KEGG ENZYME: 1.1.1.43

ENZYME: 1.1.1.43

Entry

EC 1.1.1.43                 Enzyme

Name

phosphogluconate 2-dehydrogenase;
6-phosphogluconic dehydrogenase;
phosphogluconate dehydrogenase;
gluconate 6-phosphate dehydrogenase;
6-phosphogluconate dehydrogenase (NAD+);
2-keto-6-phosphogluconate reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase

Reaction(IUBMB)

6-phospho-D-gluconate + NAD(P)+ = 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+ [RN:R02032 R02034]

Reaction(KEGG)

R02032 R02034

Substrate

6-phospho-D-gluconate [CPD:C00345];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

6-phospho-2-dehydro-D-gluconate [CPD:C01218];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

History

EC 1.1.1.43 created 1961

Pathway

ec00030

Pentose phosphate pathway

ec00480

Glutathione metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00032

phosphogluconate 2-dehydrogenase

Genes

PAE:

PA2263

PAEV:

N297_2336

PAEI:

N296_2336

PAU:	PA14_35320(kguD)

PAP:	PSPA7_2977

PAG:	PLES_30411

PAF:	PAM18_2777

PNC:	NCGM2_3273(kguD)

PAEB:

NCGM1900_4267(kguD)

PDK:	PADK2_13960

PSG:	G655_13725

PRP:	M062_11835

PAEP:

PA1S_14305

PAER:

PA1R_gp0064

PAEM:

U769_13890

PAEL:

T223_15535

PAES:

SCV20265_3062

PAEU:

BN889_02470

PAEG:

AI22_19550

PAEC:

M802_2333

PAEO:

M801_2335

PCQ:	PcP3B5_34720(ghrB_4)

PPAA:

B7D75_13645

PPU:	PP_3376(ptxD)

PPF:

Pput_2382

PPG:	PputGB1_2568

PPW:	PputW619_2000 PputW619_2571

PPT:

PPS_2854

PPB:	PPUBIRD1_2404

PPI:

YSA_11138

PPX:	T1E_5148(tkrA)

PPUH:

B479_14190

PPUT:

L483_13870

PPUN:

PP4_27660(kguD)

PPUD:

DW66_3112

PMON:

X969_13660

PMOT:

X970_13305

PPJ:	RK21_01808

POR:	APT59_06300

PMOL:

CLJ08_00430

PALD:

LU682_013135

PIX:	RIN61_26190

PMOS:

O165_011465

PFL:	PFL_2717(ghrB1)

PPRC:

PFLCHA0_c27780(ghrB2)

PPRO:

PPC_2764(ghrB1)

PFE:	PSF113_3674(kguD)

PFN:	HZ99_04035

PFO:	Pfl01_2904(yiaE)

PFS:

PFLU_2712

PFC:	PflA506_2981(ghrB1)

PPZ:	H045_10165

PFB:

VO64_0047

PMAN:

OU5_0566

PTV:	AA957_01705

PVR:	PverR02_13675

PAZO:

AYR47_20865

POI:	BOP93_11135

PRX:	HRH33_12390

PMED:

E3Z27_12850

PKR:	AYO71_17590

PMUD:

NCTC8068_02629(ghrB)

PTOL:

I7845_12125

PFW:	PF1751_v1c23760(ghrB)

PFF:	PFLUOLIPICF724840

PFX:	A7318_10960

PLUL:

FOB45_19910

PBA:	PSEBR_a3251

PBC:	CD58_12930

PPUU:

PputUW4_02430

PSK:	U771_18235

PCH:	EY04_16640

PCZ:	PCL1606_27210

PCP:	JM49_14100

PCHP:

C4K32_3427

PFZ:	AV641_12810

PLQ:	AA042_20165

PPV:	NJ69_11480

PSEM:

TO66_17295

PSEC:

CCOS191_2350(ghrB2)

PPSY:

AOC04_09425

PSOS:

POS17_3330(ghrB1)

PFK:	PFAS1_25365

PANR:

A7J50_2583

PPSL:

BJP27_21050

PSIL:

PMA3_15845

PYM:	AK972_2491

PKE:	DLD99_15200

PUM:	HGP31_16590

PGG:	FX982_03690

PPSH:

G5J76_15890

PGY:	AWU82_13105

PEZ:	HWQ56_12570

PBZ:	GN234_05380

PATA:

JWU58_12640

PZE:	HU754_013585

PMOE:

HV782_014295

PSEP:

C4K39_5321

PPII:

