KEGG ENZYME: 1.1.1.64

ENZYME: 1.1.1.64

Entry

EC 1.1.1.64                 Enzyme

Name

testosterone 17beta-dehydrogenase (NADP+);
17-ketoreductase;
NADP-dependent testosterone-17beta-oxidoreductase;
testosterone 17beta-dehydrogenase (NADP)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

17beta-hydroxysteroid:NADP+ 17-oxidoreductase

Reaction(IUBMB)

testosterone + NADP+ = androstenedione + NADPH + H+ [RN:R01838]

Reaction(KEGG)

R01838;
(other) R13219 R13220

Substrate

testosterone [CPD:C00535];
NADP+ [CPD:C00006]

Product

androstenedione [CPD:C00280];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.

History

EC 1.1.1.64 created 1965

Pathway

ec00140

Steroid hormone biosynthesis

ec01100

Metabolic pathways

Orthology

K10207

testosterone 17beta-dehydrogenase (NADP+)

Genes

HSA:	3293(HSD17B3)

PTR:	742116(HSD17B3)

PPS:	100972788(HSD17B3)

GGO:	101137034(HSD17B3)

PON:	100433175(HSD17B3)

NLE:	100584015(HSD17B3)

HMH:	116474221(HSD17B3)

MCC:	709843(HSD17B3)

MCF:	102126699(HSD17B3)

MTHB:

126937930

MNI:	105498922(HSD17B3)

CSAB:

103219820(HSD17B3)

CATY:

105579422(HSD17B3)

PANU:

101019127(HSD17B3)

TGE:	112607782(HSD17B3)

MLEU:

105536600(HSD17B3)

RRO:	104658189(HSD17B3)

RBB:	108529285(HSD17B3)

TFN:	117098279(HSD17B3)

PTEH:

111521711(HSD17B3)

CANG:

105501518(HSD17B3)

CJC:	100414334(HSD17B3)

SBQ:	101030368(HSD17B3)

CIMI:

108317026(HSD17B3)

CSYR:

103259917(HSD17B3)

MMUR:

105883791(HSD17B3)

LCAT:

123646081(HSD17B3)

PCOQ:

105806813(HSD17B3)

OGA:	100959910(HSD17B3)

MMU:	15487(Hsd17b3)

MCAL:

110308323(Hsd17b3)

MPAH:

110334206(Hsd17b3)

RNO:	117182(Hsd17b3)

MCOC:

116081821(Hsd17b3)

ANU:	117714216(Hsd17b3)

MUN:	110555711(Hsd17b3)

CGE:	100767644(Hsd17b3)

MAUA:

101836124(Hsd17b3)

PROB:

127229400(Hsd17b3)

PLEU:

114708428(Hsd17b3)

MORG:

121443355 121453685

MFOT:

126503036

AAMP:

119817874(Hsd17b3)

NGI:	103751616(Hsd17b3)

HGL:	101712135(Hsd17b3)

CPOC:

100728042(Hsd17b3)

CCAN:

109683204(Hsd17b3)

DORD:

105999805(Hsd17b3)

DSP:	122113854(Hsd17b3)

PLOP:

125339851(Hsd17b3)

NCAR:

124965792

MMMA:

107157642(Hsd17b3)

OCU:

100346075

OPI:	101535131(HSD17B3)

TUP:	102477731(HSD17B3)

GVR:	103596807(HSD17B3)

CFA:	100856708(HSD17B3)

CLUD:

112644590(HSD17B3)

VVP:	112908711(HSD17B3)

VLG:	121484594(HSD17B3)

NPO:	129499993(HSD17B3)

AML:	100468038(HSD17B3)

UMR:	103682216(HSD17B3)

UAH:	113269777(HSD17B3)

UAR:	123781398(HSD17B3)

ELK:

111139105

LLV:

125084041

MPUF:

101682480(HSD17B3)

MNP:	132025143(HSD17B3)

MLK:	131812921(HSD17B3)

NVS:	122916955(HSD17B3)

ORO:	101379154(HSD17B3)

EJU:	114223319(HSD17B3)

ZCA:	113934782(HSD17B3)

MLX:	118023370(HSD17B3)

NSU:	110569937(HSD17B3)

LWW:	102747041(HSD17B3)

FCA:	101085324(HSD17B3)

PYU:	121014179(HSD17B3)

PCOO:

112868692(HSD17B3)

PBG:	122475409(HSD17B3)

PVIV:

125149835(HSD17B3)

