KEGG   ENZYME: 7.4.2.3
Entry
EC 7.4.2.3                  Enzyme                                 
Name
mitochondrial protein-transporting ATPase
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
Sysname
ATP phosphohydrolase (mitochondrial protein-importing)
Reaction(IUBMB)
ATP + H2O + mitochondrial-protein[side 1] = ADP + phosphate + mitochondrial-protein[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
mitochondrial-protein[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
mitochondrial-protein[side 2]
Comment
A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex. TIM is the protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.
History
EC 7.4.2.3 created 2000 as EC 3.6.3.51, transferred 2018 to EC 7.4.2.3
Reference
1  [PMID:9171336]
  Authors
Bomer U, Meijer M, Maarse AC, Honlinger A, Dekker PJ, Pfanner N, Rassow J.
  Title
Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane.
  Journal
EMBO J 16:2205-16 (1997)
DOI:10.1093/emboj/16.9.2205
Reference
2  [PMID:7600576]
  Authors
Berthold J, Bauer MF, Schneider HC, Klaus C, Dietmeier K, Neupert W, Brunner M.
  Title
The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system.
  Journal
Cell 81:1085-93 (1995)
DOI:10.1016/S0092-8674(05)80013-3
Reference
3  [PMID:10548718]
  Authors
Voos W, Martin H, Krimmer T, Pfanner N.
  Title
Mechanisms of protein translocation into mitochondria.
  Journal
Biochim Biophys Acta 1422:235-54 (1999)
DOI:10.1016/S0304-4157(99)00007-6
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.3
IUBMB Enzyme Nomenclature: 7.4.2.3
ExPASy - ENZYME nomenclature database: 7.4.2.3
BRENDA, the Enzyme Database: 7.4.2.3

  All links  
Protein sequence (6)   
   RefSeq(pep) (6)   
DNA sequence (14)   
   RefSeq(nuc) (10)   
   GenBank (2)   
   EMBL (2)   
All databases (20)   

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