KEGG   ENZYME: 1.1.1.39
Entry
EC 1.1.1.39                 Enzyme                                 
Name
malate dehydrogenase (decarboxylating);
'malic' enzyme (ambiguous);
pyruvic-malic carboxylase (ambiguous);
NAD-specific malic enzyme (ambiguous);
NAD-malic enzyme (ambiguous);
malate dehydrogenase (decarboxylating) (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-malate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(S)-malate + NAD+ = pyruvate + CO2 + NADH [RN:R00214]
Reaction(KEGG)
R00214
Substrate
(S)-malate [CPD:C00149];
NAD+ [CPD:C00003]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
There are several forms of malate dehydrogenases that differ in their use of substrates and cofactors. This particular form is found only in the plant kingdom. Unlike EC 1.1.1.38, which catalyses a similar reaction, this enzyme can not bind oxaloacetate, and thus does not decarboxylate exogeneously-added oxaloacetate. cf. EC 1.1.1.37, malate dehydrogenase; EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating); and EC 1.1.1.83, D-malate dehydrogenase (decarboxylating).
History
EC 1.1.1.39 created 1961
Pathway
ec00620  Pyruvate metabolism
ec00710  Carbon fixation in photosynthetic organisms
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00028  malate dehydrogenase (decarboxylating)
Genes
EAF111714933 111716746
LSM121127274
TCF131891736
ATHAT2G13560(NAD-ME1) AT4G00570(NAD-ME2)
ALY9309009 9319868
CRB17882677 17890615
CSAT104705320 104712096 104737720 104748683 104766630 104793732
EUSEUTSA_v10022600mg EUTSA_v10028520mg
BRP103836911 103837635 103858863
BNA106365524 106366363 106388718 106410651 106434956 106438600
BOE106318356 106318857 106328013
RSZ108827160 108828697 108847837
THJ104801455 104817017 104821820
CPAP110814719 110819439
CIT102578068 102613192 127901471
CICCICLE_v10019380mg CICLE_v10024268mg
PVY116135872 116135999
MINC123215684 123217445
TCC18585720 18614193
GRA105779788 105797262 105802672
GHI107911964 107948661 107952931 107954551 107957250 107960344
GAB108460249 108473639 108489905
HSYR120119776 120126166 120135979 120187763 120189144
DZI111287834 111294958 111296010 111304697 111313837
EGR104442071 104444509
GMX100775394 100795823 100799344 100806545 100811081
GSJ114366896 114394531 114405779 114406445 114418473
PVUPHAVU_008G068700g PHAVU_010G041000g PHAVU_010G094700g
VRA106759136 106774063 106774244
VAR108327762 108347668 108347684
VUN114166768 114167293 114183224
VUM124820019 124828028 124828184
CCAJ109797379 109803053 109808017
APRC113848983 113849288 113863262
MTR11420682 11433166 11446923
TPRA123883315 123883456 123888227 123894345
CAM101495744 101498557 101512359
PSAT127075910 127076653 127127125
VVO131616139 131616664 131638323
LJALj3g3v0618140.1(Lj3g3v0618140.1) Lj3g3v0618140.2(Lj3g3v0618140.2)
ADU107463422 107472570 107473149 107485621
AIP107617619 107624845 107634962
AHF112702894 112726786 112730723 112736379 112744045 112775467 112797403
LANG109340825 109356956 109362754
PCIN129290321 129290957
QSAO6P43_017142 O6P43_017582 O6P43_027202
FVE101311315 101311414
RCN112181173 112195955
PPER18784996 18787040
PMUM103331446 103331878
PAVI110759261 110771802
PDUL117617475 117617700 117617857
MDM103406865 103410089 103420647 103426311
MSYL126613974 126623689 126627818 126629316
PXB103929748 103932045 103935555 103935560 103941811 103965503
ZJU107421706 107434740
MNT21389976 21399476 21406650
CSAV115706551 115709889 115709970 115710857
CSV101204181 101212275 116403313 116406292
CMO103483428 103499065
BHJ120067607 120071054
MCHA111016110 111023088
CMAX111473484 111479676 111494177
CMOS111432147 111454410 111464523
CPEP111779018 111791420 111799614
RCU8258537 8266672
JCU105643023 105643271
HBR110656650 110663918 110669466
MESC110614540 110615698 110615778 110617007
POP18105029 7483786 7494056 7496944
PEU105120704 105124900 105133444 105138021