LRUF:

124525452

PTG:	102972770(HSD17B3)

PPAD:

109251657(HSD17B3)

PUC:

125925381

AJU:

106971466

HHV:	120240840(HSD17B3)

BTA:	616934(HSD17B3)

BOM:	102284785(HSD17B3)

BIU:	109562717(HSD17B3)

BBIS:

104985717(HSD17B3)

CHX:	102188501(HSD17B3)

OAS:	101111157(HSD17B3)

BTAX:

128052768(HSD17B3)

ODA:	120854879(HSD17B3)

CCAD:

122431855(HSD17B3)

MBEZ:

129557383(HSD17B3)

SSC:	100513224(HSD17B3)

CFR:	102514822(HSD17B3)

CBAI:

105078811(HSD17B3)

CDK:	105084686(HSD17B3)

VPC:	102545901(HSD17B3)

BACU:

103006772(HSD17B3)

BMUS:

118897194(HSD17B3)

LVE:	103087691(HSD17B3)

OOR:	101283794(HSD17B3)

DLE:	111166840(HSD17B3)

PCAD:

102990342(HSD17B3)

PSIU:

116755033(HSD17B3)

NASI:

112405476(HSD17B3)

ECB:	100062795(HSD17B3)

EPZ:

103556464

EAI:	106841117(HSD17B3)

MYB:	102256012(HSD17B3)

MYD:	102755784(HSD17B3)

MMYO:

118667642(HSD17B3)

MLF:	102440946(HSD17B3)

PKL:	118732240(HSD17B3)

EFUS:

103297887(HSD17B3)

MNA:	107532302(HSD17B3)

DRO:	112302772(HSD17B3)

SHON:

118993675(HSD17B3)

AJM:	119047823(HSD17B3)

PDIC:

114512517(HSD17B3)

PHAS:

123819445(HSD17B3)

MMF:	118629357(HSD17B3)

PPAM:

129082305(HSD17B3)

HAI:	109371900(HSD17B3)

RFQ:	117032216(HSD17B3)

PALE:

102883847(HSD17B3)

PGIG:

120616894(HSD17B3)

PVP:	105307836(HSD17B3)

RAY:	107500187(HSD17B3)

MJV:	108383363(HSD17B3)

TOD:	119232035(HSD17B3)

SARA:

101551716(HSD17B3)

LAV:	100661701(HSD17B3)

TMU:

101353253

ETF:	101644089(HSD17B3)

DNM:	101425468(HSD17B3)

MDO:	100014335(HSD17B3)

GAS:	123231295(HSD17B3)

SHR:	100935109(HSD17B3)

AFZ:

127561674

PCW:	110197652(HSD17B3)

GGA:	427474(HSD17B3)

PCOC:

116238474(HSD17B3)

CJO:	107306280(HSD17B3)

TPAI:

128089611(HSD17B3)

LMUT:

125687244(HSD17B3)

NMEL:

110390130(HSD17B3)

APLA:

101797428(HSD17B3)

ACYG:

106047350(HSD17B3)

CATA:

118257377(HSD17B3)

AFUL:

116501080(HSD17B3)

TGU:	115491048(HSD17B3)

LSR:	110472744(HSD17B3)

SCAN:

108963255(HSD17B3)

PMOA:

120511983(HSD17B3)

OTC:	121333273(HSD17B3)

PRUF:

121360706(HSD17B3)

GFR:	106631948(HSD17B3)

FAB:	107604273(HSD17B3)

OMA:	130265467(HSD17B3)

PMAJ:

107215831(HSD17B3)

CCAE:

111941803(HSD17B3)

CCW:	109145194(HSD17B3)

CBRC:

108446517(HSD17B3)

ETL:	114055247(HSD17B3)

ZAB:	106629530(HSD17B3)

ACHL:

103801000(HSD17B3)

SVG:	106848868(HSD17B3)

FPG:	101920192(HSD17B3)

FCH:	102057185(HSD17B3)

CLV:	102098536(HSD17B3)

EGZ:	104125984(HSD17B3)

NNI:	104018575(HSD17B3)

PCRI:

104036184(HSD17B3)

PLET:

104623732(HSD17B3)

EHS:	104508316(HSD17B3)

PCAO:

104050977(HSD17B3)

ACUN:

113490002(HSD17B3)

TALA:

116959889(HSD17B3)

PADL:

103920455(HSD17B3)

AFOR:

103893926(HSD17B3)

ACHC:

