KEGG   ENZYME: 1.1.1.299
Entry
EC 1.1.1.299                Enzyme                                 
Name
malate dehydrogenase [NAD(P)+];
MdH II, NAD(P)+-dependent malate dehyrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-malate:NAD(P)+ oxidoreductase
Reaction(IUBMB)
(S)-malate + NAD(P)+ = oxaloacetate + NAD(P)H + H+ [RN:R00342 R00343]
Reaction(KEGG)
R00342 R00343
Substrate
(S)-malate [CPD:C00149];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
oxaloacetate [CPD:C00036];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity [1].
Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).
History
EC 1.1.1.299 created 2009
Reference
1  [PMID:9639601]
  Authors
Thompson H, Tersteegen A, Thauer RK, Hedderich R
  Title
Two malate dehydrogenases in Methanobacterium thermoautotrophicum.
  Journal
Arch Microbiol 170:38-42 (1998)
DOI:10.1007/s002030050612
  Sequence
[mmg:MTBMA_c06400]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.299
IUBMB Enzyme Nomenclature: 1.1.1.299
ExPASy - ENZYME nomenclature database: 1.1.1.299
BRENDA, the Enzyme Database: 1.1.1.299

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Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Protein sequence (15)   
   UniProt (6)   
   SWISS-PROT (6)   
   RefSeq(pep) (3)   
DNA sequence (6)   
   RefSeq(nuc) (4)   
   GenBank (1)   
   EMBL (1)   
Protein domain (7)   
   InterPro (7)   
All databases (38)   

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