Entry
Name
3alpha-hydroxyglycyrrhetinate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase
Reaction(IUBMB)
3alpha-hydroxyglycyrrhetinate + NADP+ = 3-oxoglycyrrhetinate + NADPH + H+ [RN:
R04099 ]
Reaction(KEGG)
Substrate
3alpha-hydroxyglycyrrhetinate [CPD:
C03930 ];
NADP+ [CPD:
C00006 ]
Product
Comment
Highly specific to 3alpha-hydroxy derivatives of glycyrrhetinate and its analogues. Not identical to EC
1.1.1.50 3alpha-hydroxysteroid dehydrogenase (Si-specific).
History
EC 1.1.1.230 created 1990
Reference
Authors
Akao T, Akao T, Hattori M, Namba T, Kobashi K.
Title
Purification and properties of 3 alpha-hydroxyglycyrrhetinate dehydrogenase of Clostridium innocuum from human intestine.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.230