115336723(HSD17B3)

AGEN:

126035888

GCL:

127027285

CCRI:

104166547(HSD17B3)

CSTI:

104555002(HSD17B3)

CMAC:

104487607(HSD17B3)

FGA:	104079401(HSD17B3)

GSTE:

104257731(HSD17B3)

LDI:	104344387(HSD17B3)

MNB:	103768685(HSD17B3)

OHA:	104331410(HSD17B3)

SHAB:

115600772(HSD17B3)

DPUB:

104298795(HSD17B3)

PGUU:

104471083

CPEA:

104389121(HSD17B3)

AVIT:

104270187(HSD17B3)

CVF:	104287185(HSD17B3)

RTD:	128902313(HSD17B3)

CUCA:

104059932(HSD17B3)

TEO:

104375482

BRHI:

104492849(HSD17B3)

AAM:	106484155(HSD17B3) 106490054

NPD:	112959313(HSD17B3)

TGT:	104576426(HSD17B3)

DNE:	112978782(HSD17B3)

SCAM:

104139668 104141818

ASN:	102387576(HSD17B3)

AMJ:	102576225(HSD17B3)

CPOO:

109323729(HSD17B3)

GGN:	109297533(HSD17B3)

PSS:	102451036(HSD17B3)

CMY:	102936343(HSD17B3)

CCAY:

125636672(HSD17B3)

DCC:	119855611(HSD17B3)

CPIC:

101953074(HSD17B3)

TST:	117879174(HSD17B3)

CABI:

116829331(HSD17B3)

MRV:	120408651(HSD17B3)

ACS:	100561157(hsd17b3)

ASAO:

132766449(HSD17B3)

PVT:	110084176(HSD17B3)

SUND:

121920200(HSD17B3)

PBI:	103062335(HSD17B3)

PMUR:

107299705(HSD17B3)

CTIG:

120300812 120309296(HSD17B3) 120310088

TSR:	106537488(HSD17B3)

PGUT:

117661366(HSD17B3)

APRI:

131190714(HSD17B3)

NSS:	113414617(HSD17B3)

VKO:	123031522(HSD17B3)

PRAF:

128423288(HSD17B3)

ZVI:	118076996(HSD17B3)

HCG:	128344567(HSD17B3)

GJA:	107111659(HSD17B3)

STOW:

125436822(HSD17B3)

EMC:	129334270(HSD17B3)

XLA:	108714716(hsd17b3.L)

XTR:	101730254(hsd17b3)

NPR:	108788141(HSD17B3)

RTEM:

120941808(HSD17B3)

BBUF:

120991496(HSD17B3)

BGAR:

122932050(HSD17B3)

MUO:	115463274(HSD17B3)

GSH:	117352119(HSD17B3)

DRE:	393335(hsd17b3)

SRX:	107711818 107724886

SANH:

107669610 107680221

SGH:	107594530 107602841

CCAR:

109095009 109102469(hsd17b3)

CAUA:

113096377 113107506(hsd17b3)

CGIB:

127962988 128018539

PTET:

122350605(hsd17b3)

LROH:

127170181(hsd17b3)

OMC:	131546071(hsd17b3)

PPRM:

120484683(hsd17b3)

RKG:	130072411(hsd17b3)

MAMB:

125280336(hsd17b3)

CIDE:

127517514

MASI:

127414929 127424342

TROS:

130568195(hsd17b3)

TDW:	130407124(hsd17b3)

MANU:

129414090(hsd17b3)

IPU:

108265426

IFU:	128607838(hsd17b3)

PHYP:

113533063(hsd17b3)

SMEO:

124400526(hsd17b3)

TFD:	113656244(hsd17b3)

TVC:	132853190(hsd17b3)

AMEX:

103031519(hsd17b3)

CMAO:

118813174(hsd17b3)

EEE:

113591248

CHAR:

105894154(hsd17b3)

TRU:	101070933(hsd17b3)

TFS:	130525334(hsd17b3)

TNG:	GSTEN00008855G001

LCO:	104920662(hsd17b3)

NCC:	104963114(hsd17b3)

TBEN:

117473167(hsd17b3)

CGOB:

115013241(hsd17b3)

PGEO:

117452352(hsd17b3)

GACU:

117558652(hsd17b3)

EMAC:

134873930(hsd17b3)

ELY:	117252993(hsd17b3)

EFO:	125889994(hsd17b3)

PLEP:

121944565(hsd17b3)

SLUC:

116054415(hsd17b3)

