| Entry |
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| Name |
homoisocitrate dehydrogenase;
2-hydroxy-3-carboxyadipate dehydrogenase;
3-carboxy-2-hydroxyadipate dehydrogenase;
homoisocitric dehydrogenase;
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating);
3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating);
HICDH
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
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| Reaction(IUBMB) |
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN: R01934]
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| Reaction(KEGG) |
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| Substrate |
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD: C05662];
NAD+ [CPD: C00003]
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| Product |
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| Comment |
Forms part of the lysine biosynthesis pathway in fungi [3].
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| History |
EC 1.1.1.87 created 1972 (EC 1.1.1.155 created 1976, incorporated 2004)
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K05824 | homoisocitrate dehydrogenase |
| K10978 | methanogen homoisocitrate dehydrogenase |
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| Genes |
| NCS: | NCAS_0B06250(NCAS0B06250) |
| NDI: | NDAI_0B03550(NDAI0B03550) |
| TPF: | TPHA_0C03410(TPHA0C03410) |
| TBL: | TBLA_0B05940(TBLA0B05940) |
| TDL: | TDEL_0G02180(TDEL0G02180) |
| KAF: | KAFR_0J01360(KAFR0J01360) |
| KNG: | KNAG_0A05420(KNAG0A05420) |
| PGU: | PGUG_03875 PGUG_03876 |
| CAL: | CAALFM_CR01400WA(LYS12) |
| BBRX: | BRETT_002820(LYS12) |
| NTE: | NEUTE1DRAFT119171(NEUTE1DRAFT_119171) |
| PBEL: | QC761_106340(LYS12) |
| PPSD: | QC762_106340(LYS12) |
| PPSP: | QC763_106340(LYS12) |
| PPSA: | QC764_106340(LYS12) |
| FPOA: | FPOAC1_001498(LYS12) |
| PTKZ: | JDV02_009506(LYS12) |
| ALUC: | AKAW2_60443S(LYS12) |
| CCAC: | CcaHIS019_0111110(LYS12) |
| ABP: | AGABI1DRAFT113649(AGABI1DRAFT_113649) |
| ABV: | AGABI2DRAFT191701(AGABI2DRAFT_191701) |
| SCM: | SCHCO_02623734(SCHCODRAFT_02623734) |
| MEHF: | MmiHf6_03260(hicd_1) |
| MEES: | MmiEs2_06130(hicd_2) |
| MEUZ: | KRP56_01655 KRP56_05915 |
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| Reference |
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| Authors |
Strassman M, Ceci LN. |
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| Title |
Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid. |
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| Journal |
J Biol Chem 240:4357-61 (1965) |
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| Reference |
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| Authors |
Rowley B, Tucci AF |
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| Title |
Homoisocitric dehydrogenase from yeast. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Zabriskie TM, Jackson MD. |
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| Title |
Lysine biosynthesis and metabolism in fungi. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.1.87 |
| ExPASy - ENZYME nomenclature database: | 1.1.1.87 |
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