUBMB)
ATP + H2O + antigen peptide[side 1] = ADP + phosphate + antigen peptide[side 2]
Substrate
Product
ADP [CPD:
C00008 ];
phosphate [CPD:
C00009 ];
antigen peptide[side 2]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. This entry describes vertebrate transporters involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with major histocompatibility complex (MHC) class I molecules. The substrates are generated mainly from degradation of cytosolic proteins by the proteasome.
History
EC 7.4.2.14 created 2021
Orthology
K05653 ATP-binding cassette, subfamily B (MDR/TAP), member 2
K05654 ATP-binding cassette, subfamily B (MDR/TAP), member 3
Genes
HSA : 6890(TAP1) 6891(TAP2)
PTR : 471978(TAP1) 746399(TAP2)
PPS : 100969222(TAP1) 100969573(TAP2)
GGO : 101135419(TAP1) 101135772(TAP2)
PON : 100444044(TAP1) 100444404(TAP2)
NLE : 100604022(TAP2) 100605253(TAP1)
HMH : 116460419(TAP2) 116460421(TAP1)
MCC : 717726(TAP1) 717742(TAP2)
MCF : 102142346(TAP1) 102143391(TAP2)
MTHB : 126952696 126952703
MNI : 105474418(TAP2) 105474422(TAP1)
CSAB : 103221692(TAP1) 103221694(TAP2)
CATY : 105575008(TAP1) 105575012(TAP2)
PANU : 101014735(TAP1) 101015095
TGE : 112623507(TAP1) 112623508(TAP2)
MLEU : 105531116(TAP2) 105531118(TAP1)
RRO : 104666626(TAP1) 104666628(TAP2)
RBB : 108512976(TAP1) 108512981(TAP2)
TFN : 117087011(TAP1) 117087012(TAP2)
PTEH : 111528120(TAP2) 111528122(TAP1)
CANG : 105513792(TAP1) 105513794(TAP2)
CJC : 100406316(TAP2) 100407051(TAP1)
SBQ : 101050206(TAP1) 101052015(TAP2)
CIMI : 108300077(TAP1) 108300082(TAP2)
CSYR : 103271932(TAP2) 103271934(TAP1)
MMUR : 105886022(TAP1) 105886025(TAP2)
LCAT : 123631801(TAP1) 123631802(TAP2)
PCOQ : 105824378(TAP1) 105824379(TAP2)
OGA : 100940392 100966979(TAP1) 105886923
MMU : 21354(Tap1) 21355(Tap2)
MCAL : 110312383(Tap1) 110312451(Tap2)
MPAH : 110335586(Tap2) 110335738(Tap1)
RNO : 24811(Tap1) 24812(Tap2)
MCOC : 116074432(Tap1) 116075049(Tap2)
ANU : 117724686(Tap1) 117724741(Tap2)
MUN : 110543126(Tap1) 110543246(Tap2)
CGE : 100751458(Tap1) 100752033(Tap2)
MAUA : 101835124(Tap2) 106022611(Tap1)
PROB : 127224278(Tap1) 127224282(Tap2)
PLEU : 114686350(Tap1) 114686351(Tap2)
MORG : 121435237(Tap1) 121435242(Tap2)
MFOT : 126499436 126499463
AAMP : 119823090(Tap1) 119823941(Tap2)
NGI : 103748319(Tap2) 103748644(Tap1)
HGL : 101703007(Tap2) 101711399(Tap1)
CPOC : 100716745(Tap1) 100717574(Tap2)
CCAN : 109686707(Tap1) 109686711(Tap2)
DORD : 105999854(Tap2) 105999856(Tap1)
DSP : 122111481(Tap1) 122111482(Tap2)
PLOP : 125352721(Tap2) 125353513(Tap1)
NCAR : 124988667 124988990
MMMA : 107143776(Tap1) 107143777(Tap2)
OPI : 101535473(TAP2) 101535942(TAP1)
TUP : 102484450(TAP2) 102488648(TAP1)
GVR : 103608007(TAP2) 103608009(TAP1)
CFA : 474864(TAP2) 474866(TAP1)
CLUD : 112641380 112641381(TAP1)
VVP : 112913862(TAP2) 112913865(TAP1)
VLG : 121494754(TAP2) 121497333(TAP1)
NPO : 129512879(TAP2) 129513013(TAP1)
AML : 100464886(TAP1) 100478040(TAP2)
