KEGG ENZYME: 1.1.1.269

ENZYME: 1.1.1.269

Entry

EC 1.1.1.269                Enzyme

Name

2-(S)-hydroxypropyl-CoM dehydrogenase;
2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase;
2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

2-{[(2S)-2-hydroxypropyl]sulfanyl}ethanesulfonate:NAD+ oxidoreductase

Reaction(IUBMB)

(2S)-2-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+ [RN:R05690]

Reaction(KEGG)

R05690

Substrate

(2S)-2-hydroxypropyl-CoM [CPD:C11498];
NAD+ [CPD:C00003]

Product

2-oxopropyl-CoM [CPD:C11497];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme is highly specific for (2S)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.268, 2-(R)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (R)-enantiomer. This enzyme forms component IV of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.

History

EC 1.1.1.269 created 2001

Orthology

K26079

2-(S)-hydroxypropyl-CoM dehydrogenase

Genes