KEGG   ENZYME: 7.4.2.5
Entry
EC 7.4.2.5                  Enzyme                                 
Name
bacterial ABC-type protein transporter;
PrtDEF (gene names);
hasDEF (gene names);
peptide-transporting ATPase (ambiguous)
Class
Translocases;
Catalysing the translocation of amino acids and peptides;
Linked to the hydrolysis of a nucleoside triphosphate
Sysname
ATP phosphohydrolase (ABC-type, peptide-exporting)
Reaction(IUBMB)
ATP + H2O + protein[side 1] = ADP + phosphate + protein[side 2]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
protein[side 1]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
protein[side 2]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This entry stands for a family of bacterial enzymes that are dedicated to the secretion of one or several closely related proteins belonging to the toxin, protease and lipase families. Examples from Gram-negative bacteria include alpha-hemolysin, cyclolysin, colicin V and siderophores, while examples from Gram-positive bacteria include bacteriocin, subtilin, competence factor and pediocin.
History
EC 7.4.2.5 created 2000 as EC 3.6.3.43, transferred 2018 to EC 7.4.2.5, modified 2019
Reference
1  [PMID:2184029]
  Authors
Letoffe S, Delepelaire P, Wandersman C
  Title
Protease secretion by Erwinia chrysanthemi: the specific secretion functions are  analogous to those of Escherichia coli alpha-haemolysin.
  Journal
EMBO J 9:1375-82 (1990)
DOI:10.1002/j.1460-2075.1990.tb08252.x
Reference
2  [PMID:8085823]
  Authors
Klein C, Entian KD
  Title
Genes involved in self-protection against the lantibiotic subtilin produced by Bacillus subtilis ATCC 6633.
  Journal
Appl Environ Microbiol 60:2793-801 (1994)
DOI:10.1128/AEM.60.8.2793-2801.1994
Reference
3  [PMID:9224868]
  Authors
Binet R, Letoffe S, Ghigo JM, Delepelaire P, Wandersman C.
  Title
Protein secretion by Gram-negative bacterial ABC exporters--a review.
  Journal
Gene 192:7-11 (1997)
DOI:10.1016/S0378-1119(96)00829-3
Other DBs
ExplorEnz - The Enzyme Database: 7.4.2.5
IUBMB Enzyme Nomenclature: 7.4.2.5
ExPASy - ENZYME nomenclature database: 7.4.2.5
BRENDA, the Enzyme Database: 7.4.2.5

  All links  
Protein sequence (523)   
   UniProt (499)   
   SWISS-PROT (13)   
   RefSeq(pep) (11)   
DNA sequence (167)   
   RefSeq(nuc) (22)   
   GenBank (80)   
   EMBL (65)   
Protein domain (10)   
   InterPro (10)   
All databases (700)   

Download RDF
DBGET integrated database retrieval system