UMR : 103665513(TAP1) 103665515(TAP2)
UAH : 113243780(TAP2) 113243781(TAP1)
UAR : 123790943(TAP1) 123790946(TAP2)
MNP : 132017855(TAP2) 132017858(TAP1)
MLK : 131834271(TAP1) 131834272(TAP2)
NVS : 122911173(TAP1) 122911181(TAP2)
ORO : 101369846(TAP2) 101370146(TAP1)
EJU : 114222136(TAP1) 114222137(TAP2)
ZCA : 113926807(TAP1) 113927043(TAP2)
MLX : 118001395(TAP1) 118001396(TAP2)
NSU : 110575561(TAP2) 110575563(TAP1)
LWW : 102733853 102749278(TAP1)
FCA : 101083591(TAP1) 101089770(TAP2)
PYU : 121029257(TAP2) 121029258(TAP1)
PCOO : 112862082(TAP2) 112862344(TAP1)
PBG : 122489371(TAP1) 122489373(TAP2)
LRUF : 124528921 124528922
PTG : 102958303(TAP2) 102969103(TAP1)
PPAD : 109271409(TAP1) 109271411(TAP2)
HHV : 120238159(TAP1) 120238160(TAP2)
BTA : 281586(TAP2) 524959(TAP1) 618733
BOM : 102269065(TAP1) 102283284(TAP2)
BIU : 109577139(TAP1) 109577140 109577300
BBUB : 102391047(TAP2) 102391940(TAP1)
BBIS : 104994881(TAP2) 104994883(TAP1)
CHX : 102180638(TAP2) 102181173(TAP1)
OAS : 101109491(TAP2) 101115580(TAP1)
BTAX : 128056049(TAP2) 128056161(TAP1)
ODA : 120869861(TAP1) 120869864(TAP2)
CCAD : 122429562(TAP1) 122429858(TAP2)
MBEZ : 129543429(TAP1) 129543658(TAP2)
SSC : 733649(TAP1) 733650(TAP2)
CFR : 102506212(TAP1) 102519383(TAP2)
CBAI : 105064241(TAP1) 105064243(TAP2)
CDK : 105101403(TAP1) 105101406(TAP2)
VPC : 102535891(TAP1) 107033346(TAP2)
BACU : 103011180(TAP1) 103012059(TAP2)
LVE : 103072764(TAP2) 103084615(TAP1)
OOR : 101289708(TAP1) 101290371(TAP2)
DLE : 111178659(TAP2) 111178660(TAP1)
PCAD : 102995173(TAP1) 102995730(TAP2)
PSIU : 116762103(TAP1) 116762691(TAP2)
NASI : 112413821(TAP2) 112413857(TAP1)
ECB : 100052423(TAP2) 100060845(TAP1)
EAI : 106834612(TAP1) 106834615(TAP2)
MYB : 102251714(TAP2) 102252020(TAP1)
MYD : 102761514(TAP1) 102768370(TAP2)
MMYO : 118679553(TAP1) 118679593(TAP2)
MLF : 102421555(TAP1) 102422762(TAP2)
MNA : 107542666(TAP2) 107542669(TAP1)
PKL : 118705649(TAP1) 118705652(TAP2)
EFUS : 114229614(TAP2) 129150467(TAP1)
HAI : 109378144(TAP2) 109378146(TAP1)
DRO : 112302216(TAP2) 112302332(TAP1)
SHON : 118991465(TAP1) 118991466(TAP2)
AJM : 119049933(TAP1) 119049937(TAP2)
PDIC : 114494714(TAP2) 114494744(TAP1)
PHAS : 123816513(TAP1) 123816524(TAP2)
MMF : 118616803 118621195(TAP1) 118621597(TAP2)
RFQ : 117020460(TAP1) 117020489(TAP2)
PPAM : 129067353(TAP2) 129067354(TAP1)
PALE : 102893312(TAP1) 102894050(TAP2)
PGIG : 120597635(TAP1) 120597640(TAP2)
PVP : 105300966(TAP1) 105301037(TAP2)
RAY : 107511995(TAP1) 107511996(TAP2)
MJV : 108388306 108388307 108405341(TAP1) 108408874
TOD : 119251393(TAP2) 119251981 119252147 119252321(TAP1)
SARA : 101544289(TAP1) 101558640(TAP2)
LAV : 100672952(TAP1) 104845430(TAP2)
ETF : 101639668(TAP1) 101651090 101651392
DNM : 101423323(TAP2) 101433457(TAP1)
MDO : 100026215 100026438 100026571 100026750(TAP1)
GAS : 123244265 123245211(TAP1) 123246368
SHR : 100926063(TAP2) 116423203(TAP1)
PCW : 110199320(TAP2) 110199321 110199346(TAP1) 110199416 110199417
