KEGG ENZYME: 1.1.1.274

ENZYME: 1.1.1.274

Entry

EC 1.1.1.274                Enzyme

Name

2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming);
2,5-diketo-D-gluconate reductase (ambiguous)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

2-dehydro-D-gluconate:NADP+ 2-oxidoreductase (2-dehydro-D-gluconate-forming)

Reaction(IUBMB)

2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+ [RN:R05823]

Reaction(KEGG)

R05823;
(other) R08878

Substrate

2-dehydro-D-gluconate [CPD:C06473];
NADP+ [CPD:C00006]

Product

2,5-didehydro-D-gluconate [CPD:C02780];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme is involved in the catabolism of 2,5-didehydrogluconate. cf. EC 1.1.1.346, 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming).

History

EC 1.1.1.274 created 2002, modified 2013

Reference

Authors

Sonoyama, T., Kageyama, B., Yagi, S. and Mitsushima, K.

Title

Biochemical aspects of 2-keto-L-gulonate accumulation from 2,5-diketo-D-gluconate by Corynebacterium sp. and its mutants.

Journal

Agric Biol Chem 51:3039-3047 (1987)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.274

IUBMB Enzyme Nomenclature:

1.1.1.274

ExPASy - ENZYME nomenclature database:

1.1.1.274

BRENDA, the Enzyme Database:

1.1.1.274

CAS:	95725-95-4

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