QL104_13595

PVW:	HU752_013905

PTRT:

HU722_0013400

PSAM:

HU731_003205

PTZ:	HU718_014240

PSHH:

HU773_014555

PXN:	HU772_014480

PHV:	HU739_003595

PPRG:

HU725_011080

PANH:

HU763_012730

PASG:

KSS96_16120

PMUY:

KSS95_13995

PMAM:

KSS90_11505

PAZE:

KSS91_13355

PALV:

KSS97_12555

PIE:	HU724_015850

PTAE:

NCTC10697_02010(ghrB) NCTC10697_02408(ghrB2)

PGF:	J0G10_16905

PJU:	L1P09_12215

PIZ:	LAB08_R27030

PPEG:

KUA23_12705

PSII:

NF676_14855

PCAS:

LOY40_12055

PFIT:

KJY40_15790

PASI:

LG197_19885

PKM:	PZ739_14625

PNB:	NK667_10235

PTAI:

ICN73_19030

PKK:	QQ992_12430

PKJ:	Q1W70_25130

PHYG:

JTY93_13650

PHOM:

KJF94_12245

PCUC:

PSH97_14565

PPAE:

LDL65_23245

PRHZ:

CRX69_16325

PSJY:

AA098_15195

PSTT:

CH92_21465

PZD:	KQ248_02990

AVN:	Avin_26910(kguD)

AVL:	AvCA_26910(kguD)

AVD:	AvCA6_26910(kguD)

ACX:	Achr_21860(kguD)

CSA:

Csal_0273

CCAG:

SR908_06830

HEL:	HELO_1170(ghrB)

HCS:	FF32_18040

HAK:	KO116_02812

HAM:

HALO3070

HHU:	AR456_01360 AR456_06690

HCO:	LOKO_02347(ghrB)

HALO:

BWR19_17920

HHH:	CLM76_17505

HAF:	C8233_00385

HSV:	HNO53_01735

HPRO:

LMS44_08075 LMS44_10360

HBH:	E4T21_06585 E4T21_18885

HALF:

QEN58_06700 QEN58_08670

HHAO:

QWG60_01160 QWG60_12750

HASO:

B2G49_04675

HASH:

HXW73_06085

HVN:	EI420_12570

HOL:	HORIV_24120

HSR:	HSBAA_22590

HNP:	SR894_06860

HTT:	HZS52_17665 HZS52_19875

HCAM:

I4484_01920

HSX:	HNO51_01825

HTX:	EKK97_02335

HAA:	A5892_14845

CMAI:

BFX80_06870

CAMH:

LCW13_10365

COBE:

CLAM6_20750

COBB:

H2O77_10685

SAJS:

QO259_15660

RPJ:	N234_30545

REH:	H16_B1813(kguD)

CNC:	CNE_2c17540(kguD)

CUH:	BJN34_28480

CBW:	RR42_m1906

COX:	E0W60_19810

CUK:	KB879_14030

PHS:	C2L64_42750

PTER:

C2L65_39915

BUO:	BRPE64_ECDS01190

PUT:

PT7_0392

PUS:	CKA81_08250

POLL:

OEG81_05315

CDN:	BN940_05166

PACR:

FXN63_07470

PARK:

LSG25_09315

POL:

Bpro_1736

PNA:

Pnap_1485

ACK:	C380_16165

ARAD:

KI609_15330

VAP:	Vapar_3413

VPE:	Varpa_2201

VPD:	VAPA_1c35200

VAA:	AX767_01995

VAM:	C4F17_00970

CODO:

LAD35_00445

RTA:	Rta_05240(tkrA)

HYL:	LPB072_01360

HYC:	E5678_20160

MELM:

C7H73_07370

KIA:	G8A07_09020

ATER:

MW290_07725

XYK:	GT347_16870

SECH:

B18_23390

PSTI:

SOO65_16880

PARH:

I5S86_13805

CGOT:

J1899_12015

» show all

Reference

1 [PMID:13894458]

Authors

FRAMPTON EW, WOOD WA.

Title

Carbohydrate oxidation by Pseudomonas fluorescens VI. Conversion of 2-keto-6-phosphogluconate to pyruvate.

Journal

J Biol Chem 236:2571-7 (1961)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.43

IUBMB Enzyme Nomenclature:

1.1.1.43

ExPASy - ENZYME nomenclature database:

1.1.1.43

BRENDA, the Enzyme Database:

1.1.1.43

CAS:

9001-82-5

DBGET integrated database retrieval system