OAA : 100088116(TAP1) 100529066(TAP2)
GGA : 427727(TAP1) 427728(TAP2)
PCOC : 116236740(TAP2) 116236743(TAP1)
MGP : 100545399 100549494 104913620 104913621
CJO : 107321558(TAP2) 107321559(TAP1)
TPAI : 128074264(TAP2) 128074266(TAP1)
LMUT : 125686235(TAP2) 125686236(TAP1)
NMEL : 110406669(TAP2) 110406673(TAP1)
APLA : 101797091 101797680 119718656 119718657
ACYG : 106029502(TAP1) 106029503(TAP2)
CATA : 118260282(TAP2) 118260283(TAP1)
AFUL : 116500214(TAP1) 116500246(TAP2)
PMOA : 120503659 120503661
PRUF : 121357157 121357159
PMAJ : 107199185 107199186
CBRC : 103621494 103621495
ETL : 114071915 114071916 114072929
TALA : 116963340(TAP1) 116963352(TAP2)
AFOR : 103907923 103908011
ACHC : 115338299(TAP1) 115338305(TAP2)
HLE : 104834903(TAP2) 104834904(TAP1)
AGEN : 126034912 126034916
SHAB : 115603459(TAP1) 115603463(TAP2)
CPEA : 104394197(TAP2) 104394208(TAP1)
RTD : 128901634(TAP2) 128901640
AROW : 112961738 112961787 112963223
CMY : 102930546(TAP2) 119567530(TAP1)
CPIC : 101952783 101953351
CABI : 116821653 116821654 116821656(TAP1) 116825565
MRV : 120394809 120394816(TAP1) 120394826(TAP2) 120394827
ACS : 100554917 100558440 100558977 100559367(tap2) 103282465
ASAO : 132765336 132765338(TAP2) 132765811 132769673
PVT : 110070640 110071036(TAP2) 110071192(TAP1)
SUND : 121922961 121923358 121924256(TAP2)
PBI : 103056839(TAP2) 103063236(TAP1)
PMUR : 107296738 107296739(TAP1) 107298995
CTIG : 120296930 120303324 120317814(TAP2) 120317827(TAP1)
PGUT : 117670028 117670039(TAP1) 117670041
APRI : 131191777(TAP2) 131191900(TAP1)
PTEX : 113451016(TAP2) 113451019(TAP1)
NSS : 113425983(TAP1) 113425984(TAP2)
VKO : 123023274(TAP1) 123023275(TAP2)
PMUA : 114591068 114592172 114592235(TAP1) 114592242
PRAF : 128409344(TAP1) 128409347(TAP2)
ZVI : 118080216(TAP1) 118081173(TAP2)
STOW : 125428578(TAP2) 125428884(TAP1)
XLA : 100329838(tap1.L) 443560(tap2.L)
XTR : 100489020(tap2) 100494735(tap1) 108648266 116406716
NPR : 108788360(TAP1) 108788391(TAP2)
RTEM : 120914284(TAP2) 120914285(TAP1)
BBUF : 120977441(TAP1) 120977443(TAP2)
BGAR : 122919678(TAP2) 122919679(TAP1)
MUO : 115459432 115459444 115466179 115466180
GSH : 117349879(TAP1) 117349880(TAP2)
DRE : 100333043(tap1) 368771(tap2a) 556826(si:dkey-57h18.2)
SRX : 107711531(tap1) 107715579 107727316
SANH : 107657063 107668327 107671442 107688213 107694783
SGH : 107549840 107566640 107574270 107582758 107592117 107592491(tap1)
CCAR : 109056322(tap1) 109099933 109102778 109112150
CAUA : 113056162 113059348 113101282 113102784 113115685 113119626 113119915
CGIB : 127975187 127979732 127979733 128025300 128029986
PTET : 122333975(tap1) 122335236 122335237 122355730(tap2t)
LROH : 127160984 127160985 127162476(tap2a) 127174045(tap2t) 127178906(tap1)
OMC : 131521848(tap1) 131525174(tap2a) 131550522(tap2t)
PPRM : 120474517(tap2t) 120483323 120483602(tap2a) 120491127(tap1)
RKG : 130078823(tap1) 130088711(tap2t) 130102332(tap2a)
MAMB : 125243603(tap1) 125254930(tap2t) 125275693(tap2a) 125275815
