KEGG   ENZYME: 1.1.1.84
Entry
EC 1.1.1.84                 Enzyme                                 
Name
dimethylmalate dehydrogenase;
beta,beta-dimethylmalate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH [RN:R01211]
Reaction(KEGG)
R01211
Substrate
(R)-3,3-dimethylmalate [CPD:C01088];
NAD+ [CPD:C00003]
Product
3-methyl-2-oxobutanoate [CPD:C00141];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
Requires K+ or NH4+ and Mn2+ or Co2+; also acts on (R)-malate.
History
EC 1.1.1.84 created 1972
Pathway
ec00770  Pantothenate and CoA biosynthesis
Reference
1  [PMID:4287371]
  Authors
Magee PT, Snell EE.
  Title
The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to alpha-ketoisovalerate.
  Journal
Biochemistry 5:409-16 (1966)
DOI:10.1021/bi00866a004
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.84
IUBMB Enzyme Nomenclature: 1.1.1.84
ExPASy - ENZYME nomenclature database: 1.1.1.84
BRENDA, the Enzyme Database: 1.1.1.84
CAS: 37250-21-8

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
All databases (10)   

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