KEGG   ENZYME: 1.1.1.268
Entry
EC 1.1.1.268                Enzyme                                 
Name
2-(R)-hydroxypropyl-CoM dehydrogenase;
2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase;
2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-{[(2R)-2-hydroxypropyl]sulfanyl}ethane-1-sulfonate:NAD+ oxidoreductase
Reaction(IUBMB)
2-(R)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+ [RN:R05689]
Reaction(KEGG)
R05689
Substrate
2-(R)-hydroxypropyl-CoM [CPD:C11496];
NAD+ [CPD:C00003]
Product
2-oxopropyl-CoM [CPD:C11497];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme is highly specific for (R)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.269, 2-(S)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (S)-enantiomer. This enzyme forms component III of a four-component enzyme system (comprising EC 4.4.1.23 [2-hydroxypropyl-CoM lyase; component I], EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
History
EC 1.1.1.268 created 2001
Orthology
K26078  2-(R)-hydroxypropyl-CoM dehydrogenase
Genes
XAUXaut_4868 Xaut_5049
MEDKQEV83_11405
Reference
1  [PMID:10411892]
  Authors
Allen JR, Clark DD, Krum JG, Ensign SA.
  Title
A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation.
  Journal
Proc Natl Acad Sci U S A 96:8432-7 (1999)
DOI:10.1073/pnas.96.15.8432
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.268
IUBMB Enzyme Nomenclature: 1.1.1.268
ExPASy - ENZYME nomenclature database: 1.1.1.268
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.268
BRENDA, the Enzyme Database: 1.1.1.268
CAS: 244301-33-5

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