CIDE : 127496810 127500836 127500837 127501509 127523304
MASI : 127421083 127421092 127422768 127424960 127427046 127453367 127454128
TROS : 130557752(tap1) 130566601(tap2a) 130569053(tap2t)
TDW : 130415877(tap2a) 130433405(tap1) 130438590(tap2t)
MANU : 129420923(tap2t) 129448764(tap1) 129455743(tap2a)
IPU : 108256340 108258487 108258488 108273873(tap2t)
IFU : 128600046(tap1) 128601939 128602001 128617045(tap2t)
PHYP : 113527577 113532964 113537638
SMEO : 124375525(tap1) 124378196(tap2a) 124388980(tap2t)
TFD : 113639019(tap2t) 113648838 113649020 113649843(tap1)
TVC : 132839223 132839425 132840123(tap1) 132864232(tap2t)
AMEX : 103036712 103042617(tap1)
CMAO : 118798907(tap1) 118804913(tap2a) 118809341(tap2t)
EEE : 113578824(tap1) 113579422 113581264
CHAR : 105888917(tap2a) 105891881(tap1) 105908575(tap2t)
TRU : 101066072 101070568 101077331
TFS : 130518424(tap2a) 130525145 130532512(tap1) 130532564
TNG : GSTEN00002627G001 GSTEN00022278G001
LCO : 104928642 104928977 104933388
NCC : 104944438 104964935 104965249
TBEN : 117473781(tap2t) 117477847(tap2a) 117500552(tap1)
CGOB : 115015611 115021787
PGEO : 117455098(tap2a) 117460585(tap1) 117464709(tap2t)
GACU : 117543224(tap1) 117547061(tap2t) 117559109(tap2a)
ELY : 117247010(tap2t) 117263298(tap2a) 117265256(tap1)
EFO : 125880387(tap2t) 125893418(tap1) 125904719(tap2a)
PLEP : 121945983(tap1) 121958015(tap2a) 121964095
SLUC : 116036106(tap1) 116046338 116047052(tap2a) 116061050(tap2t)
ECRA : 117936512(tap2t) 117945671(tap1) 117956712(tap2a)
ESP : 116670895 116690885 116702031
PFLV : 114547941 114557798 114567896 114567980
GAT : 120810165(tap1) 120819592(tap2t) 120825974 120825975 120825976 120825978 120825979 120826741
PPUG : 119197942(tap1) 119213335(tap2t) 119218707 119218708 119218719 119219718
AFB : 129091428(tap2t) 129097299(tap2a) 129109229(tap1)
CLUM : 117728065(tap1) 117739027(tap2a) 117748736(tap2t)
MSAM : 119897095(tap1) 119907862(tap2a) 119915562(tap2t)
SCHU : 122864409(tap2a) 122868208(tap2t) 122881501(tap1)
CUD : 121513613(tap1) 121524588(tap2a) 121528479(tap2t)
ALAT : 119005680(tap1) 119010276(tap2t) 119014351(tap2a)
MZE : 101473113 101483734 101484302(tap1)
ONL : 100696572 100698679 100701175(tap1)
OAU : 116311333(tap1) 116317730 116324041 116335631(tap2t)
OLA : 101162709(tap1) 101165513 101166481(abcb3)
OML : 112136733(tap1) 112154648(tap2t) 112159448(tap2a)
XMA : 102217160(tap1) 102218472 102236923
XCO : 114141733(tap1) 114152292 114156475
XHE : 116717209(tap1) 116727536 116730541
PRET : 103460927 103472929 103477852(tap1) 103481747
PFOR : 103146402 103146690(tap1) 103152415
PLAI : 106942622 106948877 106960912
PMEI : 106903295(tap1) 106908352 106915984
GAF : 122823470(tap2t) 122831242(tap1) 122843197 122844003
PPRL : 129368353(tap2t) 129370786(tap1) 129375861(tap2a)
CVG : 107082986 107102461 107104435 107104823
CTUL : 119777431(tap1) 119782508(tap2t) 119795071(tap2a)
