KEGG ENZYME: 7.6.2.6

ENZYME: 7.6.2.6

Entry

EC 7.6.2.6                  Enzyme

Name

ABC-type guanine transporter;
guanine-transporting ATPase;
white (gene name);
brown (gene name)

Class

Translocases;
Catalysing the translocation of other compounds;
Linked to the hydrolysis of a nucleoside triphosphate

Sysname

ATP phosphohydrolase (ABC-type, guanine-importing)

Reaction(IUBMB)

ATP + H2O + guanine[side 1] = ADP + phosphate + guanine[side 2]

Substrate

ATP [CPD:C00002];
H2O [CPD:C00001];
guanine[side 1]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
guanine[side 2]

Comment

An ATP-binding cassette (ABC) type transporter found in insects that transports guanine and other purines into pigment granules in the eye, where they are converted to pteridine pigments. The transporter is a hererodimer composed of two different peptides, each containing one membrane-spanning and one cytoplasmic ATP-binding domain. In Drosophila, this transporter is encoded by the white and brown genes.

History

EC 7.6.2.6 created 2000 as EC 3.6.3.37, transferred 2018 to EC 7.6.2.6

Reference

1 [PMID:117796]

Authors

Sullivan DT, Bell LA, Paton DR, Sullivan MC

Title

Purine transport by malpighian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster.

Journal

Biochem Genet 17:565-73 (1979)
DOI:10.1007/bf00498891

Reference

2 [PMID:3149712]

Authors

Dreesen TD, Johnson DH, Henikoff S.

Title

The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes.

Journal

Mol Cell Biol 8:5206-15 (1988)
DOI:10.1128/MCB.8.12.5206

Sequence

[dme:Dmel_CG2759 Dmel_CG17632]

Reference

3 [PMID:2503416]

Authors

Tearle RG, Belote JM, McKeown M, Baker BS, Howells AJ.

Title

Cloning and characterization of the scarlet gene of Drosophila melanogaster.

Journal

Genetics 122:595-606 (1989)

Sequence

[dme:Dmel_CG2759 Dmel_CG4314]

Reference

Authors

Griffiths, J.K. and Sansom, C.E.

Title

The Transporter Factsbook, Academic Press, San Diego, 1998

Reference

5 [PMID:10407069]

Authors

Mackenzie SM, Brooker MR, Gill TR, Cox GB, Howells AJ, Ewart GD

Title

Mutations in the white gene of Drosophila melanogaster affecting ABC transporters that determine eye colouration.

Journal

Biochim Biophys Acta 1419:173-85 (1999)
DOI:10.1016/s0005-2736(99)00064-4

Other DBs

ExplorEnz - The Enzyme Database:

7.6.2.6

IUBMB Enzyme Nomenclature:

7.6.2.6

ExPASy - ENZYME nomenclature database:

7.6.2.6

BRENDA, the Enzyme Database:

7.6.2.6

All links

Protein sequence (7)   
   UniProt (3)   
   SWISS-PROT (3)   
   RefSeq(pep) (1)   
DNA sequence (4)   
   RefSeq(nuc) (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (8)   
   InterPro (8)   
All databases (19)   

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