PALZ118034113 118041498 118042322 118057732
JRE108989611 108999352 109008031
CILL122292440 122294846 122309577
CAVE132176656 132186269
QSU111987655 112009249
QLO115958301 115986477
TWL119982702 120003883 120004431
VVI100241371 100261633
VRI117931764 117932479
SLY101246159 101246962
SPEN107008018 107028553
SOT102581802(NAD-ME) 102598070(NAD-ME)
SSTN125842143 125868755
SDUL129886596 129888952
CANN107839152 107848011
LBB132609358 132645613
NTA107775826 107796436 107805341 107806354 107810978
NSY104210631 104224059 104242848
NTO104093154 104093687 104111265
NAU109229152 109237538
INI109155626 109182296 109184308
ITR115995687 116016970 116016997
SIND105172150 105173441
OEU111373253 111410770
EGT105952445 105963770
SSPL121752213 121752219 121784963 121792605 121794541 121795196 121798772
SMIL130999140 131015839
APAN127255177 127261055
HAN110864621 110873556 110931063 110937673
ECAD122581759 122593445 122593711 122599291
LSV111906043 111912885 111916924 111921407
CCAV112519078 112526692 112526699 112529260
DCR108218849 108218977
CSIN114262846 114272458 114285273 114299972 114311305 114319956
RVL131332264 131333297
AEW130773632 130783323 130791683 130795065
BVG104888560 104905215
SOE110777831 110789122
CQI110685325 110685327 110713881 110720454 110721588 110725120
ATRI130809856 130810412 130810413
MOF131165368 131165901
NNU104590669 104596127 104606431
MING122081858 122082471 122086646 122086919
TSS122664431 122664589 122668195 122669090
PSOM113274902 113304446 113322204 113326677 113332529 113332530 113345817
OSA4343294 4349051
DOSAOs07t0496200-01(Os07g0496200) Os10t0503500-01(Os10g0503500)
OBR102709210 102715868
OGL127779981 127786234
BDI100838567 100844092
ATS109740058 109765298
TDC119271014 119335465 119354435 119363581
TAES123044809 123048050 123052611 123123205 123181203 123188587
TUA125509222 125509229 125537282
LPER127302967 127333761
LRD124678239 124681455 124708745
SBI8067080 8077468
ZMA100191942 100501486
SITA101754809 101758088
SVS117836304 117844898
PVIR120644448 120650587 120661403 120685343 120688565 120692869
PHAI112874454 112883548
PDA103704635 103712115
EGU105042873 105053894
MUS103989605 103990429
ZOF121968283 121989327 121998276 122041362 122045865 122050446
DCT110104377 110105405
PEQ110020669 110024664
AOF109825172 109836847
MSIN131231906 131232705
NCOL116265575 116265638
ATR18423085 18429109
SMOSELMODRAFT_110809 SELMODRAFT_176472
PPP112288778
CRECHLRE_06g268750v5
MNGMNEG_12178 MNEG_2849
CSLCOCSUDRAFT_54433
CVRCHLNCDRAFT_136414
OLUOSTLU_26919
OTAOT_ostta12g02650
BPGBathy07g01650
MISMICPUN_55180(NAD-ME)
MPPMICPUCDRAFT_43783(NADP-ME_2)
CCPCHC_T00008878001
NGRNAEGRDRAFT_76270 NAEGRDRAFT_81494
 » show all
Reference
1  [PMID:4399380]
  Authors
Macrae AR
  Title
Isolation and properties of a 'malic' enzyme from cauliflower bud mitochondria.
  Journal
Biochem J 122:495-501 (1971)
DOI:10.1042/bj1220495
Reference
2  [PMID:7294802]
  Authors
Grover SD, Canellas PF, Wedding RT
  Title
Purification of NAD malic enzyme from potato and investigation of some physical and kinetic properties.
  Journal
Arch Biochem Biophys 209:396-407 (1981)
DOI:10.1016/0003-9861(81)90297-6
Reference
3  [PMID:16663114]
  Authors
Wedding RT, Black MK
  Title
Physical and Kinetic Properties and Regulation of the NAD Malic Enzyme Purified from Leaves of Crassula argentea.
  Journal
Plant Physiol 72:1021-8 (1983)
DOI:10.1104/pp.72.4.1021
Reference
4  [PMID:16666776]
  Authors
Wedding RT
  Title
Malic enzymes of higher plants: characteristics, regulation, and physiological function.
  Journal
Plant Physiol 90:367-71 (1989)
DOI:10.1104/pp.90.2.367
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.39
IUBMB Enzyme Nomenclature: 1.1.1.39
ExPASy - ENZYME nomenclature database: 1.1.1.39
BRENDA, the Enzyme Database: 1.1.1.39
CAS: 9028-46-0

DBGET integrated database retrieval system