GMU : 124866324(tap1) 124875088(tap2t) 124879477(tap2a)
NFU : 107379160 107387476 107394853
KMR : 108242643(tap2a) 108245991(tap1) 108250652(tap2t)
ALIM : 106519576 106521986 106523077(tap1)
NWH : 119409807(tap1) 119424192(tap2t) 119425879(tap2a)
AOCE : 111567461 111577918 111584583
MCEP : 125016940(tap1) 125019829(tap2a) 125021964(tap2t)
CSEM : 103388956 103393838 103398854
POV : 109642708 109643985 109647062
SSEN : 122758937(tap2t) 122761149(tap2a) 122774097(tap1)
HHIP : 117753453(tap2t) 117770930(tap2a) 117776256(tap1)
HSP : 118100213(tap2t) 118114170(tap1) 118124593(tap2a)
LCF : 108881897 108888421 108892013(tap2t) 108899590
SDU : 111220041 111222621(tap1) 111239425
SLAL : 111655422 111655648(tap1) 111661197
XGL : 120784568(tap1) 120786276(tap2a) 120794553(tap2t)
HCQ : 109518554 109521010(tap1) 109527184
SSCV : 125974814 125978712 125991642
SBIA : 133495347 133500015(tap2a) 133501431(tap1)
PEE : 133395408(tap2a) 133401619(tap1) 133417718
PTAO : 133469131 133470922(tap2a) 133479890(tap1)
BPEC : 110154207 110171064 110173278
MALB : 109952510 109962793 109965574(tap1)
BSPL : 114843532(tap1) 114845343(tap2t) 114866099(tap2a)
SJO : 128366653(tap1) 128374423(tap2a) 128381631(tap2t)
SASA : 100136585(tap1) 100136919(tap2a1) 100136924(tap2b) 100195045(abcb3) 106579291
STRU : 115158879 115173548 115175914 115178246(tap1)
OTW : 112222999 112223617(tap2t) 112229806 112264786
OMY : 100135858(tap2t) 110487866(tap1) 110488345 110496230
OGO : 123997694(tap1) 124012540 124043534 124047585(tap2t)
ONE : 115106493 115114169 115128386 115131611 115141115(tap1)
OKI : 109865428 109902065 109903604 109903718 109907523
OKE : 118364394(tap1) 118366686(tap2t) 118398186 118399308
SALP : 111954844 111956236 111959198 111965141 111978398 112075849
SNH : 120022500 120027264 120031373 120046213(tap2t) 120048383
CCLU : 121543092(tap2t) 121559689 121571581 121586462 123484627 123486448
ELS : 105006976 105009100 105021865
SFM : 108926769 108930284 114909099
PKI : 111834646 111835640 111835644 111838464
AANG : 118221173(tap2t) 118225073(tap1) 118232953(tap2a)
PSPA : 121298805 121298806(tap2a) 121298813 121304295(tap1)
ARUT : 117433949 117433950 117433951 117962717 117964811 117971423
LCM : 102358508(TAP2) 102361710(TAP1)
CPLA : 122541208 122541209
HOC : 132832854(tap1) 132832855 132832856
LERI : 129693359 129694074 129694462 129694463
» show all
Taxonomy
Reference
Authors
Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T.
Title
Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region.
Journal
Sequence
Reference
Authors
Momburg F, Roelse J, Howard JC, Butcher GW, Hammerling GJ, Neefjes JJ.
Title
Selectivity of MHC-encoded peptide transporters from human, mouse and rat.
Journal
Reference
Authors
Nijenhuis M, Hammerling GJ.
Title
Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site.
Journal
J Immunol 157:5467-77 (1996)
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.14
ExPASy - ENZYME nomenclature database: 7.4.2.14