Entry
Name
secoisolariciresinol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(-)-secoisolariciresinol:NAD+ oxidoreductase
Reaction(IUBMB)
(-)-secoisolariciresinol + 2 NAD+ = (-)-matairesinol + 2 NADH + 2 H+ [RN:
R10129 ]
Reaction(KEGG)
Substrate
Product
Comment
Isolated from the plants Forsythia intermedia [1] and Podophyllum peltatum [1-3]. An intermediate lactol is detected in vitro.
History
EC 1.1.1.331 created 2012
Pathway
ec00999 Biosynthesis of various plant secondary metabolites
ec01110 Biosynthesis of secondary metabolites
Orthology
K19650 secoisolariciresinol dehydrogenase
Reference
Authors
Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG
Title
Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection.
Journal
Sequence
Reference
Authors
Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C
Title
Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans.
Journal
Sequence
Reference
Authors
Moinuddin SG, Youn B, Bedgar DL, Costa MA, Helms GL, Kang C, Davin LB, Lewis NG
Title
Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.331