ECRA:

117944635(hsd17b3)

ESP:	116688929(hsd17b3)

PFLV:

114555989(hsd17b3)

GAT:	120830801(hsd17b3)

PPUG:

119225016(hsd17b3)

AFB:	129101846(hsd17b3)

CLUM:

117735950(hsd17b3)

PSWI:

130196440(hsd17b3)

MSAM:

119892065(hsd17b3)

SCHU:

122876578(hsd17b3)

CUD:	121510306(hsd17b3)

ALAT:

119020264(hsd17b3)

MZE:	101468772(hsd17b3)

ONL:	100700736(hsd17b3)

OAU:	116311165(hsd17b3)

OLA:	100125485(hsd17b3)

OML:	112148263(hsd17b3)

CSAI:

133451091(hsd17b3)

XMA:	102216624(hsd17b3)

XCO:	114154948(hsd17b3)

XHE:	116729729(hsd17b3)

PRET:

103470152(hsd17b3)

PFOR:

103135450(hsd17b3)

PLAI:

106948668(hsd17b3)

PMEI:

106929398

GAF:	122828083(hsd17b3)

PPRL:

129366159(hsd17b3)

CVG:	107098040(hsd17b3)

CTUL:

119781091(hsd17b3)

GMU:	124877181(hsd17b3)

NFU:	107394092(hsd17b3)

KMR:	108244792(hsd17b3)

ALIM:

106513613(hsd17b3)

NWH:	119413044(hsd17b3)

AOCE:

111576668(hsd17b3)

MCEP:

125011683(hsd17b3)

CSEM:

103398902

SSEN:

122769946(hsd17b3)

HHIP:

117767956(hsd17b3)

HSP:	118115624(hsd17b3)

SMAU:

118313405(hsd17b3)

LCF:	108882635(hsd17b3)

SDU:	111236157(hsd17b3)

SLAL:

111644624(hsd17b3)

XGL:	120804874(hsd17b3)

HCQ:

109520684

SSCV:

125993879

SBIA:

133499516(hsd17b3)

PEE:	133399909(hsd17b3)

PTAO:

133475245(hsd17b3)

BPEC:

110167040(hsd17b3)

MALB:

109956598(hsd17b3)

BSPL:

114861636(hsd17b3)

SJO:	128364910(hsd17b3)

SASA:

106580550(DHB3) 106585149(hsd17b3)

STRU:

115164240(hsd17b3) 115200402

OTW:	112248700 112265325

OMY:	110525917(hsd17b3) 110536292

OGO:	124034126(hsd17b3) 124036524

ONE:	115111821 115140278

OKI:	109882607 109895148

OKE:	118371205 118393439

SALP:

111957416 111975060(hsd17b3)

SNH:	120055107 120063373

CCLU:

121557519 121585068(hsd17b3)

ELS:	105014100(hsd17b3)

SFM:	108938393(hsd17b3)

PKI:	111839174(hsd17b3)

AANG:

118237349(hsd17b3)

LOC:	102685301(hsd17b3)

PSPA:

121314969(hsd17b3)

ARUT:

117411678 117419279 117968139

PSEX:

120532653(hsd17b3)

LCM:	102364217(HSD17B3)

CMK:	103182831(hsd17b3)

RTP:	109911861(hsd17b3)

CPLA:

122561611(hsd17b3)

HOC:	132825931(hsd17b3)

LERI:

129695713(hsd17b3)

BBEL:

109481080

» show all

Reference

1 [PMID:13696735]

Authors

ENDAHL GL, KOCHAKIAN CD, HAMM D.

Title

Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver.

Journal

J Biol Chem 235:2792-6 (1960)

Reference

2 [PMID:15436478]

Authors

SWEAT ML, SAMUELS LT, LUMRY R.

Title

Preparation and characterization of the enzyme which converts testosterone to androstenedione.

Journal

J Biol Chem 185:75-84 (1950)

Reference

3 [PMID:13781425]

Authors

VILLEE CA, SPENCER JM.

Title

Some properties of the pyridine nucleotide-specific 17 beta-hydroxy steroid dehydrogenases of guinea pig liver.

Journal

J Biol Chem 235:3615-9 (1960)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.64

IUBMB Enzyme Nomenclature:

1.1.1.64

ExPASy - ENZYME nomenclature database:

1.1.1.64

BRENDA, the Enzyme Database:

1.1.1.64

CAS:

9028-63-1

DBGET integrated database retrieval system