KEGG   ENZYME: 1.1.1.149
Entry
EC 1.1.1.149                Enzyme                                 
Name
20alpha-hydroxysteroid dehydrogenase;
20alpha-hydroxy steroid dehydrogenase;
20alpha-HSD;
20alpha-HSDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase
Reaction(IUBMB)
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17alpha-hydroxyprogesterone + NAD(P)H + H+ [RN:R03325]
Reaction(KEGG)
R03325;
(other) R02207 R02209 R08958 R08959
Substrate
17alpha,20alpha-dihydroxypregn-4-en-3-one [CPD:C04518];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
17alpha-hydroxyprogesterone [CPD:C01176];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Re-specific with respect to NAD(P)+ (cf. EC 1.1.1.62 17beta-estradiol 17-dehydrogenase).
History
EC 1.1.1.149 created 1972, deleted 1983, reinstated 1986
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
K05295  20alpha-hydroxysteroid dehydrogenase
Genes
HSA: 1645(AKR1C1)
PTR: 100607996
PPS: 100986729
GGO: 101146324 115936027
PON: 100171658(AKR1C1) 100189776
NLE: 100605934
MCC: 711198(AKR1C1) 711360(AKR1C2)
MCF: 101865536(AKR1C1) 102141103
MTHB: 126963006 126963009
MNI: 105490781 105490782
CSAB: 103237807 103237808
CATY: 105587685 105587688
PANU: 101023297
TGE: 112631308 112631309
MLEU: 105532487 105532488 105532490
RRO: 104678925
RBB: 108532991 108532992
TFN: 117083548 117083560 117087703 117087714
CANG: 105521701 105521702
CJC: 100404656(AKR1C1)
SBQ: 101042532
CIMI: 108285104
MMU: 105349(Akr1c18) 77337(Akr1c21)
MCAL: 110308710
MPAH: 110315750 110333790
RNO: 171516(Akr1c3) 291283(Akr1c2) 307092(Akr1c1)
MCOC: 116081947
ANU: 117713814 117713854
MUN: 110539888 110540933 110542801 132649305
CGE: 100768666 100770100 100770388
MAUA: 101839651 101841800 101843587
PROB: 127229804 127229811
PLEU: 114707814 114708002 114708030
MORG: 121432666
MFOT: 126501693
AAMP: 119816162 119817583
NGI: 103725895
HGL: 101716553
CPOC: 100722094 100724342 100724620
CCAN: 109680485
DORD: 105980417
DSP: 122113030
MMMA: 107134068 107150203
OCU: 100348607(PGER1) 100352716
OPI: 101525116 101525279 101526245 118759111
ECB: 100070570
EPZ: 103540778
EAI: 106827244
DNM: 101433871 101435315
GAS: 123247018 123248678
AFZ: 127564339
MUO: 115477556
GSH: 117364122
BBEL: 109473367
HAME: 121859286
 » show all
Reference
1  [PMID:4382486]
  Authors
Shikita M, Inano H, Tamaoki B.
  Title
Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes.
  Journal
Biochemistry 6:1760-4 (1967)
DOI:10.1021/bi00858a026
Reference
2  [PMID:6935192]
  Authors
Strickler RC, Tobias B, Covey DF
  Title
Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site.
  Journal
J Biol Chem 256:316-21 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.149
IUBMB Enzyme Nomenclature: 1.1.1.149
ExPASy - ENZYME nomenclature database: 1.1.1.149
BRENDA, the Enzyme Database: 1.1.1.149
CAS: 9040-08-8

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (13)   
   KEGG COMPOUND (13)   
Chemical reaction (7)   
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   KEGG RCLASS (2)   
Gene (98)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (96)   
Protein sequence (133)   
   UniProt (92)   
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DNA sequence (178)   
   RefSeq(nuc) (39)   
   GenBank (74)   
   EMBL (65)   
3D Structure (4)   
   PDB (4)   
Protein domain (5)   
   InterPro (5)   
All